PMC:6723693 / 47707-48654 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6723693","sourcedb":"PMC","sourceid":"6723693","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6723693","text":"As for C16G0 (see Section 3.2), multiscale molecular simulations carried out in a solvated environment containing 150 mM NaCl anticipated the aggregation of both new molecules in spherical micelles (Figure 10b), with Dm values of 6.3 ± 0.1 and 5.8 ± 0.2 nm for C16SPD, and C16SPM, respectively, and Nagg decreasing in the order (C16G0 (16) \u003e) C16SPD (13) \u003e C16SPM (10). Evidently, the C16 alkyl chain is optimized for the G0 head and is less effective in packing the longer (SPD) and/or more charged SPM ligands. As a consequence of the decrease in Nagg, the predicted self-assembled dendrimers electrostatic potential Ψ also decreased in the same order (172.4, 153.3, and 144.6 mV), resulting in the corresponding z-potential values of 50.2, 45.1, and 41.8 mV, respectively. DLS confirmed the modeling data, with Dm and ζ-potential values of 6.6 ± 0.2 nm and +44.0 ± 1.7 mV for C16SPD and 6.2 ± 0.1 nm and +40.5 ± 0.9 mV for C16SPM, respectively.","tracks":[]}