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PMC:7029759 / 153-2179 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
26 1188-1219 Gene denotes angiotensin-converting enzyme 2 Gene:59272
27 1221-1225 Gene denotes ACE2 Gene:59272
28 1266-1270 Gene denotes ACE2 Gene:59272
29 1436-1440 Gene denotes ACE2 Gene:59272
30 1484-1488 Gene denotes ACE2 Gene:59272
31 1648-1652 Gene denotes ACE2 Gene:59272
32 2-19 Species denotes novel coronavirus Tax:2697049
33 21-30 Species denotes 2019-nCoV Tax:2697049
34 410-419 Species denotes 2019-nCoV Tax:2697049
35 489-497 Species denotes patients Tax:9606
36 576-585 Species denotes 2019-nCoV Tax:2697049
37 589-597 Species denotes patients Tax:9606
38 1125-1134 Species denotes 2019-nCoV Tax:2697049
39 1801-1809 Species denotes patients Tax:9606
40 1923-1931 Species denotes patients Tax:9606
41 81-92 Species denotes respiratory Tax:12814
42 822-837 Chemical denotes oligonucleotide MESH:D009841
43 194-202 Disease denotes infected MESH:D007239
44 298-317 Disease denotes 2019-nCoV infection MESH:C000657245
45 425-434 Disease denotes infection MESH:D007239
46 521-526 Disease denotes death MESH:D003643
47 1516-1525 Disease denotes infection MESH:D007239
48 1553-1579 Disease denotes acute respiratory distress MESH:D012128
49 1914-1922 Disease denotes infected MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T31 8-19 NCBITaxon:11118 denotes coronavirus
T30 21-30 SP_7 denotes 2019-nCoV
T29 93-98 NCBITaxon:10239 denotes viral
T28 203-214 NCBITaxon:1 denotes individuals
T27 298-307 SP_7 denotes 2019-nCoV
T26 410-419 SP_7 denotes 2019-nCoV
T25 521-526 GO:0016265 denotes death
T24 576-585 SP_7 denotes 2019-nCoV
T23 744-748 CHEBI:23888;CHEBI:23888 denotes drug
T22 797-805 GO:0042571 denotes antibody
T21 861-866 NCBITaxon:10239 denotes viral
T20 871-877 SO:0001026 denotes genome
T19 1056-1061 NCBITaxon:10239 denotes virus
T18 1125-1134 SP_7 denotes 2019-nCoV
T17 1172-1177 NCBITaxon:10239 denotes viral
T16 1188-1219 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T15 1221-1225 G_3;PG_10;PR:000003622 denotes ACE2
T14 1240-1254 GO:0019814 denotes immunoglobulin
T11 1301-1309 GO:0042571 denotes antibody
T10 1343-1348 NCBITaxon:10239 denotes viral
T9 1391-1404 UBERON:0002405 denotes immune system
T8 1436-1440 G_3;PG_10;PR:000003622 denotes ACE2
T7 1484-1488 G_3;PG_10;PR:000003622 denotes ACE2
T6 1503-1508 UBERON:0000170 denotes lungs
T5 1559-1570 UBERON:0001004 denotes respiratory
T4 1648-1652 G_3;PG_10;PR:000003622 denotes ACE2
T3 1735-1742 BV_20 denotes protein
T2 1743-1753 BV_20;GO:0010467 denotes expression
T1 1781-1785 CHEBI:23888;CHEBI:23888 denotes drug
T13 1258-1264 SO:0000417 denotes domain
T12 1266-1270 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 797-805 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T2 867-870 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T3 871-877 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T4 1240-1254 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T5 1301-1309 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T6 1391-1404 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T7 1503-1508 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T8 1656-1663 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 1735-1742 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1391-1404 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 298-317 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T2 308-317 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 425-434 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 1516-1525 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T3 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T4 69-70 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 153-160 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T6 266-267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 993-994 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1056-1061 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 1102-1103 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1147-1148 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1255-1257 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T12 1271-1273 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T13 1286-1287 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1391-1404 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T15 1441-1443 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T16 1503-1508 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T17 1599-1600 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 1653-1655 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T19 1891-1892 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 1939-1940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 744-748 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T2 822-837 Chemical denotes oligonucleotide http://purl.obolibrary.org/obo/CHEBI_7754
T3 1188-1199 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 1656-1663 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5 1735-1742 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 1781-1785 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T7 1841-1847 Chemical denotes formal http://purl.obolibrary.org/obo/CHEBI_48341

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T5 0-132 Sentence denotes A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population.
T6 133-215 Sentence denotes Current efforts are focused on containment and quarantine of infected individuals.
T7 216-318 Sentence denotes Ultimately, the outbreak could be controlled with a protective vaccine to prevent 2019-nCoV infection.
T8 319-527 Sentence denotes While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death.
T9 528-717 Sentence denotes Herein, I review the potential options to treat 2019-nCoV in patients, with an emphasis on the necessity for speed and timeliness in developing new and effective therapies in this outbreak.
T10 718-936 Sentence denotes I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches.
T11 937-1085 Sentence denotes Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future.
T12 1086-1431 Sentence denotes The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity.
T13 1432-1627 Sentence denotes The ACE2-Fc therapy would also supplement decreased ACE2 levels in the lungs during infection, thereby directly treating acute respiratory distress pathophysiology as a third mechanism of action.
T14 1628-1885 Sentence denotes The sequence of the ACE2-Fc protein is provided to investigators, allowing its possible use in recombinant protein expression systems to start producing drug today to treat patients under compassionate use, while formal clinical trials are later undertaken.
T15 1886-2026 Sentence denotes Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1559-1579 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098