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PMC:7019868 / 23734-25848 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
456 80-85 Species denotes swine Tax:9823
457 200-205 Species denotes swine Tax:9823
458 239-263 Species denotes porcine deltacoronavirus Tax:1586324
459 282-323 Species denotes swine acute diarrhea syndrome coronavirus Tax:2032731
460 1064-1068 Species denotes PEDV Tax:28295
461 1241-1245 Species denotes PEDV Tax:28295
462 2081-2085 Species denotes PEDV Tax:28295
463 0-7 Species denotes Porcine Tax:1586324
464 265-270 Species denotes PDCoV Tax:1586324
465 325-333 Species denotes SADS-CoV Tax:2032731
466 1279-1286 Chemical denotes iPEDVPT
467 1302-1309 Chemical denotes iPEDVPT
468 1348-1355 Chemical denotes iPEDVPT
469 1367-1374 Chemical denotes iPEDVPT
470 1871-1878 Chemical denotes iPEDVPT
471 2019-2026 Chemical denotes iPEDVPT
472 8-25 Disease denotes epidemic diarrhea MESH:D003967
473 1598-1606 Disease denotes diarrhea MESH:D003967

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T117 1136-1140 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T118 1400-1404 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T119 1495-1499 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T120 1668-1672 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T121 1753-1761 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T122 1779-1783 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T26 17-25 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T27 288-302 Disease denotes acute diarrhea http://purl.obolibrary.org/obo/MONDO_0000257
T28 294-302 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T29 325-329 Disease denotes SADS http://purl.obolibrary.org/obo/MONDO_0000694|http://purl.obolibrary.org/obo/MONDO_0054866
T31 1211-1221 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T32 1598-1606 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T257 48-49 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 144-149 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T259 364-369 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T260 488-489 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T261 515-516 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 632-633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 716-722 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T264 739-744 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T265 1136-1140 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T266 1182-1184 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T267 1339-1346 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T268 1400-1404 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T269 1436-1441 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T270 1495-1499 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T271 1544-1549 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T272 1668-1672 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T273 1731-1736 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T274 1779-1783 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T275 2031-2036 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T276 2095-2096 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T52 679-691 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T53 1461-1470 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T54 1461-1470 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T55 1481-1489 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T56 1582-1596 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T57 1910-1919 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T58 1910-1919 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T59 2068-2077 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T60 2068-2077 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T167 0-158 Sentence denotes Porcine epidemic diarrhea (PED) to date remains a colossal burden to the global swine industries owing to the lack of successful vaccine in the field [12,13].
T168 159-465 Sentence denotes Moreover, other emerging and re-emerging swine enteric coronaviruses, including porcine deltacoronavirus (PDCoV) [24], and swine acute diarrhea syndrome coronavirus (SADS-CoV) [25], further complicate the field condition by affecting diagnostic accuracy and increasing the risk of viral recombination [26].
T169 466-600 Sentence denotes Hence, there is still a pressing need to develop a safe and effective vaccine, particularly the LAV, to mount this disastrous disease.
T170 601-758 Sentence denotes The reverse genetics system is a powerful and widely used tool to study viral pathogenesis and novel LAV design by active modification of genes of interests.
T171 759-942 Sentence denotes Previous studies using reverse genetics on other coronaviruses have identified many virulent/attenuating determinants that might be shared among different genus of coronaviruses [12].
T172 943-1080 Sentence denotes Nevertheless, direct evidences of attenuation due to harboring those mutated determinant(s) in pigs are still limited in PEDV [16,23,27].
T173 1081-1405 Sentence denotes In the present study, to investigate the role of the S gene in the attenuation process of the PEDVPT 52 strain, we generated four infectious cDNA clones of G2b PEDV, including the parental virulent iPEDVPT-P5, attenuated iPEDVPT-P96, as well as two chimeric viruses (iPEDVPT-P5-96S and iPEDVPT-P96-5S) with exchanged S gene.
T174 1406-1637 Sentence denotes We found that the iPEDVPT-P96 virus fully regained the virulence after the exchange of S gene derived from the highly virulent iPEDVPT-P5 virus, showing comparable patterns of viral shedding, diarrhea and histopathological changes.
T175 1638-1857 Sentence denotes Our data confirmed that the S gene is the primary attenuating determinant of the iPEDVPT-P96 virus and the genetic backbone other than the S gene involving the attenuation of the iPEDVPT-P96 might be of less importance.
T176 1858-2037 Sentence denotes However, the iPEDVPT-P5-96S still exhibited partial virulence resulting in severer villous attenuation and higher mortality rate compared to those caused by the iPEDVPT-P96 virus.
T177 2038-2114 Sentence denotes This result supports that the virulence of PEDV might be a multigenic event.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T19 17-25 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T20 294-302 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T21 1598-1606 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014

2_test

Id Subject Object Predicate Lexical cue
31905842-31689903-144353229 151-153 31689903 denotes 12
31905842-27545066-144353230 154-156 27545066 denotes 13
31905842-29569144-144353231 273-275 29569144 denotes 24
31905842-29618817-144353232 336-338 29618817 denotes 25
31905842-30654269-144353233 461-463 30654269 denotes 26
31905842-31689903-144353234 938-940 31689903 denotes 12
31905842-28490591-144353235 1073-1075 28490591 denotes 23