PMC:6610391 / 863-1694 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610391","sourcedb":"PMC","sourceid":"6610391","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610391","text":"Results:\nNormal development occurred in only 15% of IS of unknown cause. The majority (85%) had clinically documented developmental delay (15% mild, 20% moderate, and 50% severe) at last assessment (median 2.7 years; interquartile interval 1.71-6.25 years). Predictors of positive developmental outcomes included no delay prior to IS (P \u003c .001), older age of IS onset (median 6 months old), and resolution of IS after initial treatment (P \u003c .001). Additional seizures after IS occurred in 67%, with predictors being seizures prior to IS (P = .018), earlier age of IS onset (median 5 months old), and refractory IS (P = .008). On a research basis, whole exome sequencing identified 15% with de novo variants in known epilepsy genes. Individuals with a genetic finding were more likely to have poor developmental outcomes (P = .035).","divisions":[{"label":"title","span":{"begin":0,"end":8}}],"tracks":[]}