PMC:7020535 / 3164-4290 JSONTXT

{"project":"0_colil","denotations":[{"id":"31802721-28687722-4170","span":{"begin":719,"end":720},"obj":"28687722"}],"text":"The question of whether epilepsy is a static or dynamic process has been a subject of debate since Gowers proclaimed that “seizures beget seizures.” Is epilepsy a progressive disease? That was part of the title for an Epilepsia review in 2000.1 That paper concluded that the answer is complicated and depends in part on how we define disease progression. Fast forward to 2017 when a meta-analysis examining whether progressive atrophy is demonstrated in intractable temporal lobe epilepsy (TLE) stated as a preamble that “It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.”2 The conclusion of this meta-analysis was that while the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have not employed robust enough designs to directly demonstrate it. The authors exhorted investigators to employ longitudinal multicohort studies to unequivocally differentiate atrophy due to normal aging from epilepsy disease progression."}

{"project":"TEST0","denotations":[{"id":"31802721-230-235-4170","span":{"begin":719,"end":720},"obj":"[\"28687722\"]"}],"text":"The question of whether epilepsy is a static or dynamic process has been a subject of debate since Gowers proclaimed that “seizures beget seizures.” Is epilepsy a progressive disease? That was part of the title for an Epilepsia review in 2000.1 That paper concluded that the answer is complicated and depends in part on how we define disease progression. Fast forward to 2017 when a meta-analysis examining whether progressive atrophy is demonstrated in intractable temporal lobe epilepsy (TLE) stated as a preamble that “It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.”2 The conclusion of this meta-analysis was that while the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have not employed robust enough designs to directly demonstrate it. The authors exhorted investigators to employ longitudinal multicohort studies to unequivocally differentiate atrophy due to normal aging from epilepsy disease progression."}

{"project":"2_test","denotations":[{"id":"31802721-28687722-28641019","span":{"begin":719,"end":720},"obj":"28687722"}],"text":"The question of whether epilepsy is a static or dynamic process has been a subject of debate since Gowers proclaimed that “seizures beget seizures.” Is epilepsy a progressive disease? That was part of the title for an Epilepsia review in 2000.1 That paper concluded that the answer is complicated and depends in part on how we define disease progression. Fast forward to 2017 when a meta-analysis examining whether progressive atrophy is demonstrated in intractable temporal lobe epilepsy (TLE) stated as a preamble that “It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.”2 The conclusion of this meta-analysis was that while the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have not employed robust enough designs to directly demonstrate it. The authors exhorted investigators to employ longitudinal multicohort studies to unequivocally differentiate atrophy due to normal aging from epilepsy disease progression."}

{"project":"MyTest","denotations":[{"id":"31802721-28687722-28641019","span":{"begin":719,"end":721},"obj":"28687722"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The question of whether epilepsy is a static or dynamic process has been a subject of debate since Gowers proclaimed that “seizures beget seizures.” Is epilepsy a progressive disease? That was part of the title for an Epilepsia review in 2000.1 That paper concluded that the answer is complicated and depends in part on how we define disease progression. Fast forward to 2017 when a meta-analysis examining whether progressive atrophy is demonstrated in intractable temporal lobe epilepsy (TLE) stated as a preamble that “It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.”2 The conclusion of this meta-analysis was that while the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have not employed robust enough designs to directly demonstrate it. The authors exhorted investigators to employ longitudinal multicohort studies to unequivocally differentiate atrophy due to normal aging from epilepsy disease progression."}

{"project":"testtesttest","denotations":[{"id":"T11","span":{"begin":56,"end":63},"obj":"Body_part"},{"id":"T12","span":{"begin":466,"end":479},"obj":"Body_part"},{"id":"T13","span":{"begin":564,"end":577},"obj":"Body_part"},{"id":"T14","span":{"begin":623,"end":628},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0004529"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0001871"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001871"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A15","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"}],"text":"The question of whether epilepsy is a static or dynamic process has been a subject of debate since Gowers proclaimed that “seizures beget seizures.” Is epilepsy a progressive disease? That was part of the title for an Epilepsia review in 2000.1 That paper concluded that the answer is complicated and depends in part on how we define disease progression. Fast forward to 2017 when a meta-analysis examining whether progressive atrophy is demonstrated in intractable temporal lobe epilepsy (TLE) stated as a preamble that “It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.”2 The conclusion of this meta-analysis was that while the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have not employed robust enough designs to directly demonstrate it. The authors exhorted investigators to employ longitudinal multicohort studies to unequivocally differentiate atrophy due to normal aging from epilepsy disease progression."}