PMC:6610326 / 15334-16771 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-14784872-38515320","span":{"begin":958,"end":962},"obj":"14784872"},{"id":"31316328-874534-38515321","span":{"begin":981,"end":985},"obj":"874534"},{"id":"31316328-7108785-38515322","span":{"begin":1000,"end":1004},"obj":"7108785"},{"id":"31316328-19651609-38515323","span":{"begin":1024,"end":1028},"obj":"19651609"},{"id":"31316328-19954518-38515324","span":{"begin":1050,"end":1054},"obj":"19954518"},{"id":"31316328-14301026-38515325","span":{"begin":1076,"end":1080},"obj":"14301026"},{"id":"31316328-722563-38515326","span":{"begin":1104,"end":1108},"obj":"722563"},{"id":"31316328-7689771-38515327","span":{"begin":1132,"end":1136},"obj":"7689771"},{"id":"31316328-466479-38515328","span":{"begin":1164,"end":1168},"obj":"466479"},{"id":"31316328-13725574-38515329","span":{"begin":1189,"end":1193},"obj":"13725574"},{"id":"31316328-9527903-38515330","span":{"begin":1216,"end":1220},"obj":"9527903"},{"id":"31316328-27930290-38515331","span":{"begin":1252,"end":1256},"obj":"27930290"},{"id":"31316328-4261815-38515332","span":{"begin":1277,"end":1281},"obj":"4261815"},{"id":"31316328-3372722-38515333","span":{"begin":1305,"end":1309},"obj":"3372722"},{"id":"31316328-22420030-38515334","span":{"begin":1330,"end":1334},"obj":"22420030"},{"id":"31316328-19651609-38515335","span":{"begin":1355,"end":1359},"obj":"19651609"},{"id":"31316328-23761886-38515336","span":{"begin":1381,"end":1385},"obj":"23761886"},{"id":"31316328-22273508-38515337","span":{"begin":1405,"end":1409},"obj":"22273508"},{"id":"31316328-22723712-38515338","span":{"begin":1431,"end":1435},"obj":"22723712"}],"text":"Table 2 Comparison of α- and γ-spinal motor neurons.\nSpinal α-MN Spinal γ-MN\nTarget muscle fiber Extrafusal1 Intrafusal1\nSoma size Larger2,3,4,5 Smaller2,3,4,5\nAxon diameter Larger2 Thinner2\nDendrite branching More2 Less2\nMotor unit size (innervation ratio) Larger6 Smaller6\nMembrane input resistance Larger7 Smaller7\nFiring Subtype-dependent8 Subtype-dependent8\nAxon conduction velocity Faster2,7,9 Slower2,7,9\nAfterhyperpolarization duration Subtype-dependent7,9 Variable7,9\nSpinal reflex Yes10 No10\nAffected in ALS Yes11,12 Less11,12\nAffected in aging Yes13,14 No13,14\nMarkers Osteopontin15RBFOX3/NeuN16Hb9::GFP5NKAα117 (adult) Err316Weak NeuN5,16NKAα317 (adult)ESRRG16GFRα15HTR1D18 (early marker)WNT7A19 (late embryonic stage)\nESRRG, estrogen-related receptor gamma; GFRα1, GDNF family receptor alpha 1; HTR1D, serotonin receptor 1D; NAKα1/3, Na+/K+-ATPases 1/3; RBFOX3, RNA binding protein fox-1 homolog 3. 1(Kuffler et al., 1951), 2(Burke et al., 1977), 3(Westbury, 1982), 4(Friese et al., 2009), 5(Shneider et al., 2009), 6(Adal and Barker, 1965), 7(Kemm and Westbury, 1978), 8(Murphy and Martin, 1993), 9(Gustafsson and Lipski, 1979), 10(Eccles et al., 1960), 11(Mohajeri et al., 1998), 12(Lalancette-Hebert et al., 2016), 13(Swash and Fox, 1972), 14(Hashizume et al., 1988), 15(Misawa et al., 2012), 16(Friese et al., 2009), 17(Edwards et al., 2013), 18(Enjin et al., 2012), 19(Ashrafi et al., 2012)."}

{"project":"0_colil","denotations":[{"id":"31316328-14784872-630777","span":{"begin":958,"end":962},"obj":"14784872"},{"id":"31316328-874534-630778","span":{"begin":981,"end":985},"obj":"874534"},{"id":"31316328-7108785-630779","span":{"begin":1000,"end":1004},"obj":"7108785"},{"id":"31316328-19651609-630780","span":{"begin":1024,"end":1028},"obj":"19651609"},{"id":"31316328-19954518-630781","span":{"begin":1050,"end":1054},"obj":"19954518"},{"id":"31316328-14301026-630782","span":{"begin":1076,"end":1080},"obj":"14301026"},{"id":"31316328-722563-630783","span":{"begin":1104,"end":1108},"obj":"722563"},{"id":"31316328-7689771-630784","span":{"begin":1132,"end":1136},"obj":"7689771"},{"id":"31316328-466479-630785","span":{"begin":1164,"end":1168},"obj":"466479"},{"id":"31316328-13725574-630786","span":{"begin":1189,"end":1193},"obj":"13725574"},{"id":"31316328-9527903-630787","span":{"begin":1216,"end":1220},"obj":"9527903"},{"id":"31316328-27930290-630788","span":{"begin":1252,"end":1256},"obj":"27930290"},{"id":"31316328-4261815-630789","span":{"begin":1277,"end":1281},"obj":"4261815"},{"id":"31316328-3372722-630790","span":{"begin":1305,"end":1309},"obj":"3372722"},{"id":"31316328-22420030-630791","span":{"begin":1330,"end":1334},"obj":"22420030"},{"id":"31316328-19651609-630792","span":{"begin":1355,"end":1359},"obj":"19651609"},{"id":"31316328-23761886-630793","span":{"begin":1381,"end":1385},"obj":"23761886"},{"id":"31316328-22273508-630794","span":{"begin":1405,"end":1409},"obj":"22273508"},{"id":"31316328-22723712-630795","span":{"begin":1431,"end":1435},"obj":"22723712"}],"text":"Table 2 Comparison of α- and γ-spinal motor neurons.\nSpinal α-MN Spinal γ-MN\nTarget muscle fiber Extrafusal1 Intrafusal1\nSoma size Larger2,3,4,5 Smaller2,3,4,5\nAxon diameter Larger2 Thinner2\nDendrite branching More2 Less2\nMotor unit size (innervation ratio) Larger6 Smaller6\nMembrane input resistance Larger7 Smaller7\nFiring Subtype-dependent8 Subtype-dependent8\nAxon conduction velocity Faster2,7,9 Slower2,7,9\nAfterhyperpolarization duration Subtype-dependent7,9 Variable7,9\nSpinal reflex Yes10 No10\nAffected in ALS Yes11,12 Less11,12\nAffected in aging Yes13,14 No13,14\nMarkers Osteopontin15RBFOX3/NeuN16Hb9::GFP5NKAα117 (adult) Err316Weak NeuN5,16NKAα317 (adult)ESRRG16GFRα15HTR1D18 (early marker)WNT7A19 (late embryonic stage)\nESRRG, estrogen-related receptor gamma; GFRα1, GDNF family receptor alpha 1; HTR1D, serotonin receptor 1D; NAKα1/3, Na+/K+-ATPases 1/3; RBFOX3, RNA binding protein fox-1 homolog 3. 1(Kuffler et al., 1951), 2(Burke et al., 1977), 3(Westbury, 1982), 4(Friese et al., 2009), 5(Shneider et al., 2009), 6(Adal and Barker, 1965), 7(Kemm and Westbury, 1978), 8(Murphy and Martin, 1993), 9(Gustafsson and Lipski, 1979), 10(Eccles et al., 1960), 11(Mohajeri et al., 1998), 12(Lalancette-Hebert et al., 2016), 13(Swash and Fox, 1972), 14(Hashizume et al., 1988), 15(Misawa et al., 2012), 16(Friese et al., 2009), 17(Edwards et al., 2013), 18(Enjin et al., 2012), 19(Ashrafi et al., 2012)."}