PMC:7025480 / 2409-3753 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7025480","sourcedb":"PMC","sourceid":"7025480","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7025480","text":"Especially chronic airway infections with P. aeruginosa have been correlated with an accelerated loss of lung function (3, 4). P. aeruginosa infections typically start as intermittent infection with environmental strains that initially are sensitive to antibiotic eradication. However, over time P. aeruginosa undergoes adaptive mutations including gain of antibiotic resistance, loss of virulence factors, e.g., proteases or pyocyanin production, and increased alginate synthesis. This favors the establishment of chronic infection and resistance to antibiotic treatment that results in failure of eradication (5). Several secreted proteases of P. aeruginosa have been described modulating the inflammatory response of the host. As such, LasB, a protease under the control of the quorum sensing receptor LasR, has been demonstrated to degrade IL-6 and IL-8. This helps P. aeruginosa to establish an infection since it blocks the recruitment of leukocytes (6). Also other LasR regulated proteases (7, 8), like LasA or AprA, have been demonstrated to degrade cytokines and might act in the same way as LasB (9). Interestingly, as soon as P. aeruginosa infection has been established, LasR often acquires loss of function mutations during the transition of intermittent to chronic infections and thereby further boosts pulmonary inflammation (6).","tracks":[{"project":"TEST0","denotations":[{"id":"32117250-120-125-3633001","span":{"begin":120,"end":121},"obj":"[\"11343046\"]"},{"id":"32117250-123-128-3633002","span":{"begin":123,"end":124},"obj":"[\"12112774\"]"},{"id":"32117250-130-135-3633003","span":{"begin":612,"end":613},"obj":"[\"11106223\"]"},{"id":"32117250-98-103-3633004","span":{"begin":957,"end":958},"obj":"[\"26457326\"]"},{"id":"32117250-40-45-3633005","span":{"begin":1001,"end":1002},"obj":"[\"22154939\"]"},{"id":"32117250-146-151-3633006","span":{"begin":1107,"end":1108},"obj":"[\"22131330\"]"},{"id":"32117250-230-235-3633007","span":{"begin":1341,"end":1342},"obj":"[\"26457326\"]"}],"attributes":[{"subj":"32117250-120-125-3633001","pred":"source","obj":"TEST0"},{"subj":"32117250-123-128-3633002","pred":"source","obj":"TEST0"},{"subj":"32117250-130-135-3633003","pred":"source","obj":"TEST0"},{"subj":"32117250-98-103-3633004","pred":"source","obj":"TEST0"},{"subj":"32117250-40-45-3633005","pred":"source","obj":"TEST0"},{"subj":"32117250-146-151-3633006","pred":"source","obj":"TEST0"},{"subj":"32117250-230-235-3633007","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"32117250-11343046-35176873","span":{"begin":120,"end":121},"obj":"11343046"},{"id":"32117250-12112774-35176874","span":{"begin":123,"end":124},"obj":"12112774"},{"id":"32117250-11106223-35176875","span":{"begin":612,"end":613},"obj":"11106223"},{"id":"32117250-26457326-35176876","span":{"begin":957,"end":958},"obj":"26457326"},{"id":"32117250-22154939-35176877","span":{"begin":1001,"end":1002},"obj":"22154939"},{"id":"32117250-22131330-35176878","span":{"begin":1107,"end":1108},"obj":"22131330"},{"id":"32117250-26457326-35176879","span":{"begin":1341,"end":1342},"obj":"26457326"}],"attributes":[{"subj":"32117250-11343046-35176873","pred":"source","obj":"2_test"},{"subj":"32117250-12112774-35176874","pred":"source","obj":"2_test"},{"subj":"32117250-11106223-35176875","pred":"source","obj":"2_test"},{"subj":"32117250-26457326-35176876","pred":"source","obj":"2_test"},{"subj":"32117250-22154939-35176877","pred":"source","obj":"2_test"},{"subj":"32117250-22131330-35176878","pred":"source","obj":"2_test"},{"subj":"32117250-26457326-35176879","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"32117250-11343046-35176873","span":{"begin":120,"end":121},"obj":"11343046"},{"id":"32117250-12112774-35176874","span":{"begin":123,"end":124},"obj":"12112774"},{"id":"32117250-11106223-35176875","span":{"begin":612,"end":613},"obj":"11106223"},{"id":"32117250-26457326-35176876","span":{"begin":957,"end":958},"obj":"26457326"},{"id":"32117250-22154939-35176877","span":{"begin":1001,"end":1002},"obj":"22154939"},{"id":"32117250-22131330-35176878","span":{"begin":1107,"end":1108},"obj":"22131330"},{"id":"32117250-26457326-35176879","span":{"begin":1341,"end":1342},"obj":"26457326"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32117250-11343046-35176873","pred":"source","obj":"MyTest"},{"subj":"32117250-12112774-35176874","pred":"source","obj":"MyTest"},{"subj":"32117250-11106223-35176875","pred":"source","obj":"MyTest"},{"subj":"32117250-26457326-35176876","pred":"source","obj":"MyTest"},{"subj":"32117250-22154939-35176877","pred":"source","obj":"MyTest"},{"subj":"32117250-22131330-35176878","pred":"source","obj":"MyTest"},{"subj":"32117250-26457326-35176879","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ecd993","default":true},{"id":"2_test","color":"#bf93ec"},{"id":"MyTest","color":"#93eca5"}]}]}}