PMC:6707402 / 13361-15314
Annnotations
MyTest
{"project":"MyTest","denotations":[{"id":"31489176-24964911-30448163","span":{"begin":220,"end":221},"obj":"24964911"},{"id":"31489176-20840341-30448164","span":{"begin":223,"end":225},"obj":"20840341"},{"id":"31489176-25545727-30448165","span":{"begin":227,"end":229},"obj":"25545727"},{"id":"31489176-29269805-30448166","span":{"begin":231,"end":233},"obj":"29269805"},{"id":"31489176-1853447-30448167","span":{"begin":235,"end":237},"obj":"1853447"},{"id":"31489176-9891544-30448168","span":{"begin":239,"end":241},"obj":"9891544"},{"id":"31489176-10217182-30448169","span":{"begin":243,"end":245},"obj":"10217182"},{"id":"31489176-18980622-30448170","span":{"begin":247,"end":250},"obj":"18980622"},{"id":"31489176-17889361-30448171","span":{"begin":252,"end":255},"obj":"17889361"},{"id":"31489176-20840341-30448172","span":{"begin":282,"end":284},"obj":"20840341"},{"id":"31489176-1853447-30448173","span":{"begin":286,"end":288},"obj":"1853447"},{"id":"31489176-10217182-30448174","span":{"begin":294,"end":296},"obj":"10217182"},{"id":"31489176-24964911-30448175","span":{"begin":319,"end":320},"obj":"24964911"},{"id":"31489176-20840341-30448176","span":{"begin":322,"end":324},"obj":"20840341"},{"id":"31489176-25545727-30448177","span":{"begin":326,"end":328},"obj":"25545727"},{"id":"31489176-29269805-30448178","span":{"begin":330,"end":332},"obj":"29269805"},{"id":"31489176-2308999-30448179","span":{"begin":334,"end":336},"obj":"2308999"},{"id":"31489176-2297578-30448180","span":{"begin":338,"end":340},"obj":"2297578"},{"id":"31489176-1464006-30448181","span":{"begin":342,"end":344},"obj":"1464006"},{"id":"31489176-9891544-30448182","span":{"begin":346,"end":348},"obj":"9891544"},{"id":"31489176-17236813-30448183","span":{"begin":350,"end":352},"obj":"17236813"},{"id":"31489176-10217182-30448184","span":{"begin":354,"end":356},"obj":"10217182"},{"id":"31489176-19550404-30448185","span":{"begin":358,"end":361},"obj":"19550404"},{"id":"31489176-17236813-30448186","span":{"begin":389,"end":391},"obj":"17236813"},{"id":"31489176-1464006-30448187","span":{"begin":397,"end":399},"obj":"1464006"},{"id":"31489176-25545727-30448188","span":{"begin":439,"end":441},"obj":"25545727"},{"id":"31489176-15847663-30448189","span":{"begin":443,"end":445},"obj":"15847663"},{"id":"31489176-2297578-30448190","span":{"begin":447,"end":449},"obj":"2297578"},{"id":"31489176-1464006-30448191","span":{"begin":451,"end":453},"obj":"1464006"},{"id":"31489176-18514454-30448192","span":{"begin":455,"end":457},"obj":"18514454"},{"id":"31489176-17236813-30448193","span":{"begin":459,"end":461},"obj":"17236813"},{"id":"31489176-8823452-30448194","span":{"begin":463,"end":465},"obj":"8823452"},{"id":"31489176-21994285-30448195","span":{"begin":467,"end":469},"obj":"21994285"},{"id":"31489176-17889361-30448196","span":{"begin":471,"end":474},"obj":"17889361"},{"id":"31489176-8900855-30448197","span":{"begin":476,"end":479},"obj":"8900855"},{"id":"31489176-15847663-30448198","span":{"begin":505,"end":507},"obj":"15847663"},{"id":"31489176-1464006-30448199","span":{"begin":513,"end":515},"obj":"1464006"},{"id":"31489176-2308999-30448200","span":{"begin":548,"end":550},"obj":"2308999"},{"id":"31489176-2297578-30448201","span":{"begin":552,"end":554},"obj":"2297578"},{"id":"31489176-1464006-30448202","span":{"begin":556,"end":558},"obj":"1464006"},{"id":"31489176-20377980-30448203","span":{"begin":560,"end":562},"obj":"20377980"},{"id":"31489176-20377980-30448204","span":{"begin":590,"end":592},"obj":"20377980"},{"id":"31489176-2308999-30448205","span":{"begin":598,"end":600},"obj":"2308999"},{"id":"31489176-25545727-30448206","span":{"begin":622,"end":624},"obj":"25545727"},{"id":"31489176-19041066-30448207","span":{"begin":626,"end":628},"obj":"19041066"},{"id":"31489176-15847663-30448208","span":{"begin":630,"end":632},"obj":"15847663"},{"id":"31489176-15847663-30448209","span":{"begin":656,"end":658},"obj":"15847663"},{"id":"31489176-25545727-30448210","span":{"begin":664,"end":666},"obj":"25545727"},{"id":"31489176-9891544-30448211","span":{"begin":702,"end":704},"obj":"9891544"},{"id":"31489176-14750079-30448212","span":{"begin":754,"end":756},"obj":"14750079"},{"id":"31489176-17906706-30448213","span":{"begin":758,"end":760},"obj":"17906706"},{"id":"31489176-14750079-30448214","span":{"begin":786,"end":788},"obj":"14750079"},{"id":"31489176-17906706-30448215","span":{"begin":794,"end":796},"obj":"17906706"},{"id":"31489176-21994285-30448216","span":{"begin":815,"end":817},"obj":"21994285"},{"id":"31489176-22550096-30448217","span":{"begin":819,"end":822},"obj":"22550096"},{"id":"31489176-22550096-30448218","span":{"begin":845,"end":848},"obj":"22550096"},{"id":"31489176-21994285-30448219","span":{"begin":854,"end":856},"obj":"21994285"},{"id":"31489176-17236813-30448220","span":{"begin":891,"end":893},"obj":"17236813"},{"id":"31489176-20840341-30448221","span":{"begin":942,"end":944},"obj":"20840341"},{"id":"31489176-19041066-30448222","span":{"b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3. Cardiovascular and respiratory adverse reactions observed per number of patients.\nAdverse reaction Studies Total patients, n Patients with adverse reactions, n (%) (min%–max%) †\nCardiac\n Hypotension ‡ [ 7, 18, 23, 33, 71, 73, 87, 104, 115] 2752 115 (4) (1–14) [ 18, 71] - [ 87]\n Hypertension § [ 7, 18, 23, 33, 41, 54, 61, 73, 85, 87, 102] 2998 385 (13) (2–95) [ 85] - [ 61]\n Bradycardia (mild and severe) ‡ [ 23, 36, 54, 61, 65, 85, 90, 91, 115, 117] 882 94 (11) (0–49) [ 36] - [ 61]\n Decrease in heart rate ‡ [ 41, 54, 61, 80] 193 152 (79) (11–94) [ 80] - [ 41]\n Tachycardia ‡ [ 23, 27, 36] 565 13 (2) (0–6) [ 36] - [ 23]\n Ventricular extrasystoles ‡ [ 73] 22 11 (50)\n Cardiac event, unspecified ‡ [ 26, 86] 165 18 (11) (5–12) [ 26] - [ 86]\n Asystole ¶ [ 91, 100] 45 3 (7) (3–20) [ 100] - [ 91]\n Left cardiac insufficiency [ 85] 194 1 (1)\n Chest discomfort/tightness ‡ [ 18, 27, 54, 73, 87, 91, 115] 901 22 (2) (1–10) [ 27] - [ 54]\nRespiratory\n Unspecified respiratory symptoms ‡ [ 26, 86] 165 43 (26) (21–62) [ 86] - [ 26]\n Dyspnea d [ 18, 27, 54, 66, 85] 2748 26 (1) (0–10) [ 66] - [ 54]\n Cough [ 85, 101] 373 52 (14) (5–22) [ 101] [ 85]\n Lung edema ‡ [ 59, 85] 241 3 (1) (1–2) [ 85] - [ 59]\n†Incidences of the adverse reactions have been calculated for all the individual studies. (min%–max%) are the lowest and highest observed incidence of an adverse reaction.\n‡ DMSO was administered intravenously in all studies.\n§ DMSO was administered intravenously in all studies. Horacek et al. [ 102] measured 42 patients with an increase in systolic blood pressure, and 31 patients with an increase in diastolic blood pressure. This was counted as 73 cases of hypertension.\n¶ In both studies, asystole occurred because of DMSO effect on the trigeminal nerve and activation of the trigeminal cardiac reflex. d) in one study DMSO was administered transdermally"}
2_test
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3. Cardiovascular and respiratory adverse reactions observed per number of patients.\nAdverse reaction Studies Total patients, n Patients with adverse reactions, n (%) (min%–max%) †\nCardiac\n Hypotension ‡ [ 7, 18, 23, 33, 71, 73, 87, 104, 115] 2752 115 (4) (1–14) [ 18, 71] - [ 87]\n Hypertension § [ 7, 18, 23, 33, 41, 54, 61, 73, 85, 87, 102] 2998 385 (13) (2–95) [ 85] - [ 61]\n Bradycardia (mild and severe) ‡ [ 23, 36, 54, 61, 65, 85, 90, 91, 115, 117] 882 94 (11) (0–49) [ 36] - [ 61]\n Decrease in heart rate ‡ [ 41, 54, 61, 80] 193 152 (79) (11–94) [ 80] - [ 41]\n Tachycardia ‡ [ 23, 27, 36] 565 13 (2) (0–6) [ 36] - [ 23]\n Ventricular extrasystoles ‡ [ 73] 22 11 (50)\n Cardiac event, unspecified ‡ [ 26, 86] 165 18 (11) (5–12) [ 26] - [ 86]\n Asystole ¶ [ 91, 100] 45 3 (7) (3–20) [ 100] - [ 91]\n Left cardiac insufficiency [ 85] 194 1 (1)\n Chest discomfort/tightness ‡ [ 18, 27, 54, 73, 87, 91, 115] 901 22 (2) (1–10) [ 27] - [ 54]\nRespiratory\n Unspecified respiratory symptoms ‡ [ 26, 86] 165 43 (26) (21–62) [ 86] - [ 26]\n Dyspnea d [ 18, 27, 54, 66, 85] 2748 26 (1) (0–10) [ 66] - [ 54]\n Cough [ 85, 101] 373 52 (14) (5–22) [ 101] [ 85]\n Lung edema ‡ [ 59, 85] 241 3 (1) (1–2) [ 85] - [ 59]\n†Incidences of the adverse reactions have been calculated for all the individual studies. (min%–max%) are the lowest and highest observed incidence of an adverse reaction.\n‡ DMSO was administered intravenously in all studies.\n§ DMSO was administered intravenously in all studies. Horacek et al. [ 102] measured 42 patients with an increase in systolic blood pressure, and 31 patients with an increase in diastolic blood pressure. This was counted as 73 cases of hypertension.\n¶ In both studies, asystole occurred because of DMSO effect on the trigeminal nerve and activation of the trigeminal cardiac reflex. d) in one study DMSO was administered transdermally"}