PMC:6537946 / 32224-33691 JSON TXT

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0_colil

{"project":"0_colil","denotations":[{"id":"31106338-30518863-6328","span":{"begin":594,"end":596},"obj":"30518863"},{"id":"31106338-30560955-6329","span":{"begin":782,"end":784},"obj":"30560955"}],"text":"Due to the scarcity of cardiac donors and the long waiting lists for heart transplants in many countries, the alternative of using xenografts has been explored for several years. The obviously most difficult limitation of using xenografts is the accelerated rate of rejection. Few, but very active, research groups focus on strategies to overcome the cross-species-derived rejection. Thus, genetically modified pig hearts were successfully transplanted into baboons using a modified preservation and immunosuppression protocol with an excellent 90-day survival rate with no signs of rejection [75]. This promising approach with xenotransplants must acquire further basic knowledge and long-term data before it can be tested further via large clinical examinations and human trials [76]. Comparing the major treatment options for end-stage heart failure from a future perspective, we believe that in the coming 10 years MCS will further improve and precise risk prediction can discriminate better candidates for heart transplants or MCS, hopefully. It is likely that treatment with an allograft heart transplant will be reserved for those patients who would profit the most from the donor heart in terms of the likelihood for long-term survival, such as young and otherwise healthy recipients. It is possible that a xenotransplant will be a clinical option in 10 years and that the indications for heart transplant and MCS might be discussed differently at that point."}

TEST0

{"project":"TEST0","denotations":[{"id":"31106338-210-216-6328","span":{"begin":594,"end":596},"obj":"[\"30518863\"]"},{"id":"31106338-183-189-6329","span":{"begin":782,"end":784},"obj":"[\"30560955\"]"}],"text":"Due to the scarcity of cardiac donors and the long waiting lists for heart transplants in many countries, the alternative of using xenografts has been explored for several years. The obviously most difficult limitation of using xenografts is the accelerated rate of rejection. Few, but very active, research groups focus on strategies to overcome the cross-species-derived rejection. Thus, genetically modified pig hearts were successfully transplanted into baboons using a modified preservation and immunosuppression protocol with an excellent 90-day survival rate with no signs of rejection [75]. This promising approach with xenotransplants must acquire further basic knowledge and long-term data before it can be tested further via large clinical examinations and human trials [76]. Comparing the major treatment options for end-stage heart failure from a future perspective, we believe that in the coming 10 years MCS will further improve and precise risk prediction can discriminate better candidates for heart transplants or MCS, hopefully. It is likely that treatment with an allograft heart transplant will be reserved for those patients who would profit the most from the donor heart in terms of the likelihood for long-term survival, such as young and otherwise healthy recipients. It is possible that a xenotransplant will be a clinical option in 10 years and that the indications for heart transplant and MCS might be discussed differently at that point."}

2_test

{"project":"2_test","denotations":[{"id":"31106338-30518863-28904641","span":{"begin":594,"end":596},"obj":"30518863"},{"id":"31106338-30560955-28904642","span":{"begin":782,"end":784},"obj":"30560955"}],"text":"Due to the scarcity of cardiac donors and the long waiting lists for heart transplants in many countries, the alternative of using xenografts has been explored for several years. The obviously most difficult limitation of using xenografts is the accelerated rate of rejection. Few, but very active, research groups focus on strategies to overcome the cross-species-derived rejection. Thus, genetically modified pig hearts were successfully transplanted into baboons using a modified preservation and immunosuppression protocol with an excellent 90-day survival rate with no signs of rejection [75]. This promising approach with xenotransplants must acquire further basic knowledge and long-term data before it can be tested further via large clinical examinations and human trials [76]. Comparing the major treatment options for end-stage heart failure from a future perspective, we believe that in the coming 10 years MCS will further improve and precise risk prediction can discriminate better candidates for heart transplants or MCS, hopefully. It is likely that treatment with an allograft heart transplant will be reserved for those patients who would profit the most from the donor heart in terms of the likelihood for long-term survival, such as young and otherwise healthy recipients. It is possible that a xenotransplant will be a clinical option in 10 years and that the indications for heart transplant and MCS might be discussed differently at that point."}

MyTest

{"project":"MyTest","denotations":[{"id":"31106338-30518863-28904641","span":{"begin":594,"end":596},"obj":"30518863"},{"id":"31106338-30560955-28904642","span":{"begin":782,"end":784},"obj":"30560955"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Due to the scarcity of cardiac donors and the long waiting lists for heart transplants in many countries, the alternative of using xenografts has been explored for several years. The obviously most difficult limitation of using xenografts is the accelerated rate of rejection. Few, but very active, research groups focus on strategies to overcome the cross-species-derived rejection. Thus, genetically modified pig hearts were successfully transplanted into baboons using a modified preservation and immunosuppression protocol with an excellent 90-day survival rate with no signs of rejection [75]. This promising approach with xenotransplants must acquire further basic knowledge and long-term data before it can be tested further via large clinical examinations and human trials [76]. Comparing the major treatment options for end-stage heart failure from a future perspective, we believe that in the coming 10 years MCS will further improve and precise risk prediction can discriminate better candidates for heart transplants or MCS, hopefully. It is likely that treatment with an allograft heart transplant will be reserved for those patients who would profit the most from the donor heart in terms of the likelihood for long-term survival, such as young and otherwise healthy recipients. It is possible that a xenotransplant will be a clinical option in 10 years and that the indications for heart transplant and MCS might be discussed differently at that point."}

testtesttest