PMC:6636912 / 11421-12801 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6636912","sourcedb":"PMC","sourceid":"6636912","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6636912","text":"What is the best clinic treatment strategy and option? All patients with KPDM should be treated according to established principles of acute management of metabolic decompensation. Insulin replacement therapy is necessary at the acute state of insulin deficient and hyperglycemia crisis. Lifestyle changes, including optimal diet, weight loss, exercise and smoking cessation, are an important part of the treatment regimen to prevent obesity and improve insulin sensitivity, as well as to maintain good glycemic control.[20,21] Screening and treatment for microvascular and macrovascular complications of diabetes should be advised according to American Diabetes Association (ADA) recommendation and long term management guidelines.[22] In summary, the description is of a case of ketosis prone diabetes in an obese young Chinese teenager, who displayed uncommon clinic presentation and findings typical of both type 1 and type 2 diabetes. However, after initial insulinization near-normoglycaemic control and restoration of normotriglycemia rapidly lead to improvement in beta-cell function. The patient was able to come off insulin therapy without relapse of ketoacidosis as previous reported. His unprovoked DKA, negative auto-antibodies and partially preserved beta cell functional reserve after the acute of diabetic ketosis suggested that he has the phenotype of “A–β+” KPD.","tracks":[{"project":"2_test","denotations":[{"id":"31232947-28668376-68672942","span":{"begin":521,"end":523},"obj":"28668376"},{"id":"31232947-26210987-68672943","span":{"begin":524,"end":526},"obj":"26210987"},{"id":"31232947-29490093-68672944","span":{"begin":733,"end":735},"obj":"29490093"}],"attributes":[{"subj":"31232947-28668376-68672942","pred":"source","obj":"2_test"},{"subj":"31232947-26210987-68672943","pred":"source","obj":"2_test"},{"subj":"31232947-29490093-68672944","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d293ec","default":true}]}]}}