PMC:6705340 / 15929-16988 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6705340","sourcedb":"PMC","sourceid":"6705340","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6705340","text":"Experimental studies have shown a reduction in height of the colonic glands in the colonic mucosa devoid of the fecal stream26. The authors suggest that a lack of SCFA supply and the oxidative stress in the colonic mucosa without a fecal stream are the main factors associated with colonic gland atrophy. In this study, we found that after 10 days of gastric restriction, the height of the crypts in general decreased compared to the sham and control groups. This has also occurred in experimental models of diversion colitis, where food restriction due to a phytobezoar probably led to the atrophy of the colonic glands. Interestingly, no differences were seen in the number of goblet cells. Controversies exist regarding the population of cells in colonic segments devoid of the fecal stream37,38. It is possible that the different results found in relation to the goblet cell population in the colonic mucosa restricting the regular supply of SCFAs may be related to the different exclusion times adopted in the experiment durations of different studies22.","tracks":[{"project":"2_test","denotations":[{"id":"31433001-18797685-392782","span":{"begin":124,"end":126},"obj":"18797685"},{"id":"31433001-9075761-392783","span":{"begin":793,"end":795},"obj":"9075761"},{"id":"31433001-22664521-392784","span":{"begin":796,"end":798},"obj":"22664521"},{"id":"31433001-19705025-392785","span":{"begin":1056,"end":1058},"obj":"19705025"}],"attributes":[{"subj":"31433001-18797685-392782","pred":"source","obj":"2_test"},{"subj":"31433001-9075761-392783","pred":"source","obj":"2_test"},{"subj":"31433001-22664521-392784","pred":"source","obj":"2_test"},{"subj":"31433001-19705025-392785","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#cc93ec","default":true}]}]}}