PMC:6705338 / 14132-20817
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6705338","sourcedb":"PMC","sourceid":"6705338","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6705338","text":"Results\nThere were no statistically significant differences in initial (D1) and final (D21) weight of the animals among the three groups according to the ANOVA test (p value=0.652 for the initial weight, and p value=0.736 for the final weight). However, in all groups, there was a significant increase in the weight of the animals at the end of the study (D21) compared to the weight of the animals at the beginning (D1), according to the ANOVA test (p value\u003c0.0001). The mean initial weight of the animals was 307 ± 33 g, and the mean final weight of the animals was 349 ± 35 g.\nIn all groups, there were postoperative complications, with emphasis on partial dehiscence of the operative wound, which was diagnosed between postoperative D7 and D9. However, there were no significant differences between groups (Table 2). At the end of the study, three animals had meshoma, one in the polypropylene/polyglecaprone group and two in the polyester/porcine collagen group (Fig. 5). There were no deaths in any of the study groups.\nTable 2 Postoperative complications for intraperitoneal implant of polypropylene mesh versus polypropylene with polyglecaprone versus polyester with porcine collagen in rats for correction of abdominal wall defect.\nComplications Post-operative Polypropylene (10 animals) Polypropylene Polyglecaprone (10 animals) Polyester Collagen (10 animals) p-value\nAnimals with complications 4 (40%) 8 (80%) 4 (40%) 0.147\nOperative wound dehiscence 3 (30%) 8 (80%) 4 (40%) 0.122\nUlcer in left thigh 0 3 (30%) 0 0.089\nDifficulty of flexion of the thigh 1 (10%) 0 0 \u003e0.999\nMeshoma 0 1 (10%) 2 (20%) 0.754\nDeath 0 0 0 \u003e0.999\n*Fisher’s exact test (Freeman-Halton) - α = 5% (bilateral)\nFigure 5 Macroscopic aspects of the polyester/porcine collagen mesh after 21 days of intraperitoneal implantation in rats (A and B), and meshoma of the mesh after partial dehiscence of the operative wound (C and D).\nIn relation to the intra-abdominal structures compromised by adhesions with implanted meshes, the epididymal fat, omentum and liver were the most involved in all groups. However, there were no significant differences among the three groups, except for the lower number of adhesions with the liver in the polypropylene/polyglecaprone group (Table 3). The polypropylene mesh group presented a statistically significant greater impairment of the surface of the mesh involved with the visceral adhesions (Fig. 6) from both peripheral sectors (p value=0.005) and from the central sector (p value=0.003) in relation to the polypropylene/polyglecaprone and polyester/porcine collagen groups, which did not present significant differences among themselves (Table 4).\nTable 3 Anatomic structures compromised in the formation of adherences with polypropylene meshes versus polypropylene with polyglecaprone versus polyester with porcine collagen implanted intraperitoneally in rats for correction of abdominal wall defect.\nCompromised anatomical structures Polypropylene (10 animals) Polypropylene Polyglecaprone (10 animals) Polyester Collagen (10 animals) p-value\nEpididymal fat 10 (100%) 9 (90%) 6 (60%) 0.094\nOmentum 10 (100%) 10 (100%) 10 (100%) -\nLiver 10 (100%) 6 (60%) 10 (100%) 0.023\nSmall intestine 0 0 0 -\nCecum 1 (10%) 0 0 \u003e0.999\nBladder 1 (10%) 0 0 \u003e0.999\n*Fisher’s exact test (Freeman-Halton) - α = 5% (bilateral)\nMedian: PP = 8, PP/PG = 5 and PE/CP = 6. Kruskal-Wallis: PP x PP/PG = 0.0030 - PP x PE/CS = 0.0014 – PP/PG x PE/CP = 0.8192\nFigure 6 - Number of mesh sectors compromised by adhesions between abdominal anatomical structures and the visceral face of polypropylene (PP), polypropylene/ polyglecaprone (PP/PG), and polyester/porcine collagen (PE/CP) implanted intraperitoneally in rats.\nTable 4 Location of adhesions in peripheral and central sectors between abdominal anatomical structures and the visceral face of meshes of polypropylene versus polypropylene with polyglecaprone versus polyester with porcine collagen implanted intraperitoneally in rats for correction of abdominal wall defect.\nLocation of adhesions Polypropylene (10 animals) Polypropylene Polyglecaprone (10 animals) Polyester Collagen (10 animals) p-value\nPeripheral 72 (88%) 55 (95%) 52 (96%) *0.005\nCentral 10 (12%) 3 (5%) 3 (4%) **0.003\nTotal 82 (100%) 58 (100%) 55 (100%) *0.002\n*Kruskal-Wallis test - α = 5% (bilateral)\n**Fisher’s exact test - α = 5%(bilateral)\nP-value = 0.005 - Polypropylene versus Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to adhesions in peripheral sectors.\nP-value = 0.003 - Polypropylene versus Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to adhesions in central sectors.\nP-value = 0.002 - Polypropylene versus Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to total adhesions in all peripheral sectors.\nIn relation to the intensity of the adhesions between the intra-abdominal structures and the implanted mesh, the polypropylene mesh group presented a higher degree of statistically significant intense adhesions in relation to the polypropylene/polyglecaprone and polyester/porcine collagen groups (p value\u003c0.001) (Table 5). On the other hand, the polyester/porcine collagen composite group also presented a higher degree of intense adhesions with statistical significance in relation to the polypropylene/polyglecaprone group (p value=0.035), although there was no significant difference in relation to the degree of adherence between both groups (p value=0.289) (Fig. 7).\nTable 5 Degree of adhesions in abdominal anatomical structures and the visceral surface of meshes of polypropylene versus polypropylene with polyglecaprone versus polyester with porcine collagen implanted intraperitoneally in rats for correction of abdominal wall defect.\nDegree of adhesions Polypropylene (10 animals) Polypropylene Poliglecaprone (10 animals) Polyester Collagen (10 animals) p-value\nLittle 1 (1%) 1 (2%) 3 (5%) 0.302\nModerate 4 (5%) 33 (57%) 19 (35%) 0.289\nIntense 77 (94%) 24 (41%) 33 (60%) 0.035\nTotal 82 (100%) 58 (100%) 55 (100%) \u003c 0.001\n*Fisher’s exact test - α = 5%(bilateral)\nP-value \u003c 0.001 - Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to intense adhesions.\nP-value = 0.289 - Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to moderate adhesions.\nP-value = 0.035 - Polypropylene/Polyglecaprone versus Polyester/Porcine Collagen in relation to intense adhesions.\nFigure 7 Aspect of the peritoneal cavity and of the meshes after 21 days of the intraperitoneal implant in rats: (A) without the use of mesh, (B) polypropylene mesh, (C) polypropylene/polyglecaprone mesh and (D) polyester/porcine collagen 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