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PMC:7029759 / 17743-19638 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
397 50-54 Gene denotes ACE2 Gene:59272
398 195-199 Gene denotes ACE2 Gene:59272
399 445-449 Gene denotes ACE2 Gene:59272
400 692-696 Gene denotes ACE2 Gene:59272
401 739-743 Gene denotes ACE2 Gene:59272
402 129-130 Gene denotes S Gene:43740568
403 413-421 Species denotes patients Tax:9606
404 564-573 Species denotes 2019-nCoV Tax:2697049
405 651-660 Species denotes 2019-nCoV Tax:2697049
406 775-786 Species denotes coronavirus Tax:11118
407 1711-1715 Species denotes mice Tax:10090
408 770-774 Species denotes NL63 Tax:277944
409 124-128 Disease denotes SARS MESH:D045169
410 331-335 Disease denotes SARS MESH:D045169
411 386-390 Disease denotes SARS MESH:D045169
412 487-496 Disease denotes infection MESH:D007239
413 642-646 Disease denotes SARS MESH:D045169
414 761-765 Disease denotes SARS MESH:D045169
415 1528-1532 Disease denotes MERS MESH:D018352
416 1538-1542 Disease denotes MERS MESH:D018352
417 1591-1606 Disease denotes viral infection MESH:D001102

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T393 50-54 G_3;PG_10;PR:000003622 denotes ACE2
T392 102-108 SO:0000417 denotes domain
T391 124-128 SP_10;PG_9 denotes SARS
T390 129-130 PG_9;PG_1 denotes S
T389 131-138 PG_1 denotes protein
T388 173-179 SO:0000417 denotes domain
T387 195-199 G_3;PG_10;PR:000003622 denotes ACE2
T386 249-255 SO:0000417 denotes domain
T385 331-335 SP_10 denotes SARS
T384 386-390 SP_10 denotes SARS
T383 445-449 G_3;PG_10;PR:000003622 denotes ACE2
T382 564-573 SP_7 denotes 2019-nCoV
T381 642-646 SP_10 denotes SARS
T380 651-660 SP_7 denotes 2019-nCoV
T379 676-688 SO:0000409 denotes binding site
T378 692-696 G_3;PG_10;PR:000003622 denotes ACE2
T377 739-743 G_3;PG_10;PR:000003622 denotes ACE2
T376 744-757 SO:0000409 denotes binding sites
T375 761-765 SP_10 denotes SARS
T374 775-786 NCBITaxon:11118 denotes coronavirus
T373 867-877 GO:0042571 denotes antibodies
T372 928-935 UBERON:0000479 denotes tissues
T371 964-969 NCBITaxon:10239;GO:0035376 denotes viral
T370 970-975 GO:0035376 denotes entry
T369 1113-1121 NCBITaxon:2 denotes bacteria
T368 1184-1193 NCBITaxon:2 denotes bacterial
T367 1516-1522 SO:0000417 denotes domain
T366 1528-1532 SP_9 denotes MERS
T365 1538-1542 SP_9 denotes MERS
T364 1591-1596 NCBITaxon:10239;GO:0006260 denotes viral
T363 1657-1663 UBERON:0002405;GO:0006955 denotes immune
T362 1664-1672 GO:0006955 denotes response
T361 1695-1700 NCBITaxon:10239 denotes viral
T360 1701-1707 SO:0000417 denotes domain
T359 1711-1715 NCBITaxon:10088 denotes mice
T358 1822-1828 SO:0000417 denotes domain

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T93 131-138 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 261-272 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T95 339-343 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T96 450-458 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T97 469-474 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T98 928-935 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T99 1054-1061 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 1221-1229 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 1398-1405 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 1505-1515 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T103 1614-1618 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T104 1774-1779 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p4504s27 1862-1871 NegReg denotes eliminate

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T50 124-128 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 331-335 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 386-390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 487-496 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 642-646 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T55 761-765 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T56 1591-1606 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T57 1597-1606 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T150 144-147 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T151 282-285 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T152 339-343 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T153 469-474 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T154 601-602 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 986-988 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T156 1113-1121 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T157 1248-1249 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 1316-1319 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T159 1347-1359 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T160 1430-1432 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T161 1547-1549 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T162 1614-1618 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T163 1743-1745 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T164 1774-1779 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T165 1819-1821 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T166 1872-1874 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T167 1892-1894 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T64 131-138 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T65 261-272 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T66 261-266 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T67 267-272 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T68 450-458 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T69 1054-1061 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 1221-1229 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 1398-1405 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 1505-1515 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T73 1505-1510 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T74 1511-1515 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T10 1591-1606 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T11 1657-1672 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T111 0-55 Sentence denotes There are two known options for agents to bind to ACE2.
T112 56-225 Sentence denotes The first is using the small receptor-binding domain (RBD) from the SARS S protein that has been shown to be the key domain that binds the ACE2 receptor during entry 44.
T113 226-355 Sentence denotes Administration of this domain, 193 amino acids in size, has been shown to effectively block the entry of SARS in cell culture 44.
T114 356-509 Sentence denotes It is well within reason that SARS RBD could be given to patients, thereby binding their ACE2 proteins on target cells, preventing infection ( Figure 1).
T115 510-619 Sentence denotes There is also the potential for the equivalent RBD of 2019-nCoV to be produced and used as a therapy as well.
T116 620-989 Sentence denotes This strategy assumes SARS and 2019-nCoV share the same binding site on ACE2, which is highly likely given the similar ACE2 binding sites of SARS and NL63 coronavirus The small size of the therapy, similar in size in nanobody domains from camelid antibodies, would enhance the perfusion of the biologic into tissues to more effectively bind to viral entry receptors 45.
T117 990-1173 Sentence denotes In regards to the outbreak situation that is ongoing, the small protein facilitates the rapid production of the therapy in bacteria potentially, which would help production yields 19.
T118 1174-1374 Sentence denotes Moreover, bacterial production would allow RBD proteins to be produced in a wide range of production facilities today in China, which already has numerous contract research organization operations 46.
T119 1375-1533 Sentence denotes Alternatively, the RBD protein could be attached to an Fc fragment for extended circulation, which was done for an equivalent 212 amino acid domain from MERS.
T120 1534-1719 Sentence denotes The MERS RBD-Fc fusion demonstrated the ability to block viral infection toward cell receptors, as well as to stimulate an immune response against that specific viral domain in mice 47.
T121 1720-1895 Sentence denotes Of note, since the RBD-Fc fusion would bind to normal cells, one would want to eliminate cytotoxic Fc domain functions through mutations that eliminate Fc receptor binding 48.