PMC:6650341 / 24071-25490
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6650341","sourcedb":"PMC","sourceid":"6650341","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6650341","text":"Several antioxidant drugs, such as vitamin C, vitamin D, vitamin E, and bardoxolone alone or in combination302–307,310–312,314–317,319,320,324,384,386 with other antioxidants have been shown to prevent the deleterious effects of oxidative stress or hypoxia in different cardiovascular and renal diseases, including hypertension but some with undesirable side effects308,309,318,325,326,327,387,388. A meta-analysis in 135,967 participants in 19 clinical trials showed that high doses of vitamin E increased mortality387. 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