PMC:6562565 / 69108-69671 JSONTXT

{"project":"MyTest","denotations":[{"id":"31244820-22174255-35366426","span":{"begin":133,"end":136},"obj":"22174255"},{"id":"31244820-28344743-35366427","span":{"begin":138,"end":141},"obj":"28344743"},{"id":"31244820-28250717-35366427","span":{"begin":138,"end":141},"obj":"28250717"},{"id":"31244820-25071979-35366427","span":{"begin":138,"end":141},"obj":"25071979"},{"id":"31244820-19855167-35366427","span":{"begin":138,"end":141},"obj":"19855167"},{"id":"31244820-25323906-35366427","span":{"begin":138,"end":141},"obj":"25323906"},{"id":"31244820-23776241-35366428","span":{"begin":212,"end":215},"obj":"23776241"},{"id":"31244820-19337853-35366429","span":{"begin":222,"end":225},"obj":"19337853"},{"id":"31244820-23776241-35366430","span":{"begin":237,"end":240},"obj":"23776241"},{"id":"31244820-26921334-35366431","span":{"begin":247,"end":250},"obj":"26921334"},{"id":"31244820-26629888-35366431","span":{"begin":247,"end":250},"obj":"26629888"},{"id":"31244820-29367423-35366431","span":{"begin":247,"end":250},"obj":"29367423"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"It is well documented that radiotherapy (RT) as well as several chemotherapeutic (CT) drugs have the capacity to induce ATP release (406, 429–433). Since such regimens also elevate the expression levels of CD39 (405, 407, 434) and CD73 (405, 407, 435–437), it is possible that the concentration of interstitial adenosine in the TME rises sharply upon application of these treatments. Therefore, several investigators have explored whether concomitant provision of agents targeting the adenosine axis increase the anti-tumor efficacy of RT or of various CT agents."}

{"project":"TEST0","denotations":[{"id":"31244820-133-140-3850574","span":{"begin":133,"end":136},"obj":"[\"22174255\"]"},{"id":"31244820-138-145-3850575","span":{"begin":138,"end":141},"obj":"[\"28344743\", \"28250717\", \"25071979\", \"19855167\", \"25323906\"]"},{"id":"31244820-64-71-3850576","span":{"begin":212,"end":215},"obj":"[\"23776241\"]"},{"id":"31244820-74-81-3850577","span":{"begin":222,"end":225},"obj":"[\"19337853\"]"},{"id":"31244820-89-96-3850578","span":{"begin":237,"end":240},"obj":"[\"23776241\"]"},{"id":"31244820-99-106-3850579","span":{"begin":247,"end":250},"obj":"[\"26921334\", \"26629888\", \"29367423\"]"}],"text":"It is well documented that radiotherapy (RT) as well as several chemotherapeutic (CT) drugs have the capacity to induce ATP release (406, 429–433). Since such regimens also elevate the expression levels of CD39 (405, 407, 434) and CD73 (405, 407, 435–437), it is possible that the concentration of interstitial adenosine in the TME rises sharply upon application of these treatments. Therefore, several investigators have explored whether concomitant provision of agents targeting the adenosine axis increase the anti-tumor efficacy of RT or of various CT agents."}

{"project":"2_test","denotations":[{"id":"31244820-22174255-35366426","span":{"begin":133,"end":136},"obj":"22174255"},{"id":"31244820-28344743-35366427","span":{"begin":138,"end":141},"obj":"28344743"},{"id":"31244820-28250717-35366427","span":{"begin":138,"end":141},"obj":"28250717"},{"id":"31244820-25071979-35366427","span":{"begin":138,"end":141},"obj":"25071979"},{"id":"31244820-19855167-35366427","span":{"begin":138,"end":141},"obj":"19855167"},{"id":"31244820-25323906-35366427","span":{"begin":138,"end":141},"obj":"25323906"},{"id":"31244820-23776241-35366428","span":{"begin":212,"end":215},"obj":"23776241"},{"id":"31244820-19337853-35366429","span":{"begin":222,"end":225},"obj":"19337853"},{"id":"31244820-23776241-35366430","span":{"begin":237,"end":240},"obj":"23776241"},{"id":"31244820-26921334-35366431","span":{"begin":247,"end":250},"obj":"26921334"},{"id":"31244820-26629888-35366431","span":{"begin":247,"end":250},"obj":"26629888"},{"id":"31244820-29367423-35366431","span":{"begin":247,"end":250},"obj":"29367423"}],"text":"It is well documented that radiotherapy (RT) as well as several chemotherapeutic (CT) drugs have the capacity to induce ATP release (406, 429–433). Since such regimens also elevate the expression levels of CD39 (405, 407, 434) and CD73 (405, 407, 435–437), it is possible that the concentration of interstitial adenosine in the TME rises sharply upon application of these treatments. Therefore, several investigators have explored whether concomitant provision of agents targeting the adenosine axis increase the anti-tumor efficacy of RT or of various CT agents."}