PMC:6365940 / 2569-3479 JSONTXT

{"project":"2_test","denotations":[{"id":"30735911-25458917-133473702","span":{"begin":172,"end":173},"obj":"25458917"},{"id":"30735911-15519281-133473703","span":{"begin":177,"end":178},"obj":"15519281"},{"id":"30735911-15110384-133473704","span":{"begin":440,"end":441},"obj":"15110384"},{"id":"30735911-14550278-133473705","span":{"begin":445,"end":446},"obj":"14550278"},{"id":"30735911-16426233-133473706","span":{"begin":450,"end":451},"obj":"16426233"},{"id":"30735911-19345732-133473707","span":{"begin":455,"end":456},"obj":"19345732"},{"id":"30735911-20446768-133473708","span":{"begin":651,"end":653},"obj":"20446768"}],"text":"Nrf2, a basic leucine zipper transcription factor, participates in protecting cells from electrophilic or oxidative stresses through regulating cellular redox homeostasis [4], [5]. Nrf2 regulates the expression of its downstream genes such as glutamate cysteine ligase (GCL), NADP(H): quinone oxidoreductase (NQO), heme oxygenase-1 (HO-1) and several ATP-dependent drug efflux pumps through binding to antioxidant-response elements (AREs) [6], [7], [8], [9]. Kelch-like ECH-associated protein 1 (Keap1), a substrate adaptor protein, connects Nrf2 and Cul3-dependent E3 ubiquitin ligase to form complex, suppresses Nrf2 activity under basal condition [10]. When the intracellular stable environment is changed, electrophiles and oxidants inhibit the Keap1-mediated proteasomal degradation, causing the translocation of Nrf2 to the nucleus. Then Nrf2 binds to AREs and enhances transcription of its target genes."}