PMC:6640909 / 17944-21460 JSONTXT

{"project":"TEST0","denotations":[{"id":"31100109-236-243-7191","span":{"begin":379,"end":382},"obj":"[\"20615720\"]"},{"id":"31100109-236-243-7192","span":{"begin":560,"end":563},"obj":"[\"20850652\"]"},{"id":"31100109-10-17-7193","span":{"begin":565,"end":568},"obj":"[\"15691674\"]"},{"id":"31100109-15-22-7194","span":{"begin":570,"end":573},"obj":"[\"17320566\"]"},{"id":"31100109-20-27-7195","span":{"begin":575,"end":578},"obj":"[\"21354812\"]"},{"id":"31100109-222-228-7196","span":{"begin":793,"end":795},"obj":"[\"24486165\"]"},{"id":"31100109-9-15-7197","span":{"begin":797,"end":799},"obj":"[\"28843393\"]"},{"id":"31100109-226-232-7198","span":{"begin":958,"end":960},"obj":"[\"20123242\"]"},{"id":"31100109-9-15-7199","span":{"begin":962,"end":964},"obj":"[\"24119728\"]"},{"id":"31100109-13-19-7200","span":{"begin":966,"end":968},"obj":"[\"23352391\"]"},{"id":"31100109-17-24-7201","span":{"begin":970,"end":973},"obj":"[\"23065497\"]"},{"id":"31100109-229-235-7202","span":{"begin":1098,"end":1100},"obj":"[\"20123242\"]"},{"id":"31100109-9-15-7203","span":{"begin":1102,"end":1104},"obj":"[\"24119728\"]"},{"id":"31100109-13-20-7204","span":{"begin":1106,"end":1109},"obj":"[\"23065497\"]"},{"id":"31100109-227-234-7205","span":{"begin":1335,"end":1338},"obj":"[\"26169667\"]"},{"id":"31100109-8-15-7206","span":{"begin":1340,"end":1343},"obj":"[\"25925372\"]"},{"id":"31100109-220-227-7207","span":{"begin":1709,"end":1712},"obj":"[\"26169667\"]"},{"id":"31100109-228-235-7208","span":{"begin":1849,"end":1852},"obj":"[\"28624338\"]"},{"id":"31100109-230-236-7209","span":{"begin":2074,"end":2076},"obj":"[\"28942782\"]"},{"id":"31100109-235-242-7210","span":{"begin":2280,"end":2283},"obj":"[\"25085498\"]"},{"id":"31100109-232-239-7211","span":{"begin":2423,"end":2426},"obj":"[\"17720387\"]"},{"id":"31100109-229-235-7212","span":{"begin":2529,"end":2531},"obj":"[\"26520247\"]"},{"id":"31100109-9-15-7213","span":{"begin":2533,"end":2535},"obj":"[\"20123242\"]"},{"id":"31100109-13-20-7214","span":{"begin":2537,"end":2540},"obj":"[\"19384093\"]"},{"id":"31100109-234-240-7215","span":{"begin":2651,"end":2653},"obj":"[\"26520247\"]"},{"id":"31100109-9-15-7216","span":{"begin":2655,"end":2657},"obj":"[\"20123242\"]"},{"id":"31100109-13-20-7217","span":{"begin":2659,"end":2662},"obj":"[\"19384093\"]"},{"id":"31100109-10-17-7218","span":{"begin":3234,"end":3237},"obj":"[\"20598466\"]"},{"id":"31100109-131-138-7219","span":{"begin":3507,"end":3510},"obj":"[\"27003430\"]"},{"id":"31100109-136-143-7220","span":{"begin":3512,"end":3515},"obj":"[\"28633256\"]"}],"text":"Recommendation Class Level References\nMalignancies\nEvaluation for malignancies is recommended. I A\nIn patients with a proven malignancy and an expected survival of \u003c1 year, implantation of long-term mechanical circulatory support is not recommended. III C\nPulmonary hypertension\nInvasive haemodynamic assessment of pulmonary vascular resistance is recommended. I C [107]\nIn heart transplant candidates, normalization of elevated pulmonary vascular resistance in patients on long-term mechanical circulatory support should be considered. IIa B [108, 109, 130, 131]\nCardiac cachexia\nAssessment of frailty and nutritional status using a frailty score and/or prognostic nutrition index prior to implantation of long-term mechanical circulatory support may be considered. IIb C [48, 96]\nRenal dysfunction\nImplantation of long-term mechanical circulatory support should be considered in case of reversible secondary renal dysfunction. IIa C [37, 56, 71, 103]\nImplantation of long-term mechanical circulatory support may be considered in patients on chronic haemodialysis. IIb C [37, 56, 103]\nNeurological function and disorders\nCareful neurological examination is recommended for all candidates for implantation of long-term mechanical circulatory support including assessment of dementia and mental status. I C [104, 132]\nMultidisciplinary evaluation of prognosis of survival and morbidity of patients with neuromuscular disorders is recommended. I C [133]\nAdherence (medical therapy, alcohol, tobacco, psychological, psychiatric and social derangement)\nScreening for psychological and psychiatric (including cognitive function) disorders and substance abuse is recommended. I C [104]\nIt is recommended that adherence (tobacco, alcohol and substance abuse), psychosocial risks and familial support be evaluated. I C [134]\nIn patients with frailty, psychiatric or neurological disorders, evaluation of their ability to operate the device is recommended. I C\nVascular disease\nScreening for peripheral vascular disease is recommended. I C [67]\nCoagulation and haematological disorders\nEvaluation of all long-term mechanical circulatory support candidates for coagulopathies and hypercoagulable states (e.g. thrombophilia) is recommended. I C [135]\nIn patients with thrombocytopenia after exposure to heparin, testing for heparin-induced thrombocytopenia should be considered. IIa C [136]\nRespiratory considerations\nSpirometry as part of the patient work-up should be considered. IIa C [25, 37, 137]\nPreoperative thoracic imaging should be considered as part of the overall risk/benefit evaluation. IIa C [25, 37, 137]\nDiabetes\nScreening for diabetes mellitus (including end-organ damage) before implant of long-term mechanical circulatory support is recommended. For patients with poorly controlled diabetes, consultation with a diabetologist is recommended. I C\nImplantation of long-term mechanical circulatory support in patients with diabetes with severe end-organ complications is not recommended. III C\nGastrointestinal disorders\nGastrointestinal bleeding in patients 50 years or older: faecal occult blood testing, gastroscopy and endoscopy should be considered. IIa C [116, 117]\nPregnancy\nContraception in women of childbearing age after implant of long-term mechanical circulatory support is recommended. I C\nLong-term mechanical circulatory support in the setting of pregnancy is a multidisciplinary challenge and may be considered. IIb C [128, 129]"}

{"project":"MyTest","denotations":[{"id":"31100109-20615720-28905251","span":{"begin":379,"end":382},"obj":"20615720"},{"id":"31100109-20850652-28905252","span":{"begin":560,"end":563},"obj":"20850652"},{"id":"31100109-15691674-28905253","span":{"begin":565,"end":568},"obj":"15691674"},{"id":"31100109-17320566-28905254","span":{"begin":570,"end":573},"obj":"17320566"},{"id":"31100109-21354812-28905255","span":{"begin":575,"end":578},"obj":"21354812"},{"id":"31100109-24486165-28905256","span":{"begin":793,"end":795},"obj":"24486165"},{"id":"31100109-28843393-28905257","span":{"begin":797,"end":799},"obj":"28843393"},{"id":"31100109-20123242-28905258","span":{"begin":958,"end":960},"obj":"20123242"},{"id":"31100109-24119728-28905259","span":{"begin":962,"end":964},"obj":"24119728"},{"id":"31100109-23352391-28905260","span":{"begin":966,"end":968},"obj":"23352391"},{"id":"31100109-23065497-28905261","span":{"begin":970,"end":973},"obj":"23065497"},{"id":"31100109-20123242-28905262","span":{"begin":1098,"end":1100},"obj":"20123242"},{"id":"31100109-24119728-28905263","span":{"begin":1102,"end":1104},"obj":"24119728"},{"id":"31100109-23065497-28905264","span":{"begin":1106,"end":1109},"obj":"23065497"},{"id":"31100109-26169667-28905265","span":{"begin":1335,"end":1338},"obj":"26169667"},{"id":"31100109-25925372-28905266","span":{"begin":1340,"end":1343},"obj":"25925372"},{"id":"31100109-26169667-28905267","span":{"begin":1709,"end":1712},"obj":"26169667"},{"id":"31100109-28624338-28905268","span":{"begin":1849,"end":1852},"obj":"28624338"},{"id":"31100109-28942782-28905269","span":{"begin":2074,"end":2076},"obj":"28942782"},{"id":"31100109-25085498-28905270","span":{"begin":2280,"end":2283},"obj":"25085498"},{"id":"31100109-17720387-28905271","span":{"begin":2423,"end":2426},"obj":"17720387"},{"id":"31100109-26520247-28905272","span":{"begin":2529,"end":2531},"obj":"26520247"},{"id":"31100109-20123242-28905273","span":{"begin":2533,"end":2535},"obj":"20123242"},{"id":"31100109-19384093-28905274","span":{"begin":2537,"end":2540},"obj":"19384093"},{"id":"31100109-26520247-28905275","span":{"begin":2651,"end":2653},"obj":"26520247"},{"id":"31100109-20123242-28905276","span":{"begin":2655,"end":2657},"obj":"20123242"},{"id":"31100109-19384093-28905277","span":{"begin":2659,"end":2662},"obj":"19384093"},{"id":"31100109-20598466-28905278","span":{"begin":3234,"end":3237},"obj":"20598466"},{"id":"31100109-27003430-28905279","span":{"begin":3507,"end":3510},"obj":"27003430"},{"id":"31100109-28633256-28905280","span":{"begin":3512,"end":3515},"obj":"28633256"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Recommendation Class Level References\nMalignancies\nEvaluation for malignancies is recommended. I A\nIn patients with a proven malignancy and an expected survival of \u003c1 year, implantation of long-term mechanical circulatory support is not recommended. III C\nPulmonary hypertension\nInvasive haemodynamic assessment of pulmonary vascular resistance is recommended. I C [107]\nIn heart transplant candidates, normalization of elevated pulmonary vascular resistance in patients on long-term mechanical circulatory support should be considered. IIa B [108, 109, 130, 131]\nCardiac cachexia\nAssessment of frailty and nutritional status using a frailty score and/or prognostic nutrition index prior to implantation of long-term mechanical circulatory support may be considered. IIb C [48, 96]\nRenal dysfunction\nImplantation of long-term mechanical circulatory support should be considered in case of reversible secondary renal dysfunction. IIa C [37, 56, 71, 103]\nImplantation of long-term mechanical circulatory support may be considered in patients on chronic haemodialysis. IIb C [37, 56, 103]\nNeurological function and disorders\nCareful neurological examination is recommended for all candidates for implantation of long-term mechanical circulatory support including assessment of dementia and mental status. I C [104, 132]\nMultidisciplinary evaluation of prognosis of survival and morbidity of patients with neuromuscular disorders is recommended. I C [133]\nAdherence (medical therapy, alcohol, tobacco, psychological, psychiatric and social derangement)\nScreening for psychological and psychiatric (including cognitive function) disorders and substance abuse is recommended. I C [104]\nIt is recommended that adherence (tobacco, alcohol and substance abuse), psychosocial risks and familial support be evaluated. I C [134]\nIn patients with frailty, psychiatric or neurological disorders, evaluation of their ability to operate the device is recommended. I C\nVascular disease\nScreening for peripheral vascular disease is recommended. I C [67]\nCoagulation and haematological disorders\nEvaluation of all long-term mechanical circulatory support candidates for coagulopathies and hypercoagulable states (e.g. thrombophilia) is recommended. I C [135]\nIn patients with thrombocytopenia after exposure to heparin, testing for heparin-induced thrombocytopenia should be considered. IIa C [136]\nRespiratory considerations\nSpirometry as part of the patient work-up should be considered. IIa C [25, 37, 137]\nPreoperative thoracic imaging should be considered as part of the overall risk/benefit evaluation. IIa C [25, 37, 137]\nDiabetes\nScreening for diabetes mellitus (including end-organ damage) before implant of long-term mechanical circulatory support is recommended. For patients with poorly controlled diabetes, consultation with a diabetologist is recommended. I C\nImplantation of long-term mechanical circulatory support in patients with diabetes with severe end-organ complications is not recommended. III C\nGastrointestinal disorders\nGastrointestinal bleeding in patients 50 years or older: faecal occult blood testing, gastroscopy and endoscopy should be considered. IIa C [116, 117]\nPregnancy\nContraception in women of childbearing age after implant of long-term mechanical circulatory support is recommended. I C\nLong-term mechanical circulatory support in the setting of pregnancy is a multidisciplinary challenge and may be considered. IIb C [128, 129]"}

{"project":"0_colil","denotations":[{"id":"31100109-20615720-7191","span":{"begin":379,"end":382},"obj":"20615720"},{"id":"31100109-20850652-7192","span":{"begin":560,"end":563},"obj":"20850652"},{"id":"31100109-15691674-7193","span":{"begin":565,"end":568},"obj":"15691674"},{"id":"31100109-17320566-7194","span":{"begin":570,"end":573},"obj":"17320566"},{"id":"31100109-21354812-7195","span":{"begin":575,"end":578},"obj":"21354812"},{"id":"31100109-24486165-7196","span":{"begin":793,"end":795},"obj":"24486165"},{"id":"31100109-28843393-7197","span":{"begin":797,"end":799},"obj":"28843393"},{"id":"31100109-20123242-7198","span":{"begin":958,"end":960},"obj":"20123242"},{"id":"31100109-24119728-7199","span":{"begin":962,"end":964},"obj":"24119728"},{"id":"31100109-23352391-7200","span":{"begin":966,"end":968},"obj":"23352391"},{"id":"31100109-23065497-7201","span":{"begin":970,"end":973},"obj":"23065497"},{"id":"31100109-20123242-7202","span":{"begin":1098,"end":1100},"obj":"20123242"},{"id":"31100109-24119728-7203","span":{"begin":1102,"end":1104},"obj":"24119728"},{"id":"31100109-23065497-7204","span":{"begin":1106,"end":1109},"obj":"23065497"},{"id":"31100109-26169667-7205","span":{"begin":1335,"end":1338},"obj":"26169667"},{"id":"31100109-25925372-7206","span":{"begin":1340,"end":1343},"obj":"25925372"},{"id":"31100109-26169667-7207","span":{"begin":1709,"end":1712},"obj":"26169667"},{"id":"31100109-28624338-7208","span":{"begin":1849,"end":1852},"obj":"28624338"},{"id":"31100109-28942782-7209","span":{"begin":2074,"end":2076},"obj":"28942782"},{"id":"31100109-25085498-7210","span":{"begin":2280,"end":2283},"obj":"25085498"},{"id":"31100109-17720387-7211","span":{"begin":2423,"end":2426},"obj":"17720387"},{"id":"31100109-26520247-7212","span":{"begin":2529,"end":2531},"obj":"26520247"},{"id":"31100109-20123242-7213","span":{"begin":2533,"end":2535},"obj":"20123242"},{"id":"31100109-19384093-7214","span":{"begin":2537,"end":2540},"obj":"19384093"},{"id":"31100109-26520247-7215","span":{"begin":2651,"end":2653},"obj":"26520247"},{"id":"31100109-20123242-7216","span":{"begin":2655,"end":2657},"obj":"20123242"},{"id":"31100109-19384093-7217","span":{"begin":2659,"end":2662},"obj":"19384093"},{"id":"31100109-20598466-7218","span":{"begin":3234,"end":3237},"obj":"20598466"},{"id":"31100109-27003430-7219","span":{"begin":3507,"end":3510},"obj":"27003430"},{"id":"31100109-28633256-7220","span":{"begin":3512,"end":3515},"obj":"28633256"}],"text":"Recommendation Class Level References\nMalignancies\nEvaluation for malignancies is recommended. I A\nIn patients with a proven malignancy and an expected survival of \u003c1 year, implantation of long-term mechanical circulatory support is not recommended. III C\nPulmonary hypertension\nInvasive haemodynamic assessment of pulmonary vascular resistance is recommended. I C [107]\nIn heart transplant candidates, normalization of elevated pulmonary vascular resistance in patients on long-term mechanical circulatory support should be considered. IIa B [108, 109, 130, 131]\nCardiac cachexia\nAssessment of frailty and nutritional status using a frailty score and/or prognostic nutrition index prior to implantation of long-term mechanical circulatory support may be considered. IIb C [48, 96]\nRenal dysfunction\nImplantation of long-term mechanical circulatory support should be considered in case of reversible secondary renal dysfunction. IIa C [37, 56, 71, 103]\nImplantation of long-term mechanical circulatory support may be considered in patients on chronic haemodialysis. IIb C [37, 56, 103]\nNeurological function and disorders\nCareful neurological examination is recommended for all candidates for implantation of long-term mechanical circulatory support including assessment of dementia and mental status. I C [104, 132]\nMultidisciplinary evaluation of prognosis of survival and morbidity of patients with neuromuscular disorders is recommended. I C [133]\nAdherence (medical therapy, alcohol, tobacco, psychological, psychiatric and social derangement)\nScreening for psychological and psychiatric (including cognitive function) disorders and substance abuse is recommended. I C [104]\nIt is recommended that adherence (tobacco, alcohol and substance abuse), psychosocial risks and familial support be evaluated. I C [134]\nIn patients with frailty, psychiatric or neurological disorders, evaluation of their ability to operate the device is recommended. I C\nVascular disease\nScreening for peripheral vascular disease is recommended. I C [67]\nCoagulation and haematological disorders\nEvaluation of all long-term mechanical circulatory support candidates for coagulopathies and hypercoagulable states (e.g. thrombophilia) is recommended. I C [135]\nIn patients with thrombocytopenia after exposure to heparin, testing for heparin-induced thrombocytopenia should be considered. IIa C [136]\nRespiratory considerations\nSpirometry as part of the patient work-up should be considered. IIa C [25, 37, 137]\nPreoperative thoracic imaging should be considered as part of the overall risk/benefit evaluation. IIa C [25, 37, 137]\nDiabetes\nScreening for diabetes mellitus (including end-organ damage) before implant of long-term mechanical circulatory support is recommended. For patients with poorly controlled diabetes, consultation with a diabetologist is recommended. I C\nImplantation of long-term mechanical circulatory support in patients with diabetes with severe end-organ complications is not recommended. III C\nGastrointestinal disorders\nGastrointestinal bleeding in patients 50 years or older: faecal occult blood testing, gastroscopy and endoscopy should be considered. IIa C [116, 117]\nPregnancy\nContraception in women of childbearing age after implant of long-term mechanical circulatory support is recommended. I C\nLong-term mechanical circulatory support in the setting of pregnancy is a multidisciplinary challenge and may be considered. IIb C [128, 129]"}

{"project":"2_test","denotations":[{"id":"31100109-20615720-28905251","span":{"begin":379,"end":382},"obj":"20615720"},{"id":"31100109-20850652-28905252","span":{"begin":560,"end":563},"obj":"20850652"},{"id":"31100109-15691674-28905253","span":{"begin":565,"end":568},"obj":"15691674"},{"id":"31100109-17320566-28905254","span":{"begin":570,"end":573},"obj":"17320566"},{"id":"31100109-21354812-28905255","span":{"begin":575,"end":578},"obj":"21354812"},{"id":"31100109-24486165-28905256","span":{"begin":793,"end":795},"obj":"24486165"},{"id":"31100109-28843393-28905257","span":{"begin":797,"end":799},"obj":"28843393"},{"id":"31100109-20123242-28905258","span":{"begin":958,"end":960},"obj":"20123242"},{"id":"31100109-24119728-28905259","span":{"begin":962,"end":964},"obj":"24119728"},{"id":"31100109-23352391-28905260","span":{"begin":966,"end":968},"obj":"23352391"},{"id":"31100109-23065497-28905261","span":{"begin":970,"end":973},"obj":"23065497"},{"id":"31100109-20123242-28905262","span":{"begin":1098,"end":1100},"obj":"20123242"},{"id":"31100109-24119728-28905263","span":{"begin":1102,"end":1104},"obj":"24119728"},{"id":"31100109-23065497-28905264","span":{"begin":1106,"end":1109},"obj":"23065497"},{"id":"31100109-26169667-28905265","span":{"begin":1335,"end":1338},"obj":"26169667"},{"id":"31100109-25925372-28905266","span":{"begin":1340,"end":1343},"obj":"25925372"},{"id":"31100109-26169667-28905267","span":{"begin":1709,"end":1712},"obj":"26169667"},{"id":"31100109-28624338-28905268","span":{"begin":1849,"end":1852},"obj":"28624338"},{"id":"31100109-28942782-28905269","span":{"begin":2074,"end":2076},"obj":"28942782"},{"id":"31100109-25085498-28905270","span":{"begin":2280,"end":2283},"obj":"25085498"},{"id":"31100109-17720387-28905271","span":{"begin":2423,"end":2426},"obj":"17720387"},{"id":"31100109-26520247-28905272","span":{"begin":2529,"end":2531},"obj":"26520247"},{"id":"31100109-20123242-28905273","span":{"begin":2533,"end":2535},"obj":"20123242"},{"id":"31100109-19384093-28905274","span":{"begin":2537,"end":2540},"obj":"19384093"},{"id":"31100109-26520247-28905275","span":{"begin":2651,"end":2653},"obj":"26520247"},{"id":"31100109-20123242-28905276","span":{"begin":2655,"end":2657},"obj":"20123242"},{"id":"31100109-19384093-28905277","span":{"begin":2659,"end":2662},"obj":"19384093"},{"id":"31100109-20598466-28905278","span":{"begin":3234,"end":3237},"obj":"20598466"},{"id":"31100109-27003430-28905279","span":{"begin":3507,"end":3510},"obj":"27003430"},{"id":"31100109-28633256-28905280","span":{"begin":3512,"end":3515},"obj":"28633256"}],"text":"Recommendation Class Level References\nMalignancies\nEvaluation for malignancies is recommended. I A\nIn patients with a proven malignancy and an expected survival of \u003c1 year, implantation of long-term mechanical circulatory support is not recommended. III C\nPulmonary hypertension\nInvasive haemodynamic assessment of pulmonary vascular resistance is recommended. I C [107]\nIn heart transplant candidates, normalization of elevated pulmonary vascular resistance in patients on long-term mechanical circulatory support should be considered. IIa B [108, 109, 130, 131]\nCardiac cachexia\nAssessment of frailty and nutritional status using a frailty score and/or prognostic nutrition index prior to implantation of long-term mechanical circulatory support may be considered. IIb C [48, 96]\nRenal dysfunction\nImplantation of long-term mechanical circulatory support should be considered in case of reversible secondary renal dysfunction. IIa C [37, 56, 71, 103]\nImplantation of long-term mechanical circulatory support may be considered in patients on chronic haemodialysis. IIb C [37, 56, 103]\nNeurological function and disorders\nCareful neurological examination is recommended for all candidates for implantation of long-term mechanical circulatory support including assessment of dementia and mental status. I C [104, 132]\nMultidisciplinary evaluation of prognosis of survival and morbidity of patients with neuromuscular disorders is recommended. I C [133]\nAdherence (medical therapy, alcohol, tobacco, psychological, psychiatric and social derangement)\nScreening for psychological and psychiatric (including cognitive function) disorders and substance abuse is recommended. I C [104]\nIt is recommended that adherence (tobacco, alcohol and substance abuse), psychosocial risks and familial support be evaluated. I C [134]\nIn patients with frailty, psychiatric or neurological disorders, evaluation of their ability to operate the device is recommended. I C\nVascular disease\nScreening for peripheral vascular disease is recommended. I C [67]\nCoagulation and haematological disorders\nEvaluation of all long-term mechanical circulatory support candidates for coagulopathies and hypercoagulable states (e.g. thrombophilia) is recommended. I C [135]\nIn patients with thrombocytopenia after exposure to heparin, testing for heparin-induced thrombocytopenia should be considered. IIa C [136]\nRespiratory considerations\nSpirometry as part of the patient work-up should be considered. IIa C [25, 37, 137]\nPreoperative thoracic imaging should be considered as part of the overall risk/benefit evaluation. IIa C [25, 37, 137]\nDiabetes\nScreening for diabetes mellitus (including end-organ damage) before implant of long-term mechanical circulatory support is recommended. For patients with poorly controlled diabetes, consultation with a diabetologist is recommended. I C\nImplantation of long-term mechanical circulatory support in patients with diabetes with severe end-organ complications is not recommended. III C\nGastrointestinal disorders\nGastrointestinal bleeding in patients 50 years or older: faecal occult blood testing, gastroscopy and endoscopy should be considered. IIa C [116, 117]\nPregnancy\nContraception in women of childbearing age after implant of long-term mechanical circulatory support is recommended. I C\nLong-term mechanical circulatory support in the setting of pregnancy is a multidisciplinary challenge and may be considered. IIb C [128, 129]"}