PMC:6582309 / 13598-14640 JSONTXT

{"project":"2_test","denotations":[{"id":"31249505-8295657-38601503","span":{"begin":262,"end":266},"obj":"8295657"},{"id":"31249505-7491048-38601504","span":{"begin":289,"end":293},"obj":"7491048"},{"id":"31249505-16775693-38601505","span":{"begin":312,"end":316},"obj":"16775693"},{"id":"31249505-16423332-38601506","span":{"begin":333,"end":337},"obj":"16423332"},{"id":"31249505-26553522-38601507","span":{"begin":354,"end":358},"obj":"26553522"},{"id":"31249505-21557687-38601508","span":{"begin":499,"end":503},"obj":"21557687"},{"id":"31249505-26922972-38601509","span":{"begin":519,"end":523},"obj":"26922972"},{"id":"31249505-8295657-38601510","span":{"begin":881,"end":885},"obj":"8295657"},{"id":"31249505-21256508-38601511","span":{"begin":898,"end":902},"obj":"21256508"},{"id":"31249505-20354705-38601512","span":{"begin":1036,"end":1040},"obj":"20354705"}],"text":"Amyloid-β was found to be present in the form of insoluble plaques in the area of the cerebral cortex in humans and dogs, and cognitive impairment in elderly dogs was in some studies strongly associated with the accumulation of Aβ in the brain (Cummings et al., 1993; Cummings and Cotman, 1995; Pugliese et al., 2006; Rofina et al., 2006; Barnes et al., 2016). However, in two other studies there was no significant correlation between the amount of Aβ brain load and CCD symptoms (Chambers et al., 2011; Ozawa et al., 2016) so the clear connection between Aβ load in the brain and clinical signs of CCD has not been firmly established yet. Although Aβ plaques are generally detected as extracellular deposits of diffuse and neuritic plaques in humans and dogs, some studies also reported the presence of Aβ deposits inside individual neurons in the canine brain (Cummings et al., 1993; Yu et al., 2011). Similarly, intraneuronal Aβ accumulation in human AD brains has been reported by many groups (reviewed in detail by Gouras et al., 2010)."}

{"project":"0_colil","denotations":[{"id":"31249505-8295657-736928","span":{"begin":262,"end":266},"obj":"8295657"},{"id":"31249505-7491048-736929","span":{"begin":289,"end":293},"obj":"7491048"},{"id":"31249505-16775693-736930","span":{"begin":312,"end":316},"obj":"16775693"},{"id":"31249505-16423332-736931","span":{"begin":333,"end":337},"obj":"16423332"},{"id":"31249505-26553522-736932","span":{"begin":354,"end":358},"obj":"26553522"},{"id":"31249505-21557687-736933","span":{"begin":499,"end":503},"obj":"21557687"},{"id":"31249505-26922972-736934","span":{"begin":519,"end":523},"obj":"26922972"},{"id":"31249505-8295657-736935","span":{"begin":881,"end":885},"obj":"8295657"},{"id":"31249505-21256508-736936","span":{"begin":898,"end":902},"obj":"21256508"},{"id":"31249505-20354705-736937","span":{"begin":1036,"end":1040},"obj":"20354705"}],"text":"Amyloid-β was found to be present in the form of insoluble plaques in the area of the cerebral cortex in humans and dogs, and cognitive impairment in elderly dogs was in some studies strongly associated with the accumulation of Aβ in the brain (Cummings et al., 1993; Cummings and Cotman, 1995; Pugliese et al., 2006; Rofina et al., 2006; Barnes et al., 2016). However, in two other studies there was no significant correlation between the amount of Aβ brain load and CCD symptoms (Chambers et al., 2011; Ozawa et al., 2016) so the clear connection between Aβ load in the brain and clinical signs of CCD has not been firmly established yet. Although Aβ plaques are generally detected as extracellular deposits of diffuse and neuritic plaques in humans and dogs, some studies also reported the presence of Aβ deposits inside individual neurons in the canine brain (Cummings et al., 1993; Yu et al., 2011). Similarly, intraneuronal Aβ accumulation in human AD brains has been reported by many groups (reviewed in detail by Gouras et al., 2010)."}