PMC:6723693 / 45023-46362 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6723693","sourcedb":"PMC","sourceid":"6723693","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6723693","text":"In a conclusive effort, experimental (SAXS) and computational data for both self-assembled dendrimers in complex with heparin were compared with the corresponding TEM images, as shown in Figure 9c. The top left panel in this Figure illustrates the crystal projection view along the [110] zone axis. The analysis of the linear profile over the crystal projection (red double pointed arrow) yielded an average period (ap) of 4.5 nm, corresponding to fcc lattice constant values of 7.8 and 8.0 nm for C14G0 and C16G0 nanoassemblies, respectively. These values agree with those derived from simulation and SAXS reported above, the minor reduction in the cell unit size being ascribable to the drying effect on the TEM grid. The Fast Fourier (FF) transforms of the crystalline area and the subsequent selected filtered inverse FF transforms yielded the representative image of the crystal cell (Figure 9c, bottom row, left). The fcc arrangement of the micelles was confirmed by superposing this image with the corresponding unit cell model (Figure 9c, bottom row, center). Finally, the micelle center-to-center distance values of 5.5 nm and 5.6 nm estimated for C14G0 and C16G0, respectively (Figure 9c, bottom row, right), are in good agreement both with those obtained by computer simulations and with the micellar diameters estimated by DLS.","tracks":[]}