PMC:6640909 / 65607-66440
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6640909","sourcedb":"PMC","sourceid":"6640909","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6640909","text":"7.1 Background\nAt the time of LT-MCS implantation, patients are usually in their mid-50s (EUROMACS: mean 51.7, median 55 years) [91] or older (International Society for Heart and Lung Transplantation Mechanically Assisted Circulatory Support Registry, second report: 72% at \u003e50 years) [92]. The majority of candidates for LT-MCS are INTERMACS level 3 or less, meaning at least they are inotrope dependent. Advanced age and inotrope dependency are both associated with comorbidities. Therefore, a thorough preimplant examination is crucial to identify absolute contraindications for LT-MCS implantation such as surgical contraindications, severe coagulation and haematological disorders and irreversible multiorgan failure. Moreover, life-limiting comorbidities and the chance of improvement after LT-MCS implantation can be assessed.","divisions":[{"label":"title","span":{"begin":0,"end":14}}],"tracks":[{"project":"TEST0","denotations":[{"id":"31100109-114-120-7521","span":{"begin":129,"end":131},"obj":"[\"29029117\"]"},{"id":"31100109-235-241-7522","span":{"begin":286,"end":288},"obj":"[\"29550146\"]"}],"attributes":[{"subj":"31100109-114-120-7521","pred":"source","obj":"TEST0"},{"subj":"31100109-235-241-7522","pred":"source","obj":"TEST0"}]},{"project":"MyTest","denotations":[{"id":"31100109-29029117-28905581","span":{"begin":129,"end":131},"obj":"29029117"},{"id":"31100109-29550146-28905582","span":{"begin":286,"end":288},"obj":"29550146"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31100109-29029117-28905581","pred":"source","obj":"MyTest"},{"subj":"31100109-29550146-28905582","pred":"source","obj":"MyTest"}]},{"project":"0_colil","denotations":[{"id":"31100109-29029117-7521","span":{"begin":129,"end":131},"obj":"29029117"},{"id":"31100109-29550146-7522","span":{"begin":286,"end":288},"obj":"29550146"}],"attributes":[{"subj":"31100109-29029117-7521","pred":"source","obj":"0_colil"},{"subj":"31100109-29550146-7522","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"31100109-29029117-28905581","span":{"begin":129,"end":131},"obj":"29029117"},{"id":"31100109-29550146-28905582","span":{"begin":286,"end":288},"obj":"29550146"}],"attributes":[{"subj":"31100109-29029117-28905581","pred":"source","obj":"2_test"},{"subj":"31100109-29550146-28905582","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93b7ec","default":true},{"id":"MyTest","color":"#d1ec93"},{"id":"0_colil","color":"#ec93eb"},{"id":"2_test","color":"#93ecd3"}]}]}}