PMC:7029759 / 15797-17048 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
350	475-506	Gene	denotes	angiotensin-converting enzyme 2	Gene:59272
351	508-512	Gene	denotes	ACE2	Gene:59272
352	662-666	Gene	denotes	ACE2	Gene:59272
353	967-971	Gene	denotes	ACE2	Gene:59272
354	456-465	Species	denotes	2019-nCoV	Tax:2697049
355	583-599	Species	denotes	SARS coronavirus	Tax:694009
356	641-652	Species	denotes	coronavirus	Tax:11118
357	951-960	Species	denotes	2019-nCoV	Tax:2697049
358	1079-1088	Species	denotes	2019-nCoV	Tax:2697049
359	942-946	Disease	denotes	SARS	MESH:D045169
360	1049-1053	Disease	denotes	SARS	MESH:D045169
361	1103-1107	Disease	denotes	SARS	MESH:D045169
362	1226-1235	Disease	denotes	infection	MESH:D007239
363	1239-1243	Disease	denotes	SARS	MESH:D045169

Id	Subject	Object	Predicate	Lexical cue
T278	98-103	NCBITaxon:10239	denotes	viral
T277	104-116	CHEBI:17089;BV_11;CHEBI:17089	denotes	glycoprotein
T276	202-207	NCBITaxon:10239	denotes	viral
T275	232-244	GO:0009986	denotes	cell surface
T274	267-272	NCBITaxon:10239	denotes	virus
T273	378-383	NCBITaxon:10239	denotes	viral
T272	456-465	SP_7	denotes	2019-nCoV
T271	475-506	PG_10;PR:000003622	denotes	angiotensin-converting enzyme 2
T270	508-512	G_3;PG_10;PR:000003622	denotes	ACE2
T269	583-587	SP_10	denotes	SARS
T268	588-599	NCBITaxon:11118	denotes	coronavirus
T267	628-635	NCBITaxon:10239	denotes	viruses
T266	641-652	NCBITaxon:11118	denotes	coronavirus
T265	662-666	G_3;PG_10;PR:000003622	denotes	ACE2
T264	679-688	PG_1	denotes	S protein
T263	716-725	GO:0061025	denotes	fusion of
T262	730-735	NCBITaxon:10239;GO:0036338	denotes	viral
T261	736-744	GO:0036338	denotes	membrane
T260	749-762	GO:0005886	denotes	cell membrane
T259	793-796	BV_22	denotes	RNA
T258	797-802	BV_22;NCBITaxon:10239	denotes	virus
T257	808-817	GO:0006260	denotes	replicate
T256	822-828	SO:0001026	denotes	genome
T255	891-899	GO:0046903	denotes	secreted
T254	942-946	SP_10	denotes	SARS
T253	951-960	SP_7	denotes	2019-nCoV
T252	967-971	G_3;PG_10;PR:000003622	denotes	ACE2
T251	1049-1053	SP_10	denotes	SARS
T250	1079-1088	SP_7	denotes	2019-nCoV
T249	1103-1107	SP_10	denotes	SARS
T248	1239-1243	SP_10	denotes	SARS

Id	Subject	Object	Predicate	Lexical cue	fma_id
T76	104-116	Body_part	denotes	glycoprotein	http://purl.org/sig/ont/fma/fma62925
T77	217-224	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T78	232-244	Body_part	denotes	cell surface	http://purl.org/sig/ont/fma/fma67653
T79	232-236	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T80	396-400	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T81	532-536	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T82	681-688	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T83	749-762	Body_part	denotes	cell membrane	http://purl.org/sig/ont/fma/fma63841
T84	749-753	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T85	793-796	Body_part	denotes	RNA	http://purl.org/sig/ont/fma/fma67095
T86	822-828	Body_part	denotes	genome	http://purl.org/sig/ont/fma/fma84116
T87	840-844	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T88	916-921	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T43	583-587	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T44	942-946	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T45	1049-1053	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T46	1103-1107	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T47	1226-1235	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T48	1239-1243	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091

Id	Subject	Object	Predicate	Lexical cue
T131	145-146	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T132	232-236	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T133	267-272	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T134	396-400	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T135	410-411	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T136	517-518	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T137	532-536	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T138	543-545	http://purl.obolibrary.org/obo/CLO_0053794	denotes	41
T139	628-635	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	viruses
T140	736-744	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membrane
T141	749-753	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T142	754-762	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membrane
T143	797-802	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T144	840-844	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T145	916-921	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T57	104-116	Chemical	denotes	glycoprotein	http://purl.obolibrary.org/obo/CHEBI_17089
T58	217-224	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T59	475-486	Chemical	denotes	angiotensin	http://purl.obolibrary.org/obo/CHEBI_48433
T60	681-688	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080

Id	Subject	Object	Predicate	Lexical cue
T98	0-126	Sentence	denotes	However, there is another strategy to pursue in this scenario that does not rely on targeting the viral glycoprotein directly.
T99	127-310	Sentence	denotes	In this strategy, a neutralizing effect could be obtained by targeting the viral receptor protein on the cell surface, thereby blocking the virus from binding to it and gaining entry.
T100	311-409	Sentence	denotes	Fortunately, scientists have already uncovered the identity of the viral receptor in cell culture.
T101	410-618	Sentence	denotes	A recent pre-print publication found that the 2019-nCoV uses the angiotensin-converting enzyme 2 (ACE2) as a receptor for cell entry 41, which is the same receptor that the SARS coronavirus uses for entry 42.
T102	619-774	Sentence	denotes	For both viruses, the coronavirus binds to ACE2 through its S protein on the virion, where after fusion of the viral membrane and cell membrane will occur.
T103	775-922	Sentence	denotes	Subsequently, the RNA virus will replicate its genome inside the cell, and ultimately make new virions that will be secreted to infect other cells.
T104	923-1089	Sentence	denotes	The coincidence of SARS and 2019-nCoV using ACE2 receptor opens up the possibility of using the extensive research studied on SARS entry and applying it to 2019-nCoV.
T105	1090-1251	Sentence	denotes	Based on the SARS literature, several potential blocking strategies could be considered, which were shown to be effective in preventing infection in SARS models.