PMC:6955813 / 101-1152 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"10071","span":{"begin":281,"end":290},"obj":"SNP"},{"id":"10074","span":{"begin":964,"end":973},"obj":"SNP"},{"id":"10076","span":{"begin":132,"end":141},"obj":"SNP"},{"id":"10083","span":{"begin":625,"end":634},"obj":"SNP"}],"attributes":[{"id":"A10071","pred":"resolved_to","subj":"10071","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A10074","pred":"resolved_to","subj":"10074","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A10076","pred":"resolved_to","subj":"10076","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A10083","pred":"resolved_to","subj":"10083","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"}],"text":"Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A\u003eG with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A\u003eG in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"24841","span":{"begin":281,"end":290},"obj":"SNP"},{"id":"24844","span":{"begin":964,"end":973},"obj":"SNP"},{"id":"24852","span":{"begin":625,"end":634},"obj":"SNP"},{"id":"T1","span":{"begin":281,"end":290},"obj":"SNP"},{"id":"T2","span":{"begin":964,"end":973},"obj":"SNP"},{"id":"T3","span":{"begin":625,"end":634},"obj":"SNP"}],"attributes":[{"id":"A24841","pred":"resolved_to","subj":"24841","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A24844","pred":"resolved_to","subj":"24844","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A24852","pred":"resolved_to","subj":"24852","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs2569190;VariantGroup:3;CorrespondingGene:929;RS#:2569190;CorrespondingSpecies:9606"}],"text":"Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A\u003eG with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A\u003eG in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia."}