PMC:7025480 / 37550-38851 JSONTXT

{"project":"TEST0","denotations":[{"id":"32117250-123-129-3633061","span":{"begin":123,"end":125},"obj":"[\"17387214\"]"},{"id":"32117250-127-133-3633062","span":{"begin":127,"end":129},"obj":"[\"26857769\"]"},{"id":"32117250-89-95-3633063","span":{"begin":221,"end":223},"obj":"[\"19965953\"]"},{"id":"32117250-93-99-3633064","span":{"begin":225,"end":227},"obj":"[\"6504106\"]"},{"id":"32117250-97-103-3633065","span":{"begin":229,"end":231},"obj":"[\"26595727\"]"},{"id":"32117250-101-107-3633066","span":{"begin":233,"end":235},"obj":"[\"24637203\"]"},{"id":"32117250-152-158-3633067","span":{"begin":584,"end":586},"obj":"[\"1549817\"]"},{"id":"32117250-156-162-3633068","span":{"begin":588,"end":590},"obj":"[\"24167159\"]"},{"id":"32117250-237-243-3633069","span":{"begin":694,"end":696},"obj":"[\"26729873\"]"},{"id":"32117250-206-212-3633070","span":{"begin":974,"end":976},"obj":"[\"26861017\"]"},{"id":"32117250-93-99-3633071","span":{"begin":1072,"end":1074},"obj":"[\"21998395\"]"},{"id":"32117250-97-103-3633072","span":{"begin":1076,"end":1078},"obj":"[\"21998394\"]"},{"id":"32117250-154-160-3633073","span":{"begin":1133,"end":1135},"obj":"[\"21833331\"]"},{"id":"32117250-158-164-3633074","span":{"begin":1137,"end":1139},"obj":"[\"24439896\"]"},{"id":"32117250-155-161-3633075","span":{"begin":1297,"end":1299},"obj":"[\"22072772\"]"}],"text":"Pseudomonas aeruginosa infections have been associated with a worse outcome in CF and with an increased exacerbation rate (10, 57). Interestingly pulmonary exacerbation in CF has been associated with respiratory viruses (13, 14, 20, 55), which might indicate an interplay between respiratory viruses and P. aeruginosa infections. This might be more important at early stages of CF when P. aeruginosa infections are not yet chronic. In addition, respiratory virus infections have been associated with the conversion of intermittent infections to chronic infections with P. aeruginosa (22, 23) caused by increased biofilm growth of P. aeruginosa due to increased iron concentrations in the lung (58). Thereby P. aeruginosa would directly benefit from a viral infection. Bacterial superinfections of respiratory viral infections are much better described in the literature than viral superinfections and involvement of interferon λ in this scenario has been suggested as well (59). However, several studies show that gut bacteria are able to foster enteric virus infections (60, 61) even though the underlying mechanisms are different (62, 63). In addition, AprA or another LasR dependent protease might directly modify RSV or hRV virions thereby increasing their infectivity, similar to reoviruses (64)."}

{"project":"2_test","denotations":[{"id":"32117250-17387214-35176933","span":{"begin":123,"end":125},"obj":"17387214"},{"id":"32117250-26857769-35176934","span":{"begin":127,"end":129},"obj":"26857769"},{"id":"32117250-19965953-35176935","span":{"begin":221,"end":223},"obj":"19965953"},{"id":"32117250-6504106-35176936","span":{"begin":225,"end":227},"obj":"6504106"},{"id":"32117250-26595727-35176937","span":{"begin":229,"end":231},"obj":"26595727"},{"id":"32117250-24637203-35176938","span":{"begin":233,"end":235},"obj":"24637203"},{"id":"32117250-1549817-35176939","span":{"begin":584,"end":586},"obj":"1549817"},{"id":"32117250-24167159-35176940","span":{"begin":588,"end":590},"obj":"24167159"},{"id":"32117250-26729873-35176941","span":{"begin":694,"end":696},"obj":"26729873"},{"id":"32117250-26861017-35176942","span":{"begin":974,"end":976},"obj":"26861017"},{"id":"32117250-21998395-35176943","span":{"begin":1072,"end":1074},"obj":"21998395"},{"id":"32117250-21998394-35176944","span":{"begin":1076,"end":1078},"obj":"21998394"},{"id":"32117250-21833331-35176945","span":{"begin":1133,"end":1135},"obj":"21833331"},{"id":"32117250-24439896-35176946","span":{"begin":1137,"end":1139},"obj":"24439896"},{"id":"32117250-22072772-35176947","span":{"begin":1297,"end":1299},"obj":"22072772"}],"text":"Pseudomonas aeruginosa infections have been associated with a worse outcome in CF and with an increased exacerbation rate (10, 57). Interestingly pulmonary exacerbation in CF has been associated with respiratory viruses (13, 14, 20, 55), which might indicate an interplay between respiratory viruses and P. aeruginosa infections. This might be more important at early stages of CF when P. aeruginosa infections are not yet chronic. In addition, respiratory virus infections have been associated with the conversion of intermittent infections to chronic infections with P. aeruginosa (22, 23) caused by increased biofilm growth of P. aeruginosa due to increased iron concentrations in the lung (58). Thereby P. aeruginosa would directly benefit from a viral infection. Bacterial superinfections of respiratory viral infections are much better described in the literature than viral superinfections and involvement of interferon λ in this scenario has been suggested as well (59). However, several studies show that gut bacteria are able to foster enteric virus infections (60, 61) even though the underlying mechanisms are different (62, 63). In addition, AprA or another LasR dependent protease might directly modify RSV or hRV virions thereby increasing their infectivity, similar to reoviruses (64)."}

{"project":"MyTest","denotations":[{"id":"32117250-17387214-35176933","span":{"begin":123,"end":125},"obj":"17387214"},{"id":"32117250-26857769-35176934","span":{"begin":127,"end":129},"obj":"26857769"},{"id":"32117250-19965953-35176935","span":{"begin":221,"end":223},"obj":"19965953"},{"id":"32117250-6504106-35176936","span":{"begin":225,"end":227},"obj":"6504106"},{"id":"32117250-26595727-35176937","span":{"begin":229,"end":231},"obj":"26595727"},{"id":"32117250-24637203-35176938","span":{"begin":233,"end":235},"obj":"24637203"},{"id":"32117250-1549817-35176939","span":{"begin":584,"end":586},"obj":"1549817"},{"id":"32117250-24167159-35176940","span":{"begin":588,"end":590},"obj":"24167159"},{"id":"32117250-26729873-35176941","span":{"begin":694,"end":696},"obj":"26729873"},{"id":"32117250-26861017-35176942","span":{"begin":974,"end":976},"obj":"26861017"},{"id":"32117250-21998395-35176943","span":{"begin":1072,"end":1074},"obj":"21998395"},{"id":"32117250-21998394-35176944","span":{"begin":1076,"end":1078},"obj":"21998394"},{"id":"32117250-21833331-35176945","span":{"begin":1133,"end":1135},"obj":"21833331"},{"id":"32117250-24439896-35176946","span":{"begin":1137,"end":1139},"obj":"24439896"},{"id":"32117250-22072772-35176947","span":{"begin":1297,"end":1299},"obj":"22072772"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Pseudomonas aeruginosa infections have been associated with a worse outcome in CF and with an increased exacerbation rate (10, 57). Interestingly pulmonary exacerbation in CF has been associated with respiratory viruses (13, 14, 20, 55), which might indicate an interplay between respiratory viruses and P. aeruginosa infections. This might be more important at early stages of CF when P. aeruginosa infections are not yet chronic. In addition, respiratory virus infections have been associated with the conversion of intermittent infections to chronic infections with P. aeruginosa (22, 23) caused by increased biofilm growth of P. aeruginosa due to increased iron concentrations in the lung (58). Thereby P. aeruginosa would directly benefit from a viral infection. Bacterial superinfections of respiratory viral infections are much better described in the literature than viral superinfections and involvement of interferon λ in this scenario has been suggested as well (59). However, several studies show that gut bacteria are able to foster enteric virus infections (60, 61) even though the underlying mechanisms are different (62, 63). In addition, AprA or another LasR dependent protease might directly modify RSV or hRV virions thereby increasing their infectivity, similar to reoviruses (64)."}