PMC:6610326 / 36477-37281 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-8209258-38515512","span":{"begin":315,"end":319},"obj":"8209258"},{"id":"31316328-15519671-38515513","span":{"begin":339,"end":343},"obj":"15519671"},{"id":"31316328-15519671-38515514","span":{"begin":398,"end":402},"obj":"15519671"},{"id":"31316328-15519671-38515515","span":{"begin":459,"end":463},"obj":"15519671"},{"id":"31316328-9419057-38515516","span":{"begin":520,"end":524},"obj":"9419057"},{"id":"31316328-15519671-38515517","span":{"begin":579,"end":583},"obj":"15519671"},{"id":"31316328-7605627-38515518","span":{"begin":620,"end":624},"obj":"7605627"},{"id":"31316328-17276077-38515519","span":{"begin":644,"end":648},"obj":"17276077"},{"id":"31316328-9052802-38515520","span":{"begin":690,"end":694},"obj":"9052802"},{"id":"31316328-7846037-38515521","span":{"begin":742,"end":746},"obj":"7846037"},{"id":"31316328-17146286-38515522","span":{"begin":786,"end":790},"obj":"17146286"}],"text":"Table 6 Commonly used SOD1-transgenic mouse models of ALS and their phenotypes in relation to transgenic expression.\nSOD1 mouse models Transgene copies SOD1 protein levels in the CNS (human/mouse) Disease onset (days) Survival (months) References\nB6SJL-TgN(SOD1-G93A)1Gur 34 17 90 3.5–4.5 Gurney et al., 1994; Alexander et al., 2004\nSOD1-G93A Drop Copy#3 13 – – 6 Alexander et al., 2004\nSOD1-G93A Drop Copy#4 11 – – 6.5 Alexander et al., 2004\nB6SJL-TgN(SOD1-G93A)dl1Gur 10 8–10 168 8.3 Gurney, 1997\nSOD1-G93A Drop Copy#1 4 – – 21 Alexander et al., 2004\nG37R – 4–12 105 5 Wong et al., 1995; Haenggeli et al., 2007\nG85R – 0.2–1 240 8.5 Bruijn et al., 1997\nG86R (M1 line) – – 90–120 4 Ripps et al., 1995\nD90A – – 350 13.5 Jonsson et al., 2006\n(–), unknown."}

{"project":"0_colil","denotations":[{"id":"31316328-8209258-630969","span":{"begin":315,"end":319},"obj":"8209258"},{"id":"31316328-15519671-630970","span":{"begin":339,"end":343},"obj":"15519671"},{"id":"31316328-15519671-630971","span":{"begin":398,"end":402},"obj":"15519671"},{"id":"31316328-15519671-630972","span":{"begin":459,"end":463},"obj":"15519671"},{"id":"31316328-9419057-630973","span":{"begin":520,"end":524},"obj":"9419057"},{"id":"31316328-15519671-630974","span":{"begin":579,"end":583},"obj":"15519671"},{"id":"31316328-7605627-630975","span":{"begin":620,"end":624},"obj":"7605627"},{"id":"31316328-17276077-630976","span":{"begin":644,"end":648},"obj":"17276077"},{"id":"31316328-9052802-630977","span":{"begin":690,"end":694},"obj":"9052802"},{"id":"31316328-7846037-630978","span":{"begin":742,"end":746},"obj":"7846037"},{"id":"31316328-17146286-630979","span":{"begin":786,"end":790},"obj":"17146286"}],"text":"Table 6 Commonly used SOD1-transgenic mouse models of ALS and their phenotypes in relation to transgenic expression.\nSOD1 mouse models Transgene copies SOD1 protein levels in the CNS (human/mouse) Disease onset (days) Survival (months) References\nB6SJL-TgN(SOD1-G93A)1Gur 34 17 90 3.5–4.5 Gurney et al., 1994; Alexander et al., 2004\nSOD1-G93A Drop Copy#3 13 – – 6 Alexander et al., 2004\nSOD1-G93A Drop Copy#4 11 – – 6.5 Alexander et al., 2004\nB6SJL-TgN(SOD1-G93A)dl1Gur 10 8–10 168 8.3 Gurney, 1997\nSOD1-G93A Drop Copy#1 4 – – 21 Alexander et al., 2004\nG37R – 4–12 105 5 Wong et al., 1995; Haenggeli et al., 2007\nG85R – 0.2–1 240 8.5 Bruijn et al., 1997\nG86R (M1 line) – – 90–120 4 Ripps et al., 1995\nD90A – – 350 13.5 Jonsson et al., 2006\n(–), unknown."}