PMC:7029759 / 1239-1584 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"26","span":{"begin":102,"end":133},"obj":"Gene"},{"id":"27","span":{"begin":135,"end":139},"obj":"Gene"},{"id":"28","span":{"begin":180,"end":184},"obj":"Gene"},{"id":"38","span":{"begin":39,"end":48},"obj":"Species"}],"attributes":[{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:59272"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:59272"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:59272"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T18","span":{"begin":39,"end":48},"obj":"SP_7"},{"id":"T17","span":{"begin":86,"end":91},"obj":"NCBITaxon:10239"},{"id":"T16","span":{"begin":102,"end":133},"obj":"PG_10;PR:000003622"},{"id":"T15","span":{"begin":135,"end":139},"obj":"G_3;PG_10;PR:000003622"},{"id":"T14","span":{"begin":154,"end":168},"obj":"GO:0019814"},{"id":"T11","span":{"begin":215,"end":223},"obj":"GO:0042571"},{"id":"T10","span":{"begin":257,"end":262},"obj":"NCBITaxon:10239"},{"id":"T9","span":{"begin":305,"end":318},"obj":"UBERON:0002405"},{"id":"T13","span":{"begin":172,"end":178},"obj":"SO:0000417"},{"id":"T12","span":{"begin":180,"end":184},"obj":"G_3;PG_10;PR:000003622"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":154,"end":168},"obj":"Body_part"},{"id":"T5","span":{"begin":215,"end":223},"obj":"Body_part"},{"id":"T6","span":{"begin":305,"end":318},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":305,"end":318},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T9","span":{"begin":16,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":61,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":169,"end":171},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T12","span":{"begin":185,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T13","span":{"begin":200,"end":201},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":305,"end":318},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":102,"end":113},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T12","span":{"begin":0,"end":345},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain (ACE2-Fc), providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity."}