PMC:6707402 / 13453-14653 JSONTXT

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reaction Studies Total patients, n Patients with adverse reactions, n (%) (min%–max%) †\nCardiac\n   Hypotension ‡ [ 7, 18, 23, 33, 71, 73, 87, 104, 115] 2752 115 (4) (1–14) [ 18, 71] - [ 87]\n   Hypertension § [ 7, 18, 23, 33, 41, 54, 61, 73, 85, 87, 102] 2998 385 (13) (2–95) [ 85] - [ 61]\n   Bradycardia (mild and severe) ‡ [ 23, 36, 54, 61, 65, 85, 90, 91, 115, 117] 882 94 (11) (0–49) [ 36] - [ 61]\n   Decrease in heart rate ‡ [ 41, 54, 61, 80] 193 152 (79) (11–94) [ 80] - [ 41]\n   Tachycardia ‡ [ 23, 27, 36] 565 13 (2) (0–6) [ 36] - [ 23]\n   Ventricular extrasystoles ‡ [ 73] 22 11 (50)\n   Cardiac event, unspecified ‡ [ 26, 86] 165 18 (11) (5–12) [ 26] - [ 86]\n   Asystole ¶ [ 91, 100] 45 3 (7) (3–20) [ 100] - [ 91]\n   Left cardiac insufficiency [ 85] 194 1 (1)\n   Chest discomfort/tightness ‡ [ 18, 27, 54, 73, 87, 91, 115] 901 22 (2) (1–10) [ 27] - [ 54]\nRespiratory\n   Unspecified respiratory symptoms ‡ [ 26, 86] 165 43 (26) (21–62) [ 86] - [ 26]\n   Dyspnea d [ 18, 27, 54, 66, 85] 2748 26 (1) (0–10) [ 66] - [ 54]\n   Cough [ 85, 101] 373 52 (14) (5–22) [ 101] [ 85]\n   Lung edema ‡ [ 59, 85] 241 3 (1) (1–2) [ 85] - [ 59]"}

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reaction Studies Total patients, n Patients with adverse reactions, n (%) (min%–max%) †\nCardiac\n   Hypotension ‡ [ 7, 18, 23, 33, 71, 73, 87, 104, 115] 2752 115 (4) (1–14) [ 18, 71] - [ 87]\n   Hypertension § [ 7, 18, 23, 33, 41, 54, 61, 73, 85, 87, 102] 2998 385 (13) (2–95) [ 85] - [ 61]\n   Bradycardia (mild and severe) ‡ [ 23, 36, 54, 61, 65, 85, 90, 91, 115, 117] 882 94 (11) (0–49) [ 36] - [ 61]\n   Decrease in heart rate ‡ [ 41, 54, 61, 80] 193 152 (79) (11–94) [ 80] - [ 41]\n   Tachycardia ‡ [ 23, 27, 36] 565 13 (2) (0–6) [ 36] - [ 23]\n   Ventricular extrasystoles ‡ [ 73] 22 11 (50)\n   Cardiac event, unspecified ‡ [ 26, 86] 165 18 (11) (5–12) [ 26] - [ 86]\n   Asystole ¶ [ 91, 100] 45 3 (7) (3–20) [ 100] - [ 91]\n   Left cardiac insufficiency [ 85] 194 1 (1)\n   Chest discomfort/tightness ‡ [ 18, 27, 54, 73, 87, 91, 115] 901 22 (2) (1–10) [ 27] - [ 54]\nRespiratory\n   Unspecified respiratory symptoms ‡ [ 26, 86] 165 43 (26) (21–62) [ 86] - [ 26]\n   Dyspnea d [ 18, 27, 54, 66, 85] 2748 26 (1) (0–10) [ 66] - [ 54]\n   Cough [ 85, 101] 373 52 (14) (5–22) [ 101] [ 85]\n   Lung edema ‡ [ 59, 85] 241 3 (1) (1–2) [ 85] - [ 59]"}