PMC:6365940 / 3480-4546 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6365940","sourcedb":"PMC","sourceid":"6365940","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6365940","text":"Recently, some studies suggested that overactivation of Nrf2 signaling was one of the reasons for the drug resistance during chemotherapy [11], [12]. Frequent mutations of Keap1 in human cancers such as breast and lung cancer result in the upregulation of Nrf2 signaling [13]. We previously reported that Nrf2 and its downstream genes were highly expressed in MCF-7/DOX cells, and using Nrf2 siRNA to knockdown Nrf2 could reverse chemoresistance [14]. Similarly, tamoxifen and imatinib-resistant cancer cells also exhibited overactivation of Nrf2 signaling [15], [16]. Moreover, Hong et al. found that drug resistance was increased or decreased in pancreatic cancer cells with overexpression or knockdown of Nrf2, respectively [17]. Therefore, Nrf2 may be expected to become a pharmacological target to reverse chemoresistance in drug-resistant cancers with overactivation of Nrf2 signaling. It is necessary to find adjuvants that have inhibitory effect of Nrf2 activity and such adjuvants combined with chemotherapy drugs might be useful to reverse chemoresistance.","tracks":[{"project":"2_test","denotations":[{"id":"30735911-18413364-133473709","span":{"begin":139,"end":141},"obj":"18413364"},{"id":"30735911-24175806-133473710","span":{"begin":145,"end":147},"obj":"24175806"},{"id":"30735911-19321346-133473711","span":{"begin":272,"end":274},"obj":"19321346"},{"id":"30735911-22593043-133473712","span":{"begin":447,"end":449},"obj":"22593043"},{"id":"30735911-18539158-133473713","span":{"begin":558,"end":560},"obj":"18539158"},{"id":"30735911-15050748-133473714","span":{"begin":564,"end":566},"obj":"15050748"},{"id":"30735911-20118824-133473715","span":{"begin":728,"end":730},"obj":"20118824"}],"attributes":[{"subj":"30735911-18413364-133473709","pred":"source","obj":"2_test"},{"subj":"30735911-24175806-133473710","pred":"source","obj":"2_test"},{"subj":"30735911-19321346-133473711","pred":"source","obj":"2_test"},{"subj":"30735911-22593043-133473712","pred":"source","obj":"2_test"},{"subj":"30735911-18539158-133473713","pred":"source","obj":"2_test"},{"subj":"30735911-15050748-133473714","pred":"source","obj":"2_test"},{"subj":"30735911-20118824-133473715","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d1ec93","default":true}]}]}}