PMC:6562565 / 42144-43170
Annnotations
MyTest
{"project":"MyTest","denotations":[{"id":"31244820-28165340-35366105","span":{"begin":50,"end":53},"obj":"28165340"},{"id":"31244820-20179192-35366106","span":{"begin":76,"end":79},"obj":"20179192"},{"id":"31244820-29923026-35366107","span":{"begin":81,"end":84},"obj":"29923026"},{"id":"31244820-29802128-35366108","span":{"begin":100,"end":103},"obj":"29802128"},{"id":"31244820-16916931-35366109","span":{"begin":123,"end":125},"obj":"16916931"},{"id":"31244820-16916931-35366110","span":{"begin":171,"end":173},"obj":"16916931"},{"id":"31244820-28165340-35366111","span":{"begin":175,"end":178},"obj":"28165340"},{"id":"31244820-29802128-35366112","span":{"begin":180,"end":183},"obj":"29802128"},{"id":"31244820-29802128-35366113","span":{"begin":193,"end":196},"obj":"29802128"},{"id":"31244820-28165340-35366114","span":{"begin":208,"end":211},"obj":"28165340"},{"id":"31244820-20179192-35366115","span":{"begin":213,"end":216},"obj":"20179192"},{"id":"31244820-28165340-35366116","span":{"begin":242,"end":245},"obj":"28165340"},{"id":"31244820-29923026-35366117","span":{"begin":268,"end":271},"obj":"29923026"},{"id":"31244820-20179192-35366118","span":{"begin":293,"end":296},"obj":"20179192"},{"id":"31244820-29802128-35366119","span":{"begin":322,"end":325},"obj":"29802128"},{"id":"31244820-28165340-35366120","span":{"begin":338,"end":341},"obj":"28165340"},{"id":"31244820-16916931-35366121","span":{"begin":359,"end":361},"obj":"16916931"},{"id":"31244820-28165340-35366122","span":{"begin":398,"end":401},"obj":"28165340"},{"id":"31244820-29923026-35366123","span":{"begin":403,"end":406},"obj":"29923026"},{"id":"31244820-28165340-35366124","span":{"begin":418,"end":421},"obj":"28165340"},{"id":"31244820-28165340-35366125","span":{"begin":430,"end":433},"obj":"28165340"},{"id":"31244820-16916931-35366126","span":{"begin":461,"end":463},"obj":"16916931"},{"id":"31244820-29802128-35366127","span":{"begin":465,"end":468},"obj":"29802128"},{"id":"31244820-29802128-35366128","span":{"begin":502,"end":505},"obj":"29802128"},{"id":"31244820-28165340-35366129","span":{"begin":521,"end":524},"obj":"28165340"},{"id":"31244820-20179192-35366130","span":{"begin":526,"end":529},"obj":"20179192"},{"id":"31244820-29923026-35366131","span":{"begin":531,"end":534},"obj":"29923026"},{"id":"31244820-29802128-35366132","span":{"begin":536,"end":539},"obj":"29802128"},{"id":"31244820-28165340-35366124","span":{"begin":418,"end":421},"obj":"28165340"},{"id":"31244820-29923026-35366133","span":{"begin":591,"end":594},"obj":"29923026"},{"id":"31244820-29923026-35366134","span":{"begin":655,"end":658},"obj":"29923026"},{"id":"31244820-28165340-35366135","span":{"begin":700,"end":703},"obj":"28165340"},{"id":"31244820-29923026-35366136","span":{"begin":790,"end":793},"obj":"29923026"},{"id":"31244820-29802128-35366137","span":{"begin":881,"end":884},"obj":"29802128"},{"id":"31244820-29923026-35366138","span":{"begin":933,"end":936},"obj":"29923026"},{"id":"31244820-29923026-35366139","span":{"begin":1022,"end":1025},"obj":"29923026"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"ACT \u0026 A2AR antagonism ➣ T cells:\nanti-HER2 CAR+ (135)\nOT-I (OVA-specific) (388, 396)\nTDLN-derived (402)\nReactive to CMS4 (38)\n➣ A2AR antagonists:\nCPI-444 (396)\nZM241385 (38, 135, 402)\nKW6002 (402)\nSCH58261 (135, 388) ➣ Breast: E0771- HER2 (135)\n➣ Melanoma: B16-OVA (396)\n➣ Ovarian: ID8-OVA (388)\n➣ Fibrosarcoma:\nMCA205 (402)\n24JK-HER2 (135)\n➣ Sarcoma CMS4 (38) ➣ Primary tumor expansion rate ↓ (135, 396)\nPD-1 ICB (135)\nIFN-γ (135)\n➣ Metastasis formation ↓ (38, 402)\nNon-myeloablative pretreatment (402)\n➣ Survival ↑ (135, 388, 396, 402) PD-1 ICB (135) ↑ Adoptively transferred T cells (396)↑ Tbet, 41BB, CD69 in/on adoptively transferred CD8+ cells (396)↑ IFN-γ+ adoptively transferred T cells (135)↑ Stimulation-induced IFN-γ, TNF-α production by adoptively transferred CD8+ T cells (396)↑ Stimulation-induced IFN-γ production by adoptively transferred CD8+ or CD4+ T cells (402)↑ Tbet, 41BB in/on endogenous CD44+ CD8+ cells (396)↑ Stimulation-induced IL-2, IFN-γ, TNF-α production by endogenous CD8+CD44+ T cells (396)"}
TEST0
{"project":"TEST0","denotations":[{"id":"31244820-16-23-3850253","span":{"begin":50,"end":53},"obj":"[\"28165340\"]"},{"id":"31244820-21-28-3850254","span":{"begin":76,"end":79},"obj":"[\"20179192\"]"},{"id":"31244820-26-33-3850255","span":{"begin":81,"end":84},"obj":"[\"29923026\"]"},{"id":"31244820-14-21-3850256","span":{"begin":100,"end":103},"obj":"[\"29802128\"]"},{"id":"31244820-18-24-3850257","span":{"begin":123,"end":125},"obj":"[\"16916931\"]"},{"id":"31244820-10-16-3850258","span":{"begin":171,"end":173},"obj":"[\"16916931\"]"},{"id":"31244820-14-21-3850259","span":{"begin":175,"end":178},"obj":"[\"28165340\"]"},{"id":"31244820-19-26-3850260","span":{"begin":180,"end":183},"obj":"[\"29802128\"]"},{"id":"31244820-8-15-3850261","span":{"begin":193,"end":196},"obj":"[\"29802128\"]"},{"id":"31244820-10-17-3850262","span":{"begin":208,"end":211},"obj":"[\"28165340\"]"},{"id":"31244820-15-22-3850263","span":{"begin":213,"end":216},"obj":"[\"20179192\"]"},{"id":"31244820-23-30-3850264","span":{"begin":242,"end":245},"obj":"[\"28165340\"]"},{"id":"31244820-21-28-3850265","span":{"begin":268,"end":271},"obj":"[\"29923026\"]"},{"id":"31244820-20-27-3850266","span":{"begin":293,"end":296},"obj":"[\"20179192\"]"},{"id":"31244820-8-15-3850267","span":{"begin":322,"end":325},"obj":"[\"29802128\"]"},{"id":"31244820-11-18-3850268","span":{"begin":338,"end":341},"obj":"[\"28165340\"]"},{"id":"31244820-16-22-3850269","span":{"begin":359,"end":361},"obj":"[\"16916931\"]"},{"id":"31244820-34-41-3850270","span":{"begin":398,"end":401},"obj":"[\"28165340\"]"},{"id":"31244820-39-46-3850271","span":{"begin":403,"end":406},"obj":"[\"29923026\"]"},{"id":"31244820-10-17-3850272","span":{"begin":418,"end":421},"obj":"[\"28165340\", \"28165340\"]"},{"id":"31244820-7-14-3850273","span":{"begin":430,"end":433},"obj":"[\"28165340\"]"},{"id":"31244820-26-32-3850274","span":{"begin":461,"end":463},"obj":"[\"16916931\"]"},{"id":"31244820-30-37-3850275","span":{"begin":465,"end":468},"obj":"[\"29802128\"]"},{"id":"31244820-32-39-3850276","span":{"begin":502,"end":505},"obj":"[\"29802128\"]"},{"id":"31244820-14-21-3850277","span":{"begin":521,"end":524},"obj":"[\"28165340\"]"},{"id":"31244820-19-26-3850278","span":{"begin":526,"end":529},"obj":"[\"20179192\"]"},{"id":"31244820-24-31-3850279","span":{"begin":531,"end":534},"obj":"[\"29923026\"]"},{"id":"31244820-29-36-3850280","span":{"begin":536,"end":539},"obj":"[\"29802128\"]"},{"id":"31244820-10-17-3850272","span":{"begin":418,"end":421},"obj":"[\"28165340\", \"28165340\"]"},{"id":"31244820-34-41-3850281","span":{"begin":591,"end":594},"obj":"[\"29923026\"]"},{"id":"31244820-98-105-3850282","span":{"begin":655,"end":658},"obj":"[\"29923026\"]"},{"id":"31244820-143-150-3850283","span":{"begin":700,"end":703},"obj":"[\"28165340\"]"},{"id":"31244820-233-240-3850284","span":{"begin":790,"end":793},"obj":"[\"29923026\"]"},{"id":"31244820-233-240-3850285","span":{"begin":881,"end":884},"obj":"[\"29802128\"]"},{"id":"31244820-234-241-3850286","span":{"begin":933,"end":936},"obj":"[\"29923026\"]"},{"id":"31244820-233-240-3850287","span":{"begin":1022,"end":1025},"obj":"[\"29923026\"]"}],"text":"ACT \u0026 A2AR antagonism ➣ T cells:\nanti-HER2 CAR+ (135)\nOT-I (OVA-specific) (388, 396)\nTDLN-derived (402)\nReactive to CMS4 (38)\n➣ A2AR antagonists:\nCPI-444 (396)\nZM241385 (38, 135, 402)\nKW6002 (402)\nSCH58261 (135, 388) ➣ Breast: E0771- HER2 (135)\n➣ Melanoma: B16-OVA (396)\n➣ Ovarian: ID8-OVA (388)\n➣ Fibrosarcoma:\nMCA205 (402)\n24JK-HER2 (135)\n➣ Sarcoma CMS4 (38) ➣ Primary tumor expansion rate ↓ (135, 396)\nPD-1 ICB (135)\nIFN-γ (135)\n➣ Metastasis formation ↓ (38, 402)\nNon-myeloablative pretreatment (402)\n➣ Survival ↑ (135, 388, 396, 402) PD-1 ICB (135) ↑ Adoptively transferred T cells (396)↑ Tbet, 41BB, CD69 in/on adoptively transferred CD8+ cells (396)↑ IFN-γ+ adoptively transferred T cells (135)↑ Stimulation-induced IFN-γ, TNF-α production by adoptively transferred CD8+ T cells (396)↑ Stimulation-induced IFN-γ production by adoptively transferred CD8+ or CD4+ T cells (402)↑ Tbet, 41BB in/on endogenous CD44+ CD8+ cells (396)↑ Stimulation-induced IL-2, IFN-γ, TNF-α production by endogenous CD8+CD44+ T cells (396)"}
2_test
{"project":"2_test","denotations":[{"id":"31244820-28165340-35366105","span":{"begin":50,"end":53},"obj":"28165340"},{"id":"31244820-20179192-35366106","span":{"begin":76,"end":79},"obj":"20179192"},{"id":"31244820-29923026-35366107","span":{"begin":81,"end":84},"obj":"29923026"},{"id":"31244820-29802128-35366108","span":{"begin":100,"end":103},"obj":"29802128"},{"id":"31244820-16916931-35366109","span":{"begin":123,"end":125},"obj":"16916931"},{"id":"31244820-16916931-35366110","span":{"begin":171,"end":173},"obj":"16916931"},{"id":"31244820-28165340-35366111","span":{"begin":175,"end":178},"obj":"28165340"},{"id":"31244820-29802128-35366112","span":{"begin":180,"end":183},"obj":"29802128"},{"id":"31244820-29802128-35366113","span":{"begin":193,"end":196},"obj":"29802128"},{"id":"31244820-28165340-35366114","span":{"begin":208,"end":211},"obj":"28165340"},{"id":"31244820-20179192-35366115","span":{"begin":213,"end":216},"obj":"20179192"},{"id":"31244820-28165340-35366116","span":{"begin":242,"end":245},"obj":"28165340"},{"id":"31244820-29923026-35366117","span":{"begin":268,"end":271},"obj":"29923026"},{"id":"31244820-20179192-35366118","span":{"begin":293,"end":296},"obj":"20179192"},{"id":"31244820-29802128-35366119","span":{"begin":322,"end":325},"obj":"29802128"},{"id":"31244820-28165340-35366120","span":{"begin":338,"end":341},"obj":"28165340"},{"id":"31244820-16916931-35366121","span":{"begin":359,"end":361},"obj":"16916931"},{"id":"31244820-28165340-35366122","span":{"begin":398,"end":401},"obj":"28165340"},{"id":"31244820-29923026-35366123","span":{"begin":403,"end":406},"obj":"29923026"},{"id":"31244820-28165340-35366124","span":{"begin":418,"end":421},"obj":"28165340"},{"id":"31244820-28165340-35366125","span":{"begin":430,"end":433},"obj":"28165340"},{"id":"31244820-16916931-35366126","span":{"begin":461,"end":463},"obj":"16916931"},{"id":"31244820-29802128-35366127","span":{"begin":465,"end":468},"obj":"29802128"},{"id":"31244820-29802128-35366128","span":{"begin":502,"end":505},"obj":"29802128"},{"id":"31244820-28165340-35366129","span":{"begin":521,"end":524},"obj":"28165340"},{"id":"31244820-20179192-35366130","span":{"begin":526,"end":529},"obj":"20179192"},{"id":"31244820-29923026-35366131","span":{"begin":531,"end":534},"obj":"29923026"},{"id":"31244820-29802128-35366132","span":{"begin":536,"end":539},"obj":"29802128"},{"id":"31244820-28165340-35366124","span":{"begin":418,"end":421},"obj":"28165340"},{"id":"31244820-29923026-35366133","span":{"begin":591,"end":594},"obj":"29923026"},{"id":"31244820-29923026-35366134","span":{"begin":655,"end":658},"obj":"29923026"},{"id":"31244820-28165340-35366135","span":{"begin":700,"end":703},"obj":"28165340"},{"id":"31244820-29923026-35366136","span":{"begin":790,"end":793},"obj":"29923026"},{"id":"31244820-29802128-35366137","span":{"begin":881,"end":884},"obj":"29802128"},{"id":"31244820-29923026-35366138","span":{"begin":933,"end":936},"obj":"29923026"},{"id":"31244820-29923026-35366139","span":{"begin":1022,"end":1025},"obj":"29923026"}],"text":"ACT \u0026 A2AR antagonism ➣ T cells:\nanti-HER2 CAR+ (135)\nOT-I (OVA-specific) (388, 396)\nTDLN-derived (402)\nReactive to CMS4 (38)\n➣ A2AR antagonists:\nCPI-444 (396)\nZM241385 (38, 135, 402)\nKW6002 (402)\nSCH58261 (135, 388) ➣ Breast: E0771- HER2 (135)\n➣ Melanoma: B16-OVA (396)\n➣ Ovarian: ID8-OVA (388)\n➣ Fibrosarcoma:\nMCA205 (402)\n24JK-HER2 (135)\n➣ Sarcoma CMS4 (38) ➣ Primary tumor expansion rate ↓ (135, 396)\nPD-1 ICB (135)\nIFN-γ (135)\n➣ Metastasis formation ↓ (38, 402)\nNon-myeloablative pretreatment (402)\n➣ Survival ↑ (135, 388, 396, 402) PD-1 ICB (135) ↑ Adoptively transferred T cells (396)↑ Tbet, 41BB, CD69 in/on adoptively transferred CD8+ cells (396)↑ IFN-γ+ adoptively transferred T cells (135)↑ Stimulation-induced IFN-γ, TNF-α production by adoptively transferred CD8+ T cells (396)↑ Stimulation-induced IFN-γ production by adoptively transferred CD8+ or CD4+ T cells (402)↑ Tbet, 41BB in/on endogenous CD44+ CD8+ cells (396)↑ Stimulation-induced IL-2, IFN-γ, TNF-α production by endogenous CD8+CD44+ T cells (396)"}