PMC:6736480 / 21748-22898 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6736480","sourcedb":"PMC","sourceid":"6736480","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6736480","text":"On the contrary, many clinicians still argue that local excision of the residual scar after preoperative CRT is a much safer approach than a wait-and-see policy, because it provides reassurance about the presence or absence of remnant tumor. Although it is undoubtedly true that it accurately provides more opportunity to assess the tumor remnant, it could be a challenge for the surgeon to identify the precise site of the initial tumor needed to achieve an adequate resection margin, because scarring changes of the primary tumor with unclear landmarks make it difficult to identify microscopic residual tumor. From a similar point of view, this study showed that none of 3 modalities had reliable PPVs to distinguish ypT0-1 from ypT3-4. Furthermore, a few studies reported that there was a still 5.0% to 10.0% incidence of positive lymph nodes in ypT0-1 patients,[2,28–31] and there is no clear consensus about the standard criteria to determine lymph node positivity. Therefore, when considering local excision or nonoperative treatment, treatment strategy should be cautiously determined due to the risk of leaving positive regional lymph nodes.","tracks":[{"project":"2_test","denotations":[{"id":"31464897-20692872-68392322","span":{"begin":867,"end":868},"obj":"20692872"},{"id":"31464897-16273666-68392323","span":{"begin":869,"end":871},"obj":"16273666"},{"id":"31464897-18043968-68392323","span":{"begin":869,"end":871},"obj":"18043968"},{"id":"31464897-16532432-68392323","span":{"begin":869,"end":871},"obj":"16532432"},{"id":"31464897-16450221-68392323","span":{"begin":869,"end":871},"obj":"16450221"}],"attributes":[{"subj":"31464897-20692872-68392322","pred":"source","obj":"2_test"},{"subj":"31464897-16273666-68392323","pred":"source","obj":"2_test"},{"subj":"31464897-18043968-68392323","pred":"source","obj":"2_test"},{"subj":"31464897-16532432-68392323","pred":"source","obj":"2_test"},{"subj":"31464897-16450221-68392323","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93b5","default":true}]}]}}