PMC:6723693 / 57805-58668 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6723693","sourcedb":"PMC","sourceid":"6723693","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6723693","text":"All the studies summarized thus far confirmed C22G1 as the most effective amphiphilic dendron, which self-assembles into spherical micelles at very low concentration and is able to bind heparin with very high affinity (CE50 = 0.28)—decidedly higher than protamine (EC50 = 0.52)—in buffered solutions at physiological ionic strength (Section 3.1.1). However, the C22G1 self-assembled dendrimers show some weakness when tested in a more clinically-relevant environment such as human serum (CE50 = 0.96), underperforming with respect to the current clinical heparin antidote (CE50 = 0.76, Table 1). In this respect, we speculated that kinetic micellar instability and the subsequent interaction of the alkyl chain with the most abundant serum protein (i.e., human serum albumin, HSA) could lead to C22G1 micelles disassembly and, ultimately, loss of heparin binding.","tracks":[]}