PMC:6562565 / 10143-11372 JSONTXT

{"project":"MyTest","denotations":[{"id":"31244820-29482842-35365327","span":{"begin":341,"end":343},"obj":"29482842"},{"id":"31244820-30012853-35365328","span":{"begin":345,"end":347},"obj":"30012853"},{"id":"31244820-29228209-35365329","span":{"begin":349,"end":351},"obj":"29228209"},{"id":"31244820-8923458-35365330","span":{"begin":436,"end":438},"obj":"8923458"},{"id":"31244820-25048519-35365331","span":{"begin":440,"end":442},"obj":"25048519"},{"id":"31244820-24009853-35365332","span":{"begin":544,"end":547},"obj":"24009853"},{"id":"31244820-21487525-35365333","span":{"begin":619,"end":621},"obj":"21487525"},{"id":"31244820-28006818-35365334","span":{"begin":707,"end":710},"obj":"28006818"},{"id":"31244820-8386657-35365335","span":{"begin":712,"end":715},"obj":"8386657"},{"id":"31244820-28324421-35365336","span":{"begin":781,"end":784},"obj":"28324421"},{"id":"31244820-26618165-35365336","span":{"begin":781,"end":784},"obj":"26618165"},{"id":"31244820-19750205-35365336","span":{"begin":781,"end":784},"obj":"19750205"},{"id":"31244820-11162617-35365337","span":{"begin":1064,"end":1067},"obj":"11162617"},{"id":"31244820-29928232-35365338","span":{"begin":1069,"end":1072},"obj":"29928232"},{"id":"31244820-15386342-35365339","span":{"begin":1100,"end":1103},"obj":"15386342"},{"id":"31244820-21343396-35365339","span":{"begin":1100,"end":1103},"obj":"21343396"},{"id":"31244820-20734919-35365339","span":{"begin":1100,"end":1103},"obj":"20734919"},{"id":"31244820-16330813-35365340","span":{"begin":1158,"end":1160},"obj":"16330813"},{"id":"31244820-19105964-35365341","span":{"begin":1162,"end":1164},"obj":"19105964"},{"id":"31244820-23819782-35365342","span":{"begin":1166,"end":1169},"obj":"23819782"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Although CD39 and CD73-mediated catabolism of extracellular ATP is considered to account for the bulk of intra-tumoral adenosine generation, expression levels of ecto-enzymes participating in alternative adenosine production pathways also rise in the advent of cancer. For instance, CD38 is frequently upregulated within neoplastic tissues (26, 96, 97) and sporadic evidence suggests that CD203a levels also increase on TME components (98, 99). Along the same lines, the serum concentration of PAP increases during prostate cancer progression (100) while others suggest it gets upregulated on cancerous tissue as well (28). Finally, several studies have demonstrated elevated levels of ALP on cancer cells (101, 102) as well as a correlation of serum ALP levels and disease stage (103–105). Critically, the relative contribution of these alternative adenosine-producing pathways toward intra-tumoral buildup of this nucleoside remains to be determined. Finally, along with aberrant production, defective uptake resulting from the down-modulation of equilibrative (106, 107) as well as concentrative (108–110) nucleoside transporters, also driven by hypoxia (34, 35, 111), further contributes to adenosine accumulation in the TME."}

{"project":"TEST0","denotations":[{"id":"31244820-72-78-3849475","span":{"begin":341,"end":343},"obj":"[\"29482842\"]"},{"id":"31244820-76-82-3849476","span":{"begin":345,"end":347},"obj":"[\"30012853\"]"},{"id":"31244820-80-86-3849477","span":{"begin":349,"end":351},"obj":"[\"29228209\"]"},{"id":"31244820-167-173-3849478","span":{"begin":436,"end":438},"obj":"[\"8923458\"]"},{"id":"31244820-171-177-3849479","span":{"begin":440,"end":442},"obj":"[\"25048519\"]"},{"id":"31244820-99-106-3849480","span":{"begin":544,"end":547},"obj":"[\"24009853\"]"},{"id":"31244820-174-180-3849481","span":{"begin":619,"end":621},"obj":"[\"21487525\"]"},{"id":"31244820-83-90-3849482","span":{"begin":707,"end":710},"obj":"[\"28006818\"]"},{"id":"31244820-88-95-3849483","span":{"begin":712,"end":715},"obj":"[\"8386657\"]"},{"id":"31244820-157-164-3849484","span":{"begin":781,"end":784},"obj":"[\"28324421\", \"26618165\", \"19750205\"]"},{"id":"31244820-111-118-3849485","span":{"begin":1064,"end":1067},"obj":"[\"11162617\"]"},{"id":"31244820-116-123-3849486","span":{"begin":1069,"end":1072},"obj":"[\"29928232\"]"},{"id":"31244820-147-154-3849487","span":{"begin":1100,"end":1103},"obj":"[\"15386342\", \"21343396\", \"20734919\"]"},{"id":"31244820-205-211-3849488","span":{"begin":1158,"end":1160},"obj":"[\"16330813\"]"},{"id":"31244820-209-215-3849489","span":{"begin":1162,"end":1164},"obj":"[\"19105964\"]"},{"id":"31244820-213-220-3849490","span":{"begin":1166,"end":1169},"obj":"[\"23819782\"]"}],"text":"Although CD39 and CD73-mediated catabolism of extracellular ATP is considered to account for the bulk of intra-tumoral adenosine generation, expression levels of ecto-enzymes participating in alternative adenosine production pathways also rise in the advent of cancer. For instance, CD38 is frequently upregulated within neoplastic tissues (26, 96, 97) and sporadic evidence suggests that CD203a levels also increase on TME components (98, 99). Along the same lines, the serum concentration of PAP increases during prostate cancer progression (100) while others suggest it gets upregulated on cancerous tissue as well (28). Finally, several studies have demonstrated elevated levels of ALP on cancer cells (101, 102) as well as a correlation of serum ALP levels and disease stage (103–105). Critically, the relative contribution of these alternative adenosine-producing pathways toward intra-tumoral buildup of this nucleoside remains to be determined. Finally, along with aberrant production, defective uptake resulting from the down-modulation of equilibrative (106, 107) as well as concentrative (108–110) nucleoside transporters, also driven by hypoxia (34, 35, 111), further contributes to adenosine accumulation in the TME."}

{"project":"2_test","denotations":[{"id":"31244820-29482842-35365327","span":{"begin":341,"end":343},"obj":"29482842"},{"id":"31244820-30012853-35365328","span":{"begin":345,"end":347},"obj":"30012853"},{"id":"31244820-29228209-35365329","span":{"begin":349,"end":351},"obj":"29228209"},{"id":"31244820-8923458-35365330","span":{"begin":436,"end":438},"obj":"8923458"},{"id":"31244820-25048519-35365331","span":{"begin":440,"end":442},"obj":"25048519"},{"id":"31244820-24009853-35365332","span":{"begin":544,"end":547},"obj":"24009853"},{"id":"31244820-21487525-35365333","span":{"begin":619,"end":621},"obj":"21487525"},{"id":"31244820-28006818-35365334","span":{"begin":707,"end":710},"obj":"28006818"},{"id":"31244820-8386657-35365335","span":{"begin":712,"end":715},"obj":"8386657"},{"id":"31244820-28324421-35365336","span":{"begin":781,"end":784},"obj":"28324421"},{"id":"31244820-26618165-35365336","span":{"begin":781,"end":784},"obj":"26618165"},{"id":"31244820-19750205-35365336","span":{"begin":781,"end":784},"obj":"19750205"},{"id":"31244820-11162617-35365337","span":{"begin":1064,"end":1067},"obj":"11162617"},{"id":"31244820-29928232-35365338","span":{"begin":1069,"end":1072},"obj":"29928232"},{"id":"31244820-15386342-35365339","span":{"begin":1100,"end":1103},"obj":"15386342"},{"id":"31244820-21343396-35365339","span":{"begin":1100,"end":1103},"obj":"21343396"},{"id":"31244820-20734919-35365339","span":{"begin":1100,"end":1103},"obj":"20734919"},{"id":"31244820-16330813-35365340","span":{"begin":1158,"end":1160},"obj":"16330813"},{"id":"31244820-19105964-35365341","span":{"begin":1162,"end":1164},"obj":"19105964"},{"id":"31244820-23819782-35365342","span":{"begin":1166,"end":1169},"obj":"23819782"}],"text":"Although CD39 and CD73-mediated catabolism of extracellular ATP is considered to account for the bulk of intra-tumoral adenosine generation, expression levels of ecto-enzymes participating in alternative adenosine production pathways also rise in the advent of cancer. For instance, CD38 is frequently upregulated within neoplastic tissues (26, 96, 97) and sporadic evidence suggests that CD203a levels also increase on TME components (98, 99). Along the same lines, the serum concentration of PAP increases during prostate cancer progression (100) while others suggest it gets upregulated on cancerous tissue as well (28). Finally, several studies have demonstrated elevated levels of ALP on cancer cells (101, 102) as well as a correlation of serum ALP levels and disease stage (103–105). Critically, the relative contribution of these alternative adenosine-producing pathways toward intra-tumoral buildup of this nucleoside remains to be determined. Finally, along with aberrant production, defective uptake resulting from the down-modulation of equilibrative (106, 107) as well as concentrative (108–110) nucleoside transporters, also driven by hypoxia (34, 35, 111), further contributes to adenosine accumulation in the TME."}