PMC:6610326 / 98008-98704 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-28235672-38515929","span":{"begin":228,"end":232},"obj":"28235672"},{"id":"31316328-30721407-38515931","span":{"begin":460,"end":464},"obj":"30721407"}],"text":"Efficient intracellular trafficking is required to maintain the structure and function of MNs, particularly because MNs have very long axons that connect the soma with distant synaptic sites [reviewed in De Vos and Hafezparast (2017)]. Disorganization of the neuronal cytoskeleton and inhibition of axonal, ER-Golgi, endosomal and nucleocytoplasmic transport, are now widely reported features of ALS [reviewed in Parakh et al. (2018b) and Burk and Pasterkamp (2019)]. Importantly, defects in trafficking could reduce the supply of components necessary for synaptic and/or somal function, and prevent clearance of waste products from the synapse, together contributing to neurodegeneration in ALS."}

{"project":"0_colil","denotations":[{"id":"31316328-28235672-631386","span":{"begin":228,"end":232},"obj":"28235672"},{"id":"31316328-30721407-631388","span":{"begin":460,"end":464},"obj":"30721407"}],"text":"Efficient intracellular trafficking is required to maintain the structure and function of MNs, particularly because MNs have very long axons that connect the soma with distant synaptic sites [reviewed in De Vos and Hafezparast (2017)]. Disorganization of the neuronal cytoskeleton and inhibition of axonal, ER-Golgi, endosomal and nucleocytoplasmic transport, are now widely reported features of ALS [reviewed in Parakh et al. (2018b) and Burk and Pasterkamp (2019)]. Importantly, defects in trafficking could reduce the supply of components necessary for synaptic and/or somal function, and prevent clearance of waste products from the synapse, together contributing to neurodegeneration in ALS."}