PMC:6610326 / 95068-96200 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-13495469-38515907","span":{"begin":513,"end":517},"obj":"13495469"},{"id":"31316328-25088365-38515908","span":{"begin":537,"end":541},"obj":"25088365"},{"id":"31316328-25107988-38515909","span":{"begin":647,"end":651},"obj":"25107988"},{"id":"31316328-29502344-38515910","span":{"begin":1005,"end":1009},"obj":"29502344"}],"text":"Motor Neuron Size\nMotor neurons can vary widely in their size and this can impact on their physiological functions. There is also increasing evidence that vulnerability to degeneration is related to MN size. The disease-vulnerable FF-MNs somas are larger than the S-MN resistant types, and they possess larger motor units. Moreover, the size of a MN also correlates inversely with its excitability, discharge behavior, firing rate, recruitment during movement, and vulnerability to degeneration in ALS (Henneman, 1957; Le Masson et al., 2014). The soma of MNs from male SOD1G93A mice is larger than those of wild type male mice (Shoenfeld et al., 2014). Furthermore, a recent study demonstrated that not only are the larger MN subtypes more vulnerable to neurodegeneration in SOD1G93A mice, but MNs also increase in size during disease in multiple regions of the spinal cord. Interestingly, in silico modeling predicted that the excitability properties of these cells were also altered (Dukkipati et al., 2018). Hence, MN size may alter during disease progression, and this plasticity may impact on the vulnerability of MN subtypes."}

{"project":"0_colil","denotations":[{"id":"31316328-13495469-631364","span":{"begin":513,"end":517},"obj":"13495469"},{"id":"31316328-25088365-631365","span":{"begin":537,"end":541},"obj":"25088365"},{"id":"31316328-25107988-631366","span":{"begin":647,"end":651},"obj":"25107988"},{"id":"31316328-29502344-631367","span":{"begin":1005,"end":1009},"obj":"29502344"}],"text":"Motor Neuron Size\nMotor neurons can vary widely in their size and this can impact on their physiological functions. There is also increasing evidence that vulnerability to degeneration is related to MN size. The disease-vulnerable FF-MNs somas are larger than the S-MN resistant types, and they possess larger motor units. Moreover, the size of a MN also correlates inversely with its excitability, discharge behavior, firing rate, recruitment during movement, and vulnerability to degeneration in ALS (Henneman, 1957; Le Masson et al., 2014). The soma of MNs from male SOD1G93A mice is larger than those of wild type male mice (Shoenfeld et al., 2014). Furthermore, a recent study demonstrated that not only are the larger MN subtypes more vulnerable to neurodegeneration in SOD1G93A mice, but MNs also increase in size during disease in multiple regions of the spinal cord. Interestingly, in silico modeling predicted that the excitability properties of these cells were also altered (Dukkipati et al., 2018). Hence, MN size may alter during disease progression, and this plasticity may impact on the vulnerability of MN subtypes."}