PMC:6650341 / 4963-5363 JSONTXT

{"project":"2_test","denotations":[{"id":"30723314-22948697-83958248","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"30723314-22948697-83958248","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"30723314-26595812-83958249","span":{"begin":397,"end":399},"obj":"26595812"},{"id":"30723314-26595812-83958249","span":{"begin":397,"end":399},"obj":"26595812"},{"id":"T69580","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"T9800","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"T72436","span":{"begin":397,"end":399},"obj":"26595812"},{"id":"T15486","span":{"begin":397,"end":399},"obj":"26595812"},{"id":"T37928","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"T40469","span":{"begin":99,"end":101},"obj":"22948697"},{"id":"T23281","span":{"begin":397,"end":399},"obj":"26595812"},{"id":"T49194","span":{"begin":397,"end":399},"obj":"26595812"}],"text":"Recent studies in humans have shown that aortic stiffening precedes the development of hypertension24. Mice with smooth muscle overexpression of p22phox, a component of NADPH oxidase, develop renal inflammation, fibrosis, and renal dysfunction, prior to the increase in blood pressure, supporting the notion that arterial stiffening induced by oxidative stress and inflammation causes hypertension25."}