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PMC:7029759 / 19639-20537 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
419 58-67 Species denotes 2019-nCoV Tax:2697049
438 114-118 Gene denotes ACE2 Gene:59272
439 247-251 Gene denotes ACE2 Gene:59272
440 506-510 Gene denotes ACE2 Gene:59272
441 605-609 Gene denotes scFv Gene:652070
442 641-645 Gene denotes ACE2 Gene:59272
443 828-832 Gene denotes ACE2 Gene:59272
444 889-893 Gene denotes ACE2 Gene:59272
445 791-796 Gene denotes spike Gene:43740568
446 430-435 Gene denotes spike Gene:43740568
447 190-195 Gene denotes spike Gene:43740568
448 168-173 Species denotes human Tax:9606
449 226-237 Species denotes coronavirus Tax:11118
450 457-466 Species denotes 2019-nCoV Tax:2697049
451 704-715 Species denotes coronavirus Tax:11118
452 746-750 Gene denotes ACE2 Gene:59272
453 255-263 Disease denotes infected MESH:D007239
454 364-373 Disease denotes infection MESH:D007239
455 449-453 Disease denotes SARS MESH:D045169

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T735 23-29 CHEBI:52217;CHEBI:52217 denotes agents
T734 58-67 SP_7 denotes 2019-nCoV
T733 103-113 GO:0010467 denotes expressing
T732 114-118 G_3;PG_10;PR:000003622 denotes ACE2
T731 127-131 UBERON:0002048 denotes lung
T730 136-152 UBERON:0001555 denotes gastrointestinal
T729 153-160 UBERON:0000479 denotes tissues
T728 168-173 SP_6;NCBITaxon:9606 denotes human
T727 211-218 GO:0009986 denotes surface
T726 226-237 NCBITaxon:11118 denotes coronavirus
T725 247-251 G_3;PG_10;PR:000003622 denotes ACE2
T724 282-292 GO:0035376 denotes cell entry
T723 410-416 SO:0000417 denotes domain
T722 449-453 SP_10 denotes SARS
T721 457-466 SP_7 denotes 2019-nCoV
T720 506-510 G_3;PG_10;PR:000003622 denotes ACE2
T719 561-569 GO:0042571 denotes antibody
T718 573-579 SO:0000984 denotes single
T717 586-594 GO:0042571 denotes antibody
T716 641-645 G_3;PG_10;PR:000003622 denotes ACE2
T715 704-715 NCBITaxon:11118 denotes coronavirus
T714 746-750 G_3;PG_10;PR:000003622 denotes ACE2
T713 751-764 GO:0005576 denotes extracellular
T712 765-771 SO:0000417 denotes domain
T711 812-818 SO:0000417 denotes domain
T710 828-832 G_3;PG_10;PR:000003622 denotes ACE2
T709 889-893 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T105 83-88 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T106 97-102 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 127-131 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T108 153-160 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T109 168-178 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T110 196-203 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 264-269 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T112 282-286 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T113 436-443 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T114 561-569 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T115 586-594 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T116 797-804 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T8 127-131 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T58 364-373 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 449-453 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T168 83-88 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T169 97-102 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T170 127-131 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T171 127-131 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T172 168-173 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T173 264-269 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T174 282-286 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T175 670-671 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T176 809-811 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T177 894-896 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T75 196-203 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 436-443 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 797-804 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T122 0-9 Sentence denotes Figure 1.
T123 11-89 Sentence denotes Therapeutic agents that could be used to block 2019-nCoV from infecting cells.
T124 90-179 Sentence denotes Target cells expressing ACE2 include lung and gastrointestinal tissues in the human body.
T125 180-293 Sentence denotes The large spike protein on the surface of the coronavirus binds to ACE2 on infected cells, leading to cell entry.
T126 294-374 Sentence denotes Three proposed strategies would block this interaction would abrogate infection.
T127 375-542 Sentence denotes In the first, the receptor-binding domain (RBD) of the spike protein from SARS or 2019-nCoV would be administered, thereby binding ACE2 and saturating available sites.
T128 543-669 Sentence denotes Alternatively, an antibody or single chain antibody fragment (scFv) could be administered against ACE2 to accomplish the same.
T129 670-805 Sentence denotes A third strategy would target the coronavirus virions directly by using the ACE2 extracellular domain as bait to bind to spike protein.
T130 806-898 Sentence denotes An Fc domain fused to ACE2 would facilitate prolonged circulation of the biologic (ACE2-Fc).