PMC:7003341 / 48045-49554 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T208","span":{"begin":429,"end":434},"obj":"Body_part"},{"id":"T209","span":{"begin":457,"end":463},"obj":"Body_part"},{"id":"T210","span":{"begin":1088,"end":1096},"obj":"Body_part"},{"id":"T211","span":{"begin":1120,"end":1128},"obj":"Body_part"},{"id":"T212","span":{"begin":1467,"end":1471},"obj":"Body_part"}],"attributes":[{"id":"A208","pred":"fma_id","subj":"T208","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A209","pred":"fma_id","subj":"T209","obj":"http://purl.org/sig/ont/fma/fma264279"},{"id":"A210","pred":"fma_id","subj":"T210","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A211","pred":"fma_id","subj":"T211","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A212","pred":"fma_id","subj":"T212","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T133","span":{"begin":429,"end":434},"obj":"Body_part"},{"id":"T134","span":{"begin":1467,"end":1471},"obj":"Body_part"}],"attributes":[{"id":"A133","pred":"uberon_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A134","pred":"uberon_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T125","span":{"begin":69,"end":88},"obj":"Disease"},{"id":"T126","span":{"begin":93,"end":128},"obj":"Disease"},{"id":"T127","span":{"begin":99,"end":128},"obj":"Disease"},{"id":"T128","span":{"begin":243,"end":262},"obj":"Disease"},{"id":"T129","span":{"begin":326,"end":363},"obj":"Disease"},{"id":"T130","span":{"begin":346,"end":363},"obj":"Disease"},{"id":"T131","span":{"begin":377,"end":392},"obj":"Disease"},{"id":"T132","span":{"begin":420,"end":442},"obj":"Disease"},{"id":"T133","span":{"begin":524,"end":543},"obj":"Disease"},{"id":"T134","span":{"begin":967,"end":1002},"obj":"Disease"},{"id":"T135","span":{"begin":973,"end":1002},"obj":"Disease"},{"id":"T136","span":{"begin":1231,"end":1235},"obj":"Disease"}],"attributes":[{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A129","pred":"mondo_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A130","pred":"mondo_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A131","pred":"mondo_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/MONDO_0006932"},{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T354","span":{"begin":429,"end":434},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T355","span":{"begin":594,"end":595},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T356","span":{"begin":700,"end":703},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T357","span":{"begin":1305,"end":1311},"obj":"http://purl.obolibrary.org/obo/CLO_0050605"},{"id":"T358","span":{"begin":1327,"end":1335},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T359","span":{"begin":1467,"end":1471},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T360","span":{"begin":1467,"end":1471},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T95","span":{"begin":185,"end":191},"obj":"Chemical"},{"id":"T96","span":{"begin":476,"end":482},"obj":"Chemical"},{"id":"T97","span":{"begin":867,"end":871},"obj":"Chemical"},{"id":"T99","span":{"begin":1008,"end":1012},"obj":"Chemical"}],"attributes":[{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A98","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A100","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T115","span":{"begin":69,"end":88},"obj":"Phenotype"},{"id":"T116","span":{"begin":99,"end":119},"obj":"Phenotype"},{"id":"T117","span":{"begin":243,"end":262},"obj":"Phenotype"},{"id":"T118","span":{"begin":291,"end":302},"obj":"Phenotype"},{"id":"T119","span":{"begin":326,"end":363},"obj":"Phenotype"},{"id":"T120","span":{"begin":377,"end":392},"obj":"Phenotype"},{"id":"T121","span":{"begin":524,"end":543},"obj":"Phenotype"},{"id":"T122","span":{"begin":973,"end":993},"obj":"Phenotype"},{"id":"T123","span":{"begin":1097,"end":1108},"obj":"Phenotype"},{"id":"T124","span":{"begin":1409,"end":1418},"obj":"Phenotype"}],"attributes":[{"id":"A115","pred":"hp_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A116","pred":"hp_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A117","pred":"hp_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A118","pred":"hp_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/HP_0012416"},{"id":"A119","pred":"hp_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A120","pred":"hp_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/HP_0100598"},{"id":"A121","pred":"hp_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A122","pred":"hp_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A123","pred":"hp_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/HP_0100750"},{"id":"A124","pred":"hp_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T381","span":{"begin":0,"end":129},"obj":"Sentence"},{"id":"T382","span":{"begin":130,"end":263},"obj":"Sentence"},{"id":"T383","span":{"begin":264,"end":520},"obj":"Sentence"},{"id":"T384","span":{"begin":521,"end":681},"obj":"Sentence"},{"id":"T385","span":{"begin":682,"end":811},"obj":"Sentence"},{"id":"T386","span":{"begin":812,"end":1205},"obj":"Sentence"},{"id":"T387","span":{"begin":1206,"end":1509},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"793","span":{"begin":1045,"end":1049},"obj":"Chemical"},{"id":"764","span":{"begin":1384,"end":1392},"obj":"Species"},{"id":"765","span":{"begin":1409,"end":1418},"obj":"Disease"},{"id":"785","span":{"begin":47,"end":55},"obj":"Species"},{"id":"786","span":{"begin":223,"end":230},"obj":"Species"},{"id":"787","span":{"begin":278,"end":286},"obj":"Species"},{"id":"788","span":{"begin":934,"end":942},"obj":"Species"},{"id":"789","span":{"begin":1217,"end":1225},"obj":"Species"},{"id":"790","span":{"begin":8,"end":19},"obj":"Species"},{"id":"791","span":{"begin":185,"end":191},"obj":"Chemical"},{"id":"792","span":{"begin":476,"end":482},"obj":"Chemical"},{"id":"794","span":{"begin":61,"end":88},"obj":"Disease"},{"id":"795","span":{"begin":93,"end":128},"obj":"Disease"},{"id":"796","span":{"begin":235,"end":262},"obj":"Disease"},{"id":"797","span":{"begin":291,"end":302},"obj":"Disease"},{"id":"798","span":{"begin":326,"end":363},"obj":"Disease"},{"id":"799","span":{"begin":365,"end":392},"obj":"Disease"},{"id":"800","span":{"begin":420,"end":442},"obj":"Disease"},{"id":"801","span":{"begin":524,"end":543},"obj":"Disease"},{"id":"802","span":{"begin":967,"end":1002},"obj":"Disease"},{"id":"803","span":{"begin":1231,"end":1235},"obj":"Disease"}],"attributes":[{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"Tax:9606"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"MESH:D000860"},{"id":"A785","pred":"tao:has_database_id","subj":"785","obj":"Tax:9606"},{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"Tax:9606"},{"id":"A787","pred":"tao:has_database_id","subj":"787","obj":"Tax:9606"},{"id":"A788","pred":"tao:has_database_id","subj":"788","obj":"Tax:9606"},{"id":"A789","pred":"tao:has_database_id","subj":"789","obj":"Tax:9606"},{"id":"A790","pred":"tao:has_database_id","subj":"790","obj":"Tax:12814"},{"id":"A791","pred":"tao:has_database_id","subj":"791","obj":"MESH:D010100"},{"id":"A792","pred":"tao:has_database_id","subj":"792","obj":"MESH:D010100"},{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"MESH:D012131"},{"id":"A795","pred":"tao:has_database_id","subj":"795","obj":"MESH:D012128"},{"id":"A796","pred":"tao:has_database_id","subj":"796","obj":"MESH:D012131"},{"id":"A797","pred":"tao:has_database_id","subj":"797","obj":"MESH:D006935"},{"id":"A798","pred":"tao:has_database_id","subj":"798","obj":"MESH:D029424"},{"id":"A799","pred":"tao:has_database_id","subj":"799","obj":"MESH:D011654"},{"id":"A800","pred":"tao:has_database_id","subj":"800","obj":"MESH:D009102"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"MESH:D012131"},{"id":"A802","pred":"tao:has_database_id","subj":"802","obj":"MESH:D012128"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Second, respiratory support should be given to patients with hypoxic respiratory failure and acute respiratory distress syndrome. HFNO or NIV can be selected when nasal cannula or mask oxygen therapy was ineffective or the patient had hypoxic respiratory failure. However, when patients had hypercapnia (acute exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary edema), hemodynamic instability, multiple organ failure, and abnormal mental status HFNO oxygen is not the routinely adopted measure. If respiratory failure cannot be improved or worsens continuously within a short time (1 h) after using HFNO or NIV, intubation should be performed immediately. Low tidal volume (4-8 ml/kg) and low suction pressure (platform pressure \u003c 30cmH2O) are used for invasive mechanical ventilation. It is suggested that positive end-expiratory pressure (PEEP) with high positive end-expiratory pressure should be used in patients with moderate or severe acute respiratory distress syndrome, and PEEP should be titrated according to FiO2 to maintain SpO2, in order to improve alveolar atelectasis and reduce alveolar hyper-expansion and pulmonary vascular resistance at the end of inspiration. For severe patients with ARDS, it is recommended to ventilate in prone position for more than 12 h/d. (4) Extracorporeal Membrane Oxygenation (ECMO) should be considered for the patients with refractory hypoxemia that is difficult to be corrected by protective lung ventilation. (Strong recommendation)."}