PMC:6610326 / 72642-73732
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610326","sourcedb":"PMC","sourceid":"6610326","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610326","text":"Matrix Metalloproteinase (MMP9) has been recently identified as another determinant of selective neuronal vulnerability in SOD1G93A mice (Kaplan et al., 2014). MMP-9 was strongly expressed by vulnerable FR spinal MNs, but not oculomotor, Onuf’s nuclei or S α-MNs, and it enhanced ER stress and mediated muscle denervation in this model (Kaplan et al., 2014). Delivery of MMP-9 into FF-MNs, but not in oculomotor neurons, accelerates denervation in SOD1G93A mice (Kaplan et al., 2014). Similarly, another study demonstrated that reduction of MMP-9 expression attenuated neuromuscular defects in rNLS8 mice expressing cytoplasmic hTDP43ΔNLS in neurons (Spiller et al., 2019). Edaravone, a free radical scavenger which inhibits MMP-9 expression, was recently approved for the treatment of ALS in Japan, South Korea, United States and Canada (Yoshino and Kimura, 2006; Ito et al., 2008; Yagi et al., 2009). Further molecular investigations into the differences and similarities between different motor units in ALS should yield additional insights into their vulnerability to neurodegeneration.","tracks":[{"project":"2_test","denotations":[{"id":"31316328-24462097-38515753","span":{"begin":153,"end":157},"obj":"24462097"},{"id":"31316328-24462097-38515754","span":{"begin":352,"end":356},"obj":"24462097"},{"id":"31316328-24462097-38515755","span":{"begin":478,"end":482},"obj":"24462097"},{"id":"31316328-30458231-38515756","span":{"begin":667,"end":671},"obj":"30458231"},{"id":"31316328-17127563-38515757","span":{"begin":859,"end":863},"obj":"17127563"},{"id":"31316328-18718468-38515758","span":{"begin":877,"end":881},"obj":"18718468"},{"id":"31316328-19095969-38515759","span":{"begin":896,"end":900},"obj":"19095969"}],"attributes":[{"subj":"31316328-24462097-38515753","pred":"source","obj":"2_test"},{"subj":"31316328-24462097-38515754","pred":"source","obj":"2_test"},{"subj":"31316328-24462097-38515755","pred":"source","obj":"2_test"},{"subj":"31316328-30458231-38515756","pred":"source","obj":"2_test"},{"subj":"31316328-17127563-38515757","pred":"source","obj":"2_test"},{"subj":"31316328-18718468-38515758","pred":"source","obj":"2_test"},{"subj":"31316328-19095969-38515759","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"31316328-24462097-631210","span":{"begin":153,"end":157},"obj":"24462097"},{"id":"31316328-24462097-631211","span":{"begin":352,"end":356},"obj":"24462097"},{"id":"31316328-24462097-631212","span":{"begin":478,"end":482},"obj":"24462097"},{"id":"31316328-30458231-631213","span":{"begin":667,"end":671},"obj":"30458231"},{"id":"31316328-17127563-631214","span":{"begin":859,"end":863},"obj":"17127563"},{"id":"31316328-18718468-631215","span":{"begin":877,"end":881},"obj":"18718468"},{"id":"31316328-19095969-631216","span":{"begin":896,"end":900},"obj":"19095969"}],"attributes":[{"subj":"31316328-24462097-631210","pred":"source","obj":"0_colil"},{"subj":"31316328-24462097-631211","pred":"source","obj":"0_colil"},{"subj":"31316328-24462097-631212","pred":"source","obj":"0_colil"},{"subj":"31316328-30458231-631213","pred":"source","obj":"0_colil"},{"subj":"31316328-17127563-631214","pred":"source","obj":"0_colil"},{"subj":"31316328-18718468-631215","pred":"source","obj":"0_colil"},{"subj":"31316328-19095969-631216","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#c293ec","default":true},{"id":"0_colil","color":"#93eca8"}]}]}}