PMC:6955813 / 6432-7559 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"10145","span":{"begin":20,"end":29},"obj":"SNP"},{"id":"10153","span":{"begin":290,"end":299},"obj":"SNP"}],"attributes":[{"id":"A10145","pred":"resolved_to","subj":"10145","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A10153","pred":"resolved_to","subj":"10153","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"}],"text":"3.2. Association of rs2569190A\u003eG in CD14 with Hypercholesterolemia\nOur calculations showed that the minor allele in our population was the allele G, with a frequency of 0.41 (Table 2). In addition, the allelic frequencies were consistent with HWE (p = 0.86). Interestingly, the G allele of rs2569190 in CD14 was associated with increased levels of Tchol (OR = 3.04, p = 0.016, Table 3) and LDL-C (OR = 3.83, p = 0.006, Table 3) and decreased levels of HDL-C (OR = 0.36, p = 0.001, Table 3). Similar results were also seen with a recessive genetic model. Age was positively associated with an increase in Tchol levels (OR = 2.06 and p = 0.011, Table 3) and LDL-C levels (OR = 2.22 and p = 0.004, Table 3). Similarly, smoking was significantly associated with an increase in Tchol levels (OR = 2.18, p = 0.021, Table 3) and LDL-C (OR = 1.88, p = 0.050, Table 3) and a decrease in HDL-C (OR = 0.41, p = 0.001, Table 3). Participants that practiced physical exercise once per week had decreased Tchol (OR = 0.27 and p = 0.001, Table 3), LDL-C (OR = 0.28 and p = 0.001, Table 3), and HDL-C (OR = 0.40 and p = 0.017, Table 3) levels."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"24914","span":{"begin":20,"end":29},"obj":"SNP"},{"id":"24922","span":{"begin":290,"end":299},"obj":"SNP"},{"id":"T1","span":{"begin":20,"end":29},"obj":"SNP"},{"id":"T1","span":{"begin":290,"end":299},"obj":"SNP"}],"attributes":[{"id":"A24914","pred":"resolved_to","subj":"24914","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A24922","pred":"resolved_to","subj":"24922","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"}],"text":"3.2. Association of rs2569190A\u003eG in CD14 with Hypercholesterolemia\nOur calculations showed that the minor allele in our population was the allele G, with a frequency of 0.41 (Table 2). In addition, the allelic frequencies were consistent with HWE (p = 0.86). Interestingly, the G allele of rs2569190 in CD14 was associated with increased levels of Tchol (OR = 3.04, p = 0.016, Table 3) and LDL-C (OR = 3.83, p = 0.006, Table 3) and decreased levels of HDL-C (OR = 0.36, p = 0.001, Table 3). Similar results were also seen with a recessive genetic model. Age was positively associated with an increase in Tchol levels (OR = 2.06 and p = 0.011, Table 3) and LDL-C levels (OR = 2.22 and p = 0.004, Table 3). Similarly, smoking was significantly associated with an increase in Tchol levels (OR = 2.18, p = 0.021, Table 3) and LDL-C (OR = 1.88, p = 0.050, Table 3) and a decrease in HDL-C (OR = 0.41, p = 0.001, Table 3). Participants that practiced physical exercise once per week had decreased Tchol (OR = 0.27 and p = 0.001, Table 3), LDL-C (OR = 0.28 and p = 0.001, Table 3), and HDL-C (OR = 0.40 and p = 0.017, Table 3) levels."}