PMC:6610326 / 102295-103393
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610326","sourcedb":"PMC","sourceid":"6610326","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610326","text":"Kinesin-dependant axonal transport is also disrupted in ALS. Oxidized forms of wild type SOD1 immunopurified from SALS tissues inhibited kinesin-based fast axonal transport (Bosco et al., 2010). However, no interaction between members of the kinesin family (KIF5A, 5B or 5C) and SOD1 was detected in SOD1G93A mice. High expression of KIF proteins is also associated with neurodegeneration. KIF5C was abundantly expressed in vulnerable spinal MNs in SOD1G93A mice (Kanai et al., 2000), but a marked reduction in KIF3Aβ levels was detected in the motor cortex of SALS patients (Pantelidou et al., 2007). Furthermore, reduced kinesin-associated protein 3 (KIFAP3) expression was linked to an increase in the survival of ALS patients (Landers et al., 2009) and changes in the transport of choline acetyltransferase transporter (ChAT) along axons. KIF5C is expressed more in rat spinal MNs than oculomotor and hypoglossal MNs (Hedlund et al., 2010), However, further work is necessary to determine if this is related to ALS, and to examine whether KIFs are differentially expressed in neuronal subtypes.","tracks":[{"project":"2_test","denotations":[{"id":"31316328-20953194-38515967","span":{"begin":188,"end":192},"obj":"20953194"},{"id":"31316328-10964943-38515968","span":{"begin":478,"end":482},"obj":"10964943"},{"id":"31316328-17418584-38515969","span":{"begin":595,"end":599},"obj":"17418584"},{"id":"31316328-19451621-38515970","span":{"begin":747,"end":751},"obj":"19451621"},{"id":"31316328-20826431-38515971","span":{"begin":938,"end":942},"obj":"20826431"}],"attributes":[{"subj":"31316328-20953194-38515967","pred":"source","obj":"2_test"},{"subj":"31316328-10964943-38515968","pred":"source","obj":"2_test"},{"subj":"31316328-17418584-38515969","pred":"source","obj":"2_test"},{"subj":"31316328-19451621-38515970","pred":"source","obj":"2_test"},{"subj":"31316328-20826431-38515971","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"31316328-20953194-631424","span":{"begin":188,"end":192},"obj":"20953194"},{"id":"31316328-10964943-631425","span":{"begin":478,"end":482},"obj":"10964943"},{"id":"31316328-17418584-631426","span":{"begin":595,"end":599},"obj":"17418584"},{"id":"31316328-19451621-631427","span":{"begin":747,"end":751},"obj":"19451621"},{"id":"31316328-20826431-631428","span":{"begin":938,"end":942},"obj":"20826431"}],"attributes":[{"subj":"31316328-20953194-631424","pred":"source","obj":"0_colil"},{"subj":"31316328-10964943-631425","pred":"source","obj":"0_colil"},{"subj":"31316328-17418584-631426","pred":"source","obj":"0_colil"},{"subj":"31316328-19451621-631427","pred":"source","obj":"0_colil"},{"subj":"31316328-20826431-631428","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93deec","default":true},{"id":"0_colil","color":"#ecdf93"}]}]}}