PMC:6891841 / 10461-11653 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6891841","sourcedb":"PMC","sourceid":"6891841","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6891841","text":"Many researchers promoted the “SE models” because SE often is noted in the history of patients with TLE. A counterargument is that SE is not extremely common, and the SE model in rodents leads to more brain damage than in TLE. Several modified versions of the original “SE” models were developed to improve them, but arguments continue. Nevertheless, the fact that MTS occurred, it did so long before the epilepsy, and animals with less damage did not develop epilepsy was viewed as strong evidence that brain damage causes epilepsy. Moreover, there were no convulsive seizures between MTS development and then chronic epilepsy in rodents, suggesting there is a “silent” period, as suspected in patients with TLE (Figure 1). The idea of a silent period eventually lost favor when data using video-EEG showed very early epileptiform spikes and bursts after SE that grow in duration and complexity until they ultimately are accompanied by convulsions.40 Notably, other brain insults that are risk factors for TLE have been developed, and there also are genetic models.41 Although each animal model has its critics, there is no question that they have all been a huge boost to epilepsy research.","tracks":[{"project":"0_colil","denotations":[{"id":"31232111-19228963-2416","span":{"begin":949,"end":951},"obj":"19228963"}],"attributes":[{"subj":"31232111-19228963-2416","pred":"source","obj":"0_colil"}]},{"project":"TEST0","denotations":[{"id":"31232111-236-242-2416","span":{"begin":949,"end":951},"obj":"[\"19228963\"]"}],"attributes":[{"subj":"31232111-236-242-2416","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"31232111-19228963-28640014","span":{"begin":949,"end":951},"obj":"19228963"}],"attributes":[{"subj":"31232111-19228963-28640014","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"31232111-19228963-28640014","span":{"begin":949,"end":952},"obj":"19228963"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31232111-19228963-28640014","pred":"source","obj":"MyTest"}]},{"project":"testtesttest","denotations":[{"id":"T100","span":{"begin":201,"end":206},"obj":"Body_part"},{"id":"T102","span":{"begin":504,"end":509},"obj":"Body_part"},{"id":"T104","span":{"begin":967,"end":972},"obj":"Body_part"}],"attributes":[{"id":"A100","pred":"uberon_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A101","pred":"uberon_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"id":"A102","pred":"uberon_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A103","pred":"uberon_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"id":"A104","pred":"uberon_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A105","pred":"uberon_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"subj":"T100","pred":"source","obj":"testtesttest"},{"subj":"T102","pred":"source","obj":"testtesttest"},{"subj":"T104","pred":"source","obj":"testtesttest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"0_colil","color":"#93eca3","default":true},{"id":"TEST0","color":"#ec939c"},{"id":"2_test","color":"#93b6ec"},{"id":"MyTest","color":"#d1ec93"},{"id":"testtesttest","color":"#ec93eb"}]}]}}