PMC:6879884 / 14753-15465 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6879884","sourcedb":"PMC","sourceid":"6879884","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6879884","text":"Hexokinase activity is inhibited by 3-bromopyruvic acid (BrPy). A: effect of BrPy concentration on hexokinase activity in cell extracts from H441 cells exposed to 5 mM glucose. The dose-response data did not follow a classic sigmoid curve, and there was an indication that the inhibition was biphasic. Two curves could be fitted to the data to reflect initial inhibition (left-hand curve) with an IC50 of 0.04 ± 0.01 mM or overall inhibition (right-hand side) with an IC50 of 1.2 ± 0.28 mM (n = 4 experiments). B: total hexokinase activity in cell extracts from control (●) or BrPy (100 μM)-treated cells (○). Individual data points are shown with mean ± SD. ****Significantly different from control, P \u003c 0.0001.","tracks":[]}