PMC:7019005 / 27171-27912 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7019005","sourcedb":"PMC","sourceid":"7019005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7019005","text":"In isolated cardiac myocytes, sarcomeric contractions were decreased in septic cells at lower stimulation rates (1, 0.5 Hz). Application of MSC did not exert any significant effect on sarcomeric contraction regardless whether in control (non-septic; not shown) or septic cardiac myocytes (Figure 7A). Kinetic parameters of sarcomeric contractions (e.g., time to 50% of peak contraction, time to 50% relaxation) were not affected by sepsis nor by application of MSCs (not shown). Mitochondrial respiration was suppressed in septic hearts and this reduction was mainly due to inhibition of Complex II and IV. Application of MSCs, either in control (not shown) or septic animals, did not affect cardiac mitochondrial respiration (Figures 7B,C).","tracks":[]}