PMC:6891830 / 3978-5211
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6891830","sourcedb":"PMC","sourceid":"6891830","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6891830","text":"To address this gap in knowledge, Shandra and colleagues developed a closed-head model of post-traumatic epilepsy in mice following repetitive, mild TBI. Traumatic brain injury was induced by dropping a 100 g weight from a 50 cm height onto the anesthetized mouse’s head, which rested on a foam pad. Three impacts were given at 45-minute intervals. Unimpacted controls were also anesthetized. Animals receiving impacts took about 2 minutes longer to recover from anesthesia than controls—suggestive of brief unconsciousness. Overall mortality was only 4% and significant neuronal loss was absent. Nine animals underwent 24/7 long-term electroencephalogram (EEG) monitoring, and 44% (4 of 9) developed either focal nonconvulsive seizures or convulsive seizures. The earliest seizure occurred 21 days after mild TBI, while the mean latency was 38 days. This is well outside the clinically defined 1 week period during which acute, nonepileptic injury-induced seizures occur following TBI. Convulsive seizures were associated with behavioral changes, including Racine scale class V “rearing and falling.”3 The combination of EEG and behavioral manifestations in these animals provides convincing evidence that the mice became epileptic.","tracks":[{"project":"TEST0","denotations":[{"id":"31208231-237-242-3770","span":{"begin":1101,"end":1102},"obj":"[\"4110397\"]"}],"attributes":[{"subj":"31208231-237-242-3770","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"31208231-4110397-3770","span":{"begin":1101,"end":1102},"obj":"4110397"}],"attributes":[{"subj":"31208231-4110397-3770","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"31208231-4110397-28640715","span":{"begin":1101,"end":1102},"obj":"4110397"}],"attributes":[{"subj":"31208231-4110397-28640715","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"31208231-4110397-28640715","span":{"begin":1101,"end":1103},"obj":"4110397"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31208231-4110397-28640715","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#d893ec","default":true},{"id":"0_colil","color":"#93ecbe"},{"id":"2_test","color":"#eca493"},{"id":"MyTest","color":"#939bec"}]}]}}