PMC:6610326 / 51541-52245
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610326","sourcedb":"PMC","sourceid":"6610326","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610326","text":"Whilst these animal studies demonstrate that ALS spreads within MNs that are connected synaptically, a small portion of patients do not display this contiguous spreading of pathology, however. This implies the existence of alternative mechanisms of disease progression (Fujimura-Kiyono et al., 2011; Gargiulo-Monachelli et al., 2012), such as the transfer of misfolded proteins in nanotubules or exosomes (Nonaka et al., 2013; Sundaramoorthy et al., 2013; Grad et al., 2014; Ding et al., 2015; Feiler et al., 2015; Westergard et al., 2016). Interestingly, it has been suggested that the vulnerability of specific MN populations is associated with the spread of neurodegeneration in ALS (Fu et al., 2018).","tracks":[{"project":"2_test","denotations":[{"id":"31316328-21921087-38515619","span":{"begin":294,"end":298},"obj":"21921087"},{"id":"31316328-22248150-38515620","span":{"begin":328,"end":332},"obj":"22248150"},{"id":"31316328-23831027-38515621","span":{"begin":421,"end":425},"obj":"23831027"},{"id":"31316328-23765103-38515622","span":{"begin":450,"end":454},"obj":"23765103"},{"id":"31316328-24550511-38515623","span":{"begin":469,"end":473},"obj":"24550511"},{"id":"31316328-26172304-38515624","span":{"begin":488,"end":492},"obj":"26172304"},{"id":"31316328-26598621-38515625","span":{"begin":509,"end":513},"obj":"26598621"},{"id":"31316328-27732842-38515626","span":{"begin":534,"end":538},"obj":"27732842"},{"id":"31316328-30250262-38515627","span":{"begin":698,"end":702},"obj":"30250262"}],"attributes":[{"subj":"31316328-21921087-38515619","pred":"source","obj":"2_test"},{"subj":"31316328-22248150-38515620","pred":"source","obj":"2_test"},{"subj":"31316328-23831027-38515621","pred":"source","obj":"2_test"},{"subj":"31316328-23765103-38515622","pred":"source","obj":"2_test"},{"subj":"31316328-24550511-38515623","pred":"source","obj":"2_test"},{"subj":"31316328-26172304-38515624","pred":"source","obj":"2_test"},{"subj":"31316328-26598621-38515625","pred":"source","obj":"2_test"},{"subj":"31316328-27732842-38515626","pred":"source","obj":"2_test"},{"subj":"31316328-30250262-38515627","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"31316328-21921087-631076","span":{"begin":294,"end":298},"obj":"21921087"},{"id":"31316328-22248150-631077","span":{"begin":328,"end":332},"obj":"22248150"},{"id":"31316328-23831027-631078","span":{"begin":421,"end":425},"obj":"23831027"},{"id":"31316328-23765103-631079","span":{"begin":450,"end":454},"obj":"23765103"},{"id":"31316328-24550511-631080","span":{"begin":469,"end":473},"obj":"24550511"},{"id":"31316328-26172304-631081","span":{"begin":488,"end":492},"obj":"26172304"},{"id":"31316328-26598621-631082","span":{"begin":509,"end":513},"obj":"26598621"},{"id":"31316328-27732842-631083","span":{"begin":534,"end":538},"obj":"27732842"},{"id":"31316328-30250262-631084","span":{"begin":698,"end":702},"obj":"30250262"}],"attributes":[{"subj":"31316328-21921087-631076","pred":"source","obj":"0_colil"},{"subj":"31316328-22248150-631077","pred":"source","obj":"0_colil"},{"subj":"31316328-23831027-631078","pred":"source","obj":"0_colil"},{"subj":"31316328-23765103-631079","pred":"source","obj":"0_colil"},{"subj":"31316328-24550511-631080","pred":"source","obj":"0_colil"},{"subj":"31316328-26172304-631081","pred":"source","obj":"0_colil"},{"subj":"31316328-26598621-631082","pred":"source","obj":"0_colil"},{"subj":"31316328-27732842-631083","pred":"source","obj":"0_colil"},{"subj":"31316328-30250262-631084","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecea","default":true},{"id":"0_colil","color":"#ecd093"}]}]}}