PMC:6610391 / 3672-4573
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610391","sourcedb":"PMC","sourceid":"6610391","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610391","text":"Although specific underlying etiologies do not appear to predict outcome in IS, the presence or absence of identifiable etiology does. Meta-analysis demonstrated overall good developmental outcome in 54.3% in patients with IS of unknown etiology but only 12.5% in IS patients with identifiable etiology.4 Seizure relapse, including epileptic spasms, has been reported to occur more often in those with known etiology.5 A retrospective review of 71 infants with IS demonstrated that seizure relapse was common (66% overall), but much less so in unknown (29%) than known (75%) etiology.5 Furthermore, infants with no identified etiology treated with hormonal treatment may have improved development compared to those treated with vigabatrin.6 It is now recommended that hormonal therapy be considered preferentially over vigabatrin for treatment of IS of unknown cause to improve developmental outcome.7","tracks":[{"project":"MyTest","denotations":[{"id":"31062601-25524855-28638751","span":{"begin":303,"end":305},"obj":"25524855"},{"id":"31062601-24939523-28638752","span":{"begin":417,"end":419},"obj":"24939523"},{"id":"31062601-24939523-28638753","span":{"begin":584,"end":586},"obj":"24939523"},{"id":"31062601-21668442-28638754","span":{"begin":739,"end":741},"obj":"21668442"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31062601-25524855-28638751","pred":"source","obj":"MyTest"},{"subj":"31062601-24939523-28638752","pred":"source","obj":"MyTest"},{"subj":"31062601-24939523-28638753","pred":"source","obj":"MyTest"},{"subj":"31062601-21668442-28638754","pred":"source","obj":"MyTest"}]},{"project":"0_colil","denotations":[{"id":"31062601-25524855-484","span":{"begin":303,"end":304},"obj":"25524855"},{"id":"31062601-24939523-485","span":{"begin":417,"end":418},"obj":"24939523"},{"id":"31062601-24939523-486","span":{"begin":584,"end":585},"obj":"24939523"},{"id":"31062601-21668442-487","span":{"begin":739,"end":740},"obj":"21668442"},{"id":"31062601-22689735-488","span":{"begin":900,"end":901},"obj":"22689735"}],"attributes":[{"subj":"31062601-25524855-484","pred":"source","obj":"0_colil"},{"subj":"31062601-24939523-485","pred":"source","obj":"0_colil"},{"subj":"31062601-24939523-486","pred":"source","obj":"0_colil"},{"subj":"31062601-21668442-487","pred":"source","obj":"0_colil"},{"subj":"31062601-22689735-488","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"31062601-25524855-28638751","span":{"begin":303,"end":304},"obj":"25524855"},{"id":"31062601-24939523-28638752","span":{"begin":417,"end":418},"obj":"24939523"},{"id":"31062601-24939523-28638753","span":{"begin":584,"end":585},"obj":"24939523"},{"id":"31062601-21668442-28638754","span":{"begin":739,"end":740},"obj":"21668442"},{"id":"31062601-22689735-28638755","span":{"begin":900,"end":901},"obj":"22689735"}],"attributes":[{"subj":"31062601-25524855-28638751","pred":"source","obj":"2_test"},{"subj":"31062601-24939523-28638752","pred":"source","obj":"2_test"},{"subj":"31062601-24939523-28638753","pred":"source","obj":"2_test"},{"subj":"31062601-21668442-28638754","pred":"source","obj":"2_test"},{"subj":"31062601-22689735-28638755","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93e2ec","default":true},{"id":"0_colil","color":"#ecdb93"},{"id":"2_test","color":"#c193ec"}]}]}}