PMC:7003341 / 51566-52552 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T214","span":{"begin":610,"end":614},"obj":"Body_part"},{"id":"T215","span":{"begin":834,"end":838},"obj":"Body_part"},{"id":"T216","span":{"begin":925,"end":932},"obj":"Body_part"}],"attributes":[{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A215","pred":"fma_id","subj":"T215","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma12278"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T135","span":{"begin":610,"end":614},"obj":"Body_part"},{"id":"T136","span":{"begin":834,"end":838},"obj":"Body_part"}],"attributes":[{"id":"A135","pred":"uberon_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A136","pred":"uberon_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T147","span":{"begin":67,"end":71},"obj":"Disease"},{"id":"T148","span":{"begin":441,"end":445},"obj":"Disease"},{"id":"T149","span":{"begin":753,"end":757},"obj":"Disease"}],"attributes":[{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T366","span":{"begin":535,"end":541},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T367","span":{"begin":610,"end":614},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T368","span":{"begin":610,"end":614},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T369","span":{"begin":834,"end":838},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T370","span":{"begin":834,"end":838},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T371","span":{"begin":899,"end":901},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T372","span":{"begin":903,"end":905},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T373","span":{"begin":941,"end":944},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T65482","span":{"begin":40,"end":55},"obj":"Chemical"},{"id":"T34121","span":{"begin":117,"end":132},"obj":"Chemical"},{"id":"T39356","span":{"begin":321,"end":339},"obj":"Chemical"},{"id":"T57763","span":{"begin":555,"end":570},"obj":"Chemical"},{"id":"T37255","span":{"begin":665,"end":680},"obj":"Chemical"},{"id":"T90243","span":{"begin":925,"end":932},"obj":"Chemical"}],"attributes":[{"id":"A69244","pred":"chebi_id","subj":"T65482","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A78929","pred":"chebi_id","subj":"T34121","obj":"http://purl.obolibrary.org/obo/CHEBI_24261"},{"id":"A47224","pred":"chebi_id","subj":"T39356","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"},{"id":"A80429","pred":"chebi_id","subj":"T57763","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A26654","pred":"chebi_id","subj":"T37255","obj":"http://purl.obolibrary.org/obo/CHEBI_24261"},{"id":"A52974","pred":"chebi_id","subj":"T90243","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T127","span":{"begin":637,"end":644},"obj":"Phenotype"}],"attributes":[{"id":"A127","pred":"hp_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/HP_0002094"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T402","span":{"begin":0,"end":28},"obj":"Sentence"},{"id":"T403","span":{"begin":29,"end":154},"obj":"Sentence"},{"id":"T404","span":{"begin":155,"end":263},"obj":"Sentence"},{"id":"T405","span":{"begin":264,"end":440},"obj":"Sentence"},{"id":"T406","span":{"begin":441,"end":645},"obj":"Sentence"},{"id":"T407","span":{"begin":646,"end":907},"obj":"Sentence"},{"id":"T408","span":{"begin":908,"end":986},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"854","span":{"begin":205,"end":213},"obj":"Species"},{"id":"855","span":{"begin":155,"end":173},"obj":"Chemical"},{"id":"856","span":{"begin":321,"end":339},"obj":"Chemical"},{"id":"857","span":{"begin":67,"end":71},"obj":"Disease"},{"id":"862","span":{"begin":739,"end":747},"obj":"Species"},{"id":"863","span":{"begin":441,"end":445},"obj":"Disease"},{"id":"864","span":{"begin":637,"end":644},"obj":"Disease"},{"id":"865","span":{"begin":753,"end":757},"obj":"Disease"}],"attributes":[{"id":"A854","pred":"tao:has_database_id","subj":"854","obj":"Tax:9606"},{"id":"A855","pred":"tao:has_database_id","subj":"855","obj":"MESH:D008775"},{"id":"A856","pred":"tao:has_database_id","subj":"856","obj":"MESH:D008775"},{"id":"A857","pred":"tao:has_database_id","subj":"857","obj":"MESH:D012128"},{"id":"A862","pred":"tao:has_database_id","subj":"862","obj":"Tax:9606"},{"id":"A863","pred":"tao:has_database_id","subj":"863","obj":"MESH:D045169"},{"id":"A864","pred":"tao:has_database_id","subj":"864","obj":"MESH:D004417"},{"id":"A865","pred":"tao:has_database_id","subj":"865","obj":"MESH:D045169"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}

{"project":"2_test","denotations":[{"id":"32029004-12899744-70133850","span":{"begin":899,"end":901},"obj":"12899744"},{"id":"32029004-12930669-70133851","span":{"begin":903,"end":905},"obj":"12930669"},{"id":"32029004-15059370-70133852","span":{"begin":982,"end":984},"obj":"15059370"}],"text":"6.3.3 Corticosteroid therapy\nThe use of corticosteroids for severe ARDS is controversial; therefore, systemic use of glucocorticoids needs to be cautious. Methylprednisolone can be used as appropriate for patients with rapid disease progression or severe illness. According to the severity of the disease, 40 to 80 mg of methylprednisolone per day can be considered, and the total daily dose should not exceed 2 mg/kg (Weak recommendation).\nSARS management related researches showed that timely use of non-invasive continuous positive airway pressure and corticosteroids is an effective strategy for increased lung shadows and increased dyspnea. Appropriate use of glucocorticoids is able to significantly improve the clinical symptoms of patients with SARS, reduce the degree of disease progression, and accelerate the absorption of lung lesions; but it cannot shorten the length of hospital stay [35, 36]. Be cautious that hormone therapy has some incidence of adverse reactions [37]."}