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{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6705338","sourcedb":"PMC","sourceid":"6705338","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6705338","text":"An appropriate biological response favors a healthy biointegration of the tissue capable of determining a greater flexibility of the prosthesis and respect for anisotropy of the abdominal wall, less probability of hernia recurrence, and chronic pain. On the other hand, an excessive integration response results in a greater retraction and hardening of the mesh, as well as a greater likelihood of hernia recurrence, chronic pain, adhesions, and fistulas. Therefore, the success of a synthetic mesh implant depends essentially on the dual-handed pathway established between the mesh and the tissue9-28.","tracks":[{"project":"2_test","denotations":[{"id":"31432994-26671827-396061","span":{"begin":597,"end":598},"obj":"26671827"},{"id":"31432994-29754616-396061","span":{"begin":597,"end":598},"obj":"29754616"},{"id":"31432994-23137644-396061","span":{"begin":597,"end":598},"obj":"23137644"},{"id":"31432994-26537141-396061","span":{"begin":597,"end":598},"obj":"26537141"},{"id":"31432994-20401733-396061","span":{"begin":597,"end":598},"obj":"20401733"},{"id":"31432994-29265400-396061","span":{"begin":597,"end":598},"obj":"29265400"},{"id":"31432994-21898010-396061","span":{"begin":597,"end":598},"obj":"21898010"},{"id":"31432994-23549771-396061","span":{"begin":597,"end":598},"obj":"23549771"},{"id":"31432994-29236795-396061","span":{"begin":597,"end":598},"obj":"29236795"},{"id":"31432994-28300876-396061","span":{"begin":597,"end":598},"obj":"28300876"},{"id":"31432994-20877952-396061","span":{"begin":597,"end":598},"obj":"20877952"},{"id":"31432994-20676491-396061","span":{"begin":597,"end":598},"obj":"20676491"},{"id":"31432994-20011834-396061","span":{"begin":597,"end":598},"obj":"20011834"},{"id":"31432994-17824966-396061","span":{"begin":597,"end":598},"obj":"17824966"},{"id":"31432994-29513808-396061","span":{"begin":597,"end":598},"obj":"29513808"},{"id":"31432994-22836567-396061","span":{"begin":597,"end":598},"obj":"22836567"},{"id":"31432994-27757549-396061","span":{"begin":597,"end":598},"obj":"27757549"},{"id":"31432994-29864263-396061","span":{"begin":597,"end":598},"obj":"29864263"}],"attributes":[{"subj":"31432994-26671827-396061","pred":"source","obj":"2_test"},{"subj":"31432994-29754616-396061","pred":"source","obj":"2_test"},{"subj":"31432994-23137644-396061","pred":"source","obj":"2_test"},{"subj":"31432994-26537141-396061","pred":"source","obj":"2_test"},{"subj":"31432994-20401733-396061","pred":"source","obj":"2_test"},{"subj":"31432994-29265400-396061","pred":"source","obj":"2_test"},{"subj":"31432994-21898010-396061","pred":"source","obj":"2_test"},{"subj":"31432994-23549771-396061","pred":"source","obj":"2_test"},{"subj":"31432994-29236795-396061","pred":"source","obj":"2_test"},{"subj":"31432994-28300876-396061","pred":"source","obj":"2_test"},{"subj":"31432994-20877952-396061","pred":"source","obj":"2_test"},{"subj":"31432994-20676491-396061","pred":"source","obj":"2_test"},{"subj":"31432994-20011834-396061","pred":"source","obj":"2_test"},{"subj":"31432994-17824966-396061","pred":"source","obj":"2_test"},{"subj":"31432994-29513808-396061","pred":"source","obj":"2_test"},{"subj":"31432994-22836567-396061","pred":"source","obj":"2_test"},{"subj":"31432994-27757549-396061","pred":"source","obj":"2_test"},{"subj":"31432994-29864263-396061","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9396ec","default":true}]}]}}