PMC:6705340 / 18824-20434 JSONTXT

{"project":"2_test","denotations":[{"id":"31433001-20877947-392802","span":{"begin":174,"end":176},"obj":"20877947"},{"id":"31433001-18797685-392803","span":{"begin":296,"end":298},"obj":"18797685"},{"id":"31433001-19705025-392804","span":{"begin":533,"end":535},"obj":"19705025"},{"id":"31433001-20877947-392805","span":{"begin":536,"end":538},"obj":"20877947"},{"id":"31433001-3940799-392806","span":{"begin":979,"end":981},"obj":"3940799"},{"id":"31433001-8536508-392807","span":{"begin":983,"end":985},"obj":"8536508"}],"text":"One study showed that in the colonic mucosa without a fecal stream, the tissue content of sialomucins decreased, and this reduction was related to the time of fecal exclusion27 . Gastric restriction substantially reduces the supply of fibers to the colon, thereby reducing the production of SCFAs26. This lower supply of SCFAs to the colonic mucosa, the main substrate for epithelial cells, causes less mucin production, as demonstrated by studies that measured the glycoprotein content in the colonic mucosa devoid of a fecal stream22,27. In this study, it is possible that we did not find modifications in the tissue content of sialomucins because a phytobezoar does not completely prevent the passage of SCFAs into the colon, thus maintaining a content of sialomucins similar to that of the sham group. Additionally, under germfree conditions, the ratio of neutral to acidic mucins in the colon is higher, and sulfomucins appear to increase at the expense of sialylated mucins48,-51. Similar to other authors who studied the tissue content of sialomucins in the colonic mucosa devoid of a fecal stream, we also found a lower expression of sialomucins and no difference in sulfomucins. It is likely that due to the incomplete absence of food, the acid mucins were not reshaped, but the goblet cells that express the sulfomucins were enhanced. This phenomenon could be triggered by the food restriction at the time. In general, trophism is conserved with the enhancement of neutral mucins. Collagen was enhanced in the restrict group, probably due to the inflammatory process triggered by gastric restriction."}