PMC:6707402 / 18431-20531 JSONTXT

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5. Dermatological and allergic adverse reactions observed per number of patients.\nAdverse reactions Studies Total patients, n Patients with adverse reactions, n (%) (%, min-max) †\nSkin reactions\n   Erythema ‡ [ 19, 32, 64, 66, 82, 95] 2352 201 (9) (3–95) [ 95] - [ 82]\n   Itching/Pruritus ‡ [ 6, 55, 57, 64, 66, 72, 82, 93] 3421 215 (6) (0–70) [ 55] - [ 82]\n   Urticaria ‡ [ 24, 31, 83] 58 9 (16) (4–59) [ 24] - [ 83]\n   Rash [ 29, 30, 55, 57, 64, 93, 101, 111] 2682 121 (5) (1–40) [ 30] - [ 93]\n   Paresthesia/burning or stinging sensation § ‡ [ 17, 21, 24, 28, 30, 44, 45, 55, 57, 67, 69, 79, 91, 93, 106] 2141 335 (16) (0–100) [ 30] - [ 45]\n   Scaling of skin/desquamation/ dry skin/local irritant ‡ [ 22, 29, 30, 37, 52, 55, 57, 64, 66, 69, 75, 82, 88, 89, 106] 4739 731 (15) (1–96) [ 66] - [ 52]\n   Blistering ‡ [ 31, 32, 66, 69, 93, 112] 2038 79 (4) (3–20) [ 66] - [ 112]\n   Roughness and/or thickening of skin ‡ [ 66, 82, 93] 1986 191 (10) (6–10) [ 93] - [ 82]\n   Bullous dermatitis/dermatitis with vesicles ‡ [ 20, 29, 64] 1116 79 (7) (1–9) [ 64] - [ 29]\n   Contact dermatitis ‡ [ 6, 20, 28– 30, 64, 111] 2587 161 (6) (1–13) [ 28] - [ 29]\n   Skin reaction, unspecified ‡ [ 2, 78, 96, 113] 457 159 (35) (4–48) [ 96] - [ 113]\n   Increase in skin pigmentation ‡ [ 6] 548 28 (5)\n   Peripheral edema ‡ [ 45, 55, 66, 109] 2291 22 (0) (1–14) [ 66] - [ 109]\nAllergic reactions [ 37, 44, 59, 86, 98, 110] 309 75 (24) (3–55) [ 44, 110] - [ 86]\n  Intravenous administration [ 59, 86, 98, 110] 229 66 (29) (2–55) [ 59] - [ 86]\n  Transdermal application [ 37, 44] 86 9 (10) (3–19) [ 44] - [ 37]\n  Flushing ¶ [ 41, 54, 73] 292 34 (12) (2–9) [ 54] - [ 73]\n†Incidences of the adverse reactions have been calculated for all the individual studies. (min%–max%) are the lowest and highest observed incidence of an adverse reaction observed in the group of studies included.\n‡ Transdermal application only.\n§ One study administered DMSO through intraarticular injection [ 38].\n¶ DMSO was administered intravenously in all studies."}

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5. Dermatological and allergic adverse reactions observed per number of patients.\nAdverse reactions Studies Total patients, n Patients with adverse reactions, n (%) (%, min-max) †\nSkin reactions\n   Erythema ‡ [ 19, 32, 64, 66, 82, 95] 2352 201 (9) (3–95) [ 95] - [ 82]\n   Itching/Pruritus ‡ [ 6, 55, 57, 64, 66, 72, 82, 93] 3421 215 (6) (0–70) [ 55] - [ 82]\n   Urticaria ‡ [ 24, 31, 83] 58 9 (16) (4–59) [ 24] - [ 83]\n   Rash [ 29, 30, 55, 57, 64, 93, 101, 111] 2682 121 (5) (1–40) [ 30] - [ 93]\n   Paresthesia/burning or stinging sensation § ‡ [ 17, 21, 24, 28, 30, 44, 45, 55, 57, 67, 69, 79, 91, 93, 106] 2141 335 (16) (0–100) [ 30] - [ 45]\n   Scaling of skin/desquamation/ dry skin/local irritant ‡ [ 22, 29, 30, 37, 52, 55, 57, 64, 66, 69, 75, 82, 88, 89, 106] 4739 731 (15) (1–96) [ 66] - [ 52]\n   Blistering ‡ [ 31, 32, 66, 69, 93, 112] 2038 79 (4) (3–20) [ 66] - [ 112]\n   Roughness and/or thickening of skin ‡ [ 66, 82, 93] 1986 191 (10) (6–10) [ 93] - [ 82]\n   Bullous dermatitis/dermatitis with vesicles ‡ [ 20, 29, 64] 1116 79 (7) (1–9) [ 64] - [ 29]\n   Contact dermatitis ‡ [ 6, 20, 28– 30, 64, 111] 2587 161 (6) (1–13) [ 28] - [ 29]\n   Skin reaction, unspecified ‡ [ 2, 78, 96, 113] 457 159 (35) (4–48) [ 96] - [ 113]\n   Increase in skin pigmentation ‡ [ 6] 548 28 (5)\n   Peripheral edema ‡ [ 45, 55, 66, 109] 2291 22 (0) (1–14) [ 66] - [ 109]\nAllergic reactions [ 37, 44, 59, 86, 98, 110] 309 75 (24) (3–55) [ 44, 110] - [ 86]\n  Intravenous administration [ 59, 86, 98, 110] 229 66 (29) (2–55) [ 59] - [ 86]\n  Transdermal application [ 37, 44] 86 9 (10) (3–19) [ 44] - [ 37]\n  Flushing ¶ [ 41, 54, 73] 292 34 (12) (2–9) [ 54] - [ 73]\n†Incidences of the adverse reactions have been calculated for all the individual studies. (min%–max%) are the lowest and highest observed incidence of an adverse reaction observed in the group of studies included.\n‡ Transdermal application only.\n§ One study administered DMSO through intraarticular injection [ 38].\n¶ DMSO was administered intravenously in all studies."}