PMC:6582309 / 30352-31744 JSONTXT

{"project":"2_test","denotations":[{"id":"31249505-1868335-38601629","span":{"begin":128,"end":132},"obj":"1868335"},{"id":"31249505-1329997-38601630","span":{"begin":149,"end":153},"obj":"1329997"},{"id":"31249505-10332828-38601631","span":{"begin":170,"end":174},"obj":"10332828"},{"id":"31249505-11016539-38601632","span":{"begin":190,"end":194},"obj":"11016539"},{"id":"31249505-25588378-38601633","span":{"begin":219,"end":223},"obj":"25588378"},{"id":"31249505-26247394-38601634","span":{"begin":241,"end":245},"obj":"26247394"},{"id":"31249505-26922972-38601635","span":{"begin":261,"end":265},"obj":"26922972"},{"id":"31249505-27669976-38601636","span":{"begin":281,"end":285},"obj":"27669976"},{"id":"31249505-29441010-38601637","span":{"begin":305,"end":309},"obj":"29441010"},{"id":"31249505-18184371-38601638","span":{"begin":649,"end":653},"obj":"18184371"},{"id":"31249505-22239863-38601639","span":{"begin":672,"end":676},"obj":"22239863"},{"id":"31249505-27669976-38601640","span":{"begin":957,"end":961},"obj":"27669976"},{"id":"31249505-26922972-38601641","span":{"begin":1061,"end":1065},"obj":"26922972"},{"id":"31249505-2385040-38601642","span":{"begin":1167,"end":1171},"obj":"2385040"},{"id":"31249505-30482198-38601643","span":{"begin":1322,"end":1326},"obj":"30482198"}],"text":"In aged dogs Aβ deposits are detected both in the brain parenchyma and in the walls of cerebral blood vessels (Ishihara et al., 1991; Uchida et al., 1992; Borràs et al., 1999; Colle et al., 2000; Brettschneider et al., 2015; Schmidt et al., 2015; Ozawa et al., 2016; Nešić et al., 2017; Rusbridge et al., 2018), further suggesting similarities between AD in humans and CCD in dogs (Figures 2, 3). The amyloidotic blood vessels in the brains of dogs were observed by Congo red stainings as well as by antibodies directed against Aβ. Vascular Aβ deposition mainly consists of Aβ40 in humans, but both Aβ40 and Aβ42 were detected in dogs (Kumar-Singh, 2008; Chambers et al., 2012). In canine CAA, the most affected region is the frontal cortex, where Aβ is often present in microvascular parenchymal lesions in elderly dogs. In dogs with CCD an overlap between the density and anatomical distribution of CAA and parenchymal plaques was observed (Nešić et al., 2017). The CAA consistently increased with age, but did not correlate with the CCD score (Ozawa et al., 2016). Intracerebral hemorrhages have also been described in association with CAA in dogs (Uchida et al., 1990). A recent case reported multiple infarcts and brain hemorrhages in a dog with CAA and CCD, with cerebral and vascular Aβ deposits (Rodrigues et al., 2018). Pathological hallmarks of CCD and AD are summarized in Table 2."}

{"project":"0_colil","denotations":[{"id":"31249505-1868335-737054","span":{"begin":128,"end":132},"obj":"1868335"},{"id":"31249505-1329997-737055","span":{"begin":149,"end":153},"obj":"1329997"},{"id":"31249505-10332828-737056","span":{"begin":170,"end":174},"obj":"10332828"},{"id":"31249505-11016539-737057","span":{"begin":190,"end":194},"obj":"11016539"},{"id":"31249505-25588378-737058","span":{"begin":219,"end":223},"obj":"25588378"},{"id":"31249505-26247394-737059","span":{"begin":241,"end":245},"obj":"26247394"},{"id":"31249505-26922972-737060","span":{"begin":261,"end":265},"obj":"26922972"},{"id":"31249505-27669976-737061","span":{"begin":281,"end":285},"obj":"27669976"},{"id":"31249505-29441010-737062","span":{"begin":305,"end":309},"obj":"29441010"},{"id":"31249505-18184371-737063","span":{"begin":649,"end":653},"obj":"18184371"},{"id":"31249505-22239863-737064","span":{"begin":672,"end":676},"obj":"22239863"},{"id":"31249505-27669976-737065","span":{"begin":957,"end":961},"obj":"27669976"},{"id":"31249505-26922972-737066","span":{"begin":1061,"end":1065},"obj":"26922972"},{"id":"31249505-2385040-737067","span":{"begin":1167,"end":1171},"obj":"2385040"},{"id":"31249505-30482198-737068","span":{"begin":1322,"end":1326},"obj":"30482198"}],"text":"In aged dogs Aβ deposits are detected both in the brain parenchyma and in the walls of cerebral blood vessels (Ishihara et al., 1991; Uchida et al., 1992; Borràs et al., 1999; Colle et al., 2000; Brettschneider et al., 2015; Schmidt et al., 2015; Ozawa et al., 2016; Nešić et al., 2017; Rusbridge et al., 2018), further suggesting similarities between AD in humans and CCD in dogs (Figures 2, 3). The amyloidotic blood vessels in the brains of dogs were observed by Congo red stainings as well as by antibodies directed against Aβ. Vascular Aβ deposition mainly consists of Aβ40 in humans, but both Aβ40 and Aβ42 were detected in dogs (Kumar-Singh, 2008; Chambers et al., 2012). In canine CAA, the most affected region is the frontal cortex, where Aβ is often present in microvascular parenchymal lesions in elderly dogs. In dogs with CCD an overlap between the density and anatomical distribution of CAA and parenchymal plaques was observed (Nešić et al., 2017). The CAA consistently increased with age, but did not correlate with the CCD score (Ozawa et al., 2016). Intracerebral hemorrhages have also been described in association with CAA in dogs (Uchida et al., 1990). A recent case reported multiple infarcts and brain hemorrhages in a dog with CAA and CCD, with cerebral and vascular Aβ deposits (Rodrigues et al., 2018). Pathological hallmarks of CCD and AD are summarized in Table 2."}